Detailed information NTG0931497

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: ACB363_RS05945
• Genome accession: NZ_CP167021
• Coordinates: 1154610..1156709 (+)
• Length: 699 a.a.
• NCBI ID: WP_011528518.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 5
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1149610..1161709

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB363_RS05920 (ACB363_05920)	deoD	1149633..1150346 (-)	714	WP_011528521.1	purine-nucleoside phosphorylase	-
ACB363_RS05925 (ACB363_05925)	-	1151009..1151818 (-)	810	WP_011528520.1	purine-nucleoside phosphorylase	-
ACB363_RS05930 (ACB363_05930)	arsC	1151802..1152242 (-)	441	WP_002984932.1	arsenate reductase (glutaredoxin)	-
ACB363_RS05935 (ACB363_05935)	-	1152261..1153472 (-)	1212	WP_011528519.1	phosphopentomutase	-
ACB363_RS05940 (ACB363_05940)	rpiA	1153549..1154232 (-)	684	WP_009881270.1	ribose-5-phosphate isomerase RpiA	-
ACB363_RS05945 (ACB363_05945)	clpC	1154610..1156709 (+)	2100	WP_011528518.1	AAA family ATPase	Regulator
ACB363_RS05950 (ACB363_05950)	-	1156767..1157510 (-)	744	WP_011528517.1	hypothetical protein	-
ACB363_RS05955 (ACB363_05955)	yihA	1157658..1158257 (-)	600	WP_011184414.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
ACB363_RS05960 (ACB363_05960)	clpX	1158267..1159496 (-)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
ACB363_RS05965 (ACB363_05965)	-	1159816..1160313 (-)	498	WP_011528516.1	dihydrofolate reductase	-
ACB363_RS05970 (ACB363_05970)	-	1160393..1161232 (-)	840	WP_011017679.1	thymidylate synthase	-

Sequence

Protein

• Length: 699 a.a.
• Molecular weight: 77420.56 Da
• Isoelectric Point: 5.7992

>NTDB_id=931497 ACB363_RS05945 WP_011528518.1 1154610..1156709(+) (clpC) [Streptococcus pyogenes strain Isolate 5]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATNSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKERQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQTQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSGFNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNRAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILKEGQLVIRQNDQ

Nucleotide

• Length: 2100 bp

>NTDB_id=931497 ACB363_RS05945 WP_011528518.1 1154610..1156709(+) (clpC) [Streptococcus pyogenes strain Isolate 5]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAAATTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGATCCCGTCATCGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCTCTCGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGGCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAACCC
AAAATGTCACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCTGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTTGCAGCAGT
AGCACGCGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGGGTTTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCGCGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAAAAGAAGGACAACTAGTGA
TTAGGCAAAACGATCAGTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (443-600)

• ATPase family associated with various cellular activities (AAA) (AAA) (118-250)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (607-678)

• AAA lid domain (AAA_lid_9) (259-353)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	47.159	100	0.475
clpE	Streptococcus mutans UA159	49.302	92.275	0.455
clpE	Streptococcus pneumoniae TIGR4	50.08	89.413	0.448
clpE	Streptococcus pneumoniae Rx1	50.08	89.413	0.448
clpE	Streptococcus pneumoniae D39	50.08	89.413	0.448
clpE	Streptococcus pneumoniae R6	50.08	89.413	0.448
clpC	Bacillus subtilis subsp. subtilis str. 168	44.511	95.136	0.423
clpC	Streptococcus thermophilus LMD-9	43.103	91.273	0.393
clpC	Streptococcus thermophilus LMG 18311	42.947	91.273	0.392
clpC	Streptococcus pneumoniae Rx1	41.871	93.276	0.391
clpC	Streptococcus pneumoniae D39	41.871	93.276	0.391
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	41.348	93.419	0.386
clpC	Streptococcus pneumoniae TIGR4	42.857	90.129	0.386
clpC	Streptococcus mutans UA159	41.406	91.559	0.379