Detailed information NTG0931638

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: ACB339_RS01140
• Genome accession: NZ_CP167023
• Coordinates: 204364..205104 (+)
• Length: 246 a.a.
• NCBI ID: WP_080277139.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 3
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 199364..210104

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB339_RS01125 (ACB339_01125)	gltX	199898..201343 (+)	1446	WP_032463327.1	glutamate--tRNA ligase	-
ACB339_RS01130 (ACB339_01130)	-	201738..203084 (+)	1347	WP_002991186.1	sensor histidine kinase	-
ACB339_RS01135 (ACB339_01135)	-	203081..204360 (+)	1280	Protein_175	GHKL domain-containing protein	-
ACB339_RS01140 (ACB339_01140)	comE/blpR	204364..205104 (+)	741	WP_080277139.1	LytTR family DNA-binding domain-containing protein	Regulator
ACB339_RS01145 (ACB339_01145)	rnpA	205644..206003 (+)	360	WP_002992035.1	ribonuclease P protein component	-
ACB339_RS01150 (ACB339_01150)	-	205969..206796 (+)	828	WP_010921871.1	YidC/Oxa1 family membrane protein insertase	-
ACB339_RS01155 (ACB339_01155)	jag	206808..207722 (+)	915	WP_011054164.1	RNA-binding cell elongation regulator Jag/EloR	-
ACB339_RS01160 (ACB339_01160)	rpmH	208037..208171 (+)	135	WP_002885866.1	50S ribosomal protein L34	-
ACB339_RS01165 (ACB339_01165)	-	208445..209149 (+)	705	WP_002991176.1	N-acetylmannosamine-6-phosphate 2-epimerase	-

Sequence

Protein

• Length: 246 a.a.
• Molecular weight: 28909.53 Da
• Isoelectric Point: 6.4841

>NTDB_id=931638 ACB339_RS01140 WP_080277139.1 204364..205104(+) (comE/blpR) [Streptococcus pyogenes strain Isolate 3]
MMNIFILEDDFIQQTRIESIVVGILKETRIPCNQLEVFSTPQKLFESIQERGDHQLYFLDIEIGEYTRCGLELAAAIRQK
DPNAVIVFVTTHSEFAPISFKYKVSALDFIDKAGGQKQFKEQIEECIRYTYDMMSSRESKDMFLFETPQTRLKLPYKDIL
YFATATTPHKVCLWTQTERLEFYGNLSEIQAVAPKLFLCHRSYLVNLDKVVRIDKSKQLLYFENGDSCMVSRLKMKCLFE
RWEVLR

Nucleotide

• Length: 741 bp

>NTDB_id=931638 ACB339_RS01140 WP_080277139.1 204364..205104(+) (comE/blpR) [Streptococcus pyogenes strain Isolate 3]
ATGATGAACATTTTTATTCTTGAGGATGATTTTATCCAGCAGACACGCATAGAATCTATCGTAGTAGGCATCTTAAAAGA
GACTAGAATACCATGTAATCAGCTTGAAGTGTTCTCGACTCCTCAAAAATTATTTGAGAGTATCCAAGAAAGAGGAGACC
ATCAGCTGTATTTTTTAGATATTGAAATTGGTGAATATACTCGTTGTGGGCTTGAATTAGCTGCAGCTATTCGACAAAAA
GATCCTAATGCCGTTATTGTGTTTGTCACCACTCATTCAGAATTTGCTCCTATTTCTTTTAAATATAAGGTATCCGCTCT
AGATTTTATTGATAAAGCAGGTGGTCAAAAACAGTTTAAAGAACAAATCGAAGAATGTATCCGATATACTTACGATATGA
TGTCTAGTCGTGAGTCAAAGGACATGTTTTTATTTGAGACTCCACAGACAAGATTAAAATTGCCCTATAAGGATATTTTA
TACTTTGCTACAGCCACAACTCCTCACAAAGTTTGTTTATGGACTCAGACAGAAAGATTAGAGTTTTATGGTAATCTATC
TGAGATTCAAGCAGTAGCACCGAAACTTTTTTTGTGCCATAGATCCTACCTTGTGAATCTAGATAAGGTTGTTCGAATTG
ATAAGAGTAAGCAGCTCCTTTATTTCGAAAATGGTGATTCTTGTATGGTATCACGGTTAAAAATGAAATGTCTGTTTGAA
CGGTGGGAGGTCCTTCGCTAA

Domains

Predicted by InterProScan.

• LytTr DNA-binding domain (LytTR) (152-242)

• Response regulator receiver domain (Response_reg) (4-123)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	46.862	97.154	0.455
comE/comE1	Streptococcus equinus JB1	41.597	96.748	0.402
comE/comE2	Streptococcus equinus JB1	39.431	100	0.394
comE	Streptococcus pneumoniae Rx1	38.525	99.187	0.382
comE	Streptococcus pneumoniae D39	38.525	99.187	0.382
comE	Streptococcus pneumoniae R6	38.525	99.187	0.382
comE	Streptococcus pneumoniae TIGR4	38.525	99.187	0.382
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	38.115	99.187	0.378
comE/comE2	Streptococcus gordonii strain NCTC7865	38.115	99.187	0.378
comE	Streptococcus mitis NCTC 12261	37.759	97.967	0.37
comE	Streptococcus mitis SK321	37.759	97.967	0.37