Detailed information NTG0933123

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: V3435_RS07175
• Genome accession: NZ_CP144270
• Coordinates: 1451566..1452609 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain LA52
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1446566..1457609

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V3435_RS07145 (V3435_07140)	-	1446987..1448243 (-)	1257	WP_074347694.1	aminopeptidase	-
V3435_RS07150 (V3435_07145)	-	1448246..1448446 (-)	201	WP_000180460.1	DUF1128 family protein	-
V3435_RS07155 (V3435_07150)	-	1448593..1449057 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
V3435_RS07160 (V3435_07155)	-	1449064..1449339 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
V3435_RS07165 (V3435_07160)	-	1449617..1450834 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
V3435_RS07170 (V3435_07165)	vraR	1450947..1451576 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
V3435_RS07175 (V3435_07170)	vraS	1451566..1452609 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
V3435_RS07180 (V3435_07175)	liaF	1452606..1453307 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
V3435_RS07185 (V3435_07180)	-	1453322..1453708 (-)	387	WP_001110182.1	hypothetical protein	-
V3435_RS07190 (V3435_07185)	map	1453925..1454683 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
V3435_RS07195 (V3435_07190)	-	1455267..1456253 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
V3435_RS07200 (V3435_07195)	-	1456442..1456855 (-)	414	WP_025174370.1	hypothetical protein	-
V3435_RS07205 (V3435_07200)	-	1456884..1456994 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=933123 V3435_RS07175 WP_001017131.1 1451566..1452609(-) (vraS) [Staphylococcus aureus strain LA52]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=933123 V3435_RS07175 WP_001017131.1 1451566..1452609(-) (vraS) [Staphylococcus aureus strain LA52]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1