Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexA   Type   Machinery gene
Locus tag   ACB352_RS09420 Genome accession   NZ_CP167009
Coordinates   1853401..1855956 (-) Length   851 a.a.
NCBI ID   WP_011285287.1    Uniprot ID   Q48QT6
Organism   Streptococcus pyogenes strain Isolate 22     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1848401..1860956
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB352_RS09380 (ACB352_09380) - 1849386..1849640 (+) 255 WP_011285280.1 hypothetical protein -
  ACB352_RS09385 (ACB352_09385) - 1849637..1849810 (+) 174 WP_011285281.1 hypothetical protein -
  ACB352_RS09390 (ACB352_09390) - 1849816..1849989 (+) 174 WP_011285282.1 hypothetical protein -
  ACB352_RS09395 (ACB352_09395) - 1849991..1850500 (+) 510 WP_030126555.1 hypothetical protein -
  ACB352_RS09400 (ACB352_09400) - 1850574..1851062 (+) 489 WP_002992480.1 hypothetical protein -
  ACB352_RS09405 (ACB352_09405) - 1851466..1851828 (+) 363 WP_011285284.1 DUF1492 domain-containing protein -
  ACB352_RS09410 (ACB352_09410) - 1851803..1852186 (+) 384 WP_011285285.1 ArpU family phage packaging/lysis transcriptional regulator -
  ACB352_RS09415 (ACB352_09415) - 1852387..1853004 (+) 618 WP_021340716.1 hypothetical protein -
  ACB352_RS09420 (ACB352_09420) hexA 1853401..1855956 (-) 2556 WP_011285287.1 DNA mismatch repair protein MutS Machinery gene
  ACB352_RS09425 (ACB352_09425) - 1855943..1856149 (-) 207 WP_010922774.1 YlbF family regulator -
  ACB352_RS09430 (ACB352_09430) argR 1856292..1856729 (-) 438 WP_002982171.1 arginine repressor -
  ACB352_RS09435 (ACB352_09435) argS 1857020..1858711 (+) 1692 WP_011285288.1 arginine--tRNA ligase -
  ACB352_RS09440 (ACB352_09440) - 1858799..1859107 (+) 309 WP_002991370.1 bacteriocin immunity protein -
  ACB352_RS09445 (ACB352_09445) - 1859134..1860006 (-) 873 WP_002982164.1 YitT family protein -
  ACB352_RS09450 (ACB352_09450) - 1860049..1860927 (-) 879 WP_021340710.1 YitT family protein -

Sequence

Protein


Download         Length: 851 a.a.        Molecular weight: 95443.99 Da        Isoelectric Point: 4.9837

>NTDB_id=930489 ACB352_RS09420 WP_011285287.1 1853401..1855956(-) (hexA) [Streptococcus pyogenes strain Isolate 22]
MAKTNISPGMQQYLDIKKDYPDAFLLFRMGDFYELFYEDAVKAAQLLEIGLTSRNKNAENPIPMAGVPHHSAQQYIDVLI
ELGYKVAVAEQMEDPKQAVGVVKREVVQVITPGTVVDSAKPDSANNFLVAVDFDGCRYGLAYMDVSTGEFCVTDLADFTS
VRSEIQNLKAKEVLLGFDLSEEEQTILVKQMNLLLSYEETVYEDKSLIDGQLTTVELTAAGKLLQYVHKTQMRELSHLQA
LVHYEIKDYLQMSYATKSSLDLVENARTNKKHGSLYWLLDETKTAMGMRLLRSWIDRPLVSKEAILERQEIIQVFLNAFI
ERTDLSNSLKGVYDIERLSSRVSFGKANPKDLLQLGHTLAQVPYIKAILESFDSPCVDKLVNDIDSLPELEYLIRTAIDP
DAPATISEGSIIRTGFDERLDHYRKVMREGTGWIADIEAKERQASGINNLKIDYNKKDGYYFHVTNSNLSLVPEHFFRKA
TLKNSERYGTAELAKIEGQMLEAREESSSLEYDIFMCIRAQVETYINRLQKLAKILATVDVLQSLAVVAETNHYIRPQFN
DNHVITIQEGRHAVVEKVMGVQEYIPNSISFDQQTSIQLITGPNMSGKSTYMRQLALTVIMAQMGSFVAADHVDLPLFDA
IFTRIGAADDLISGQSTFMVEMMEANQAIKRASDNSLILFDELGRGTATYDGMALAQAIIEYIHDRVGAKTIFATHYHEL
TDLSTKLTSLVNVHVATLEKDGDVTFLHKIAEGPADKSYGIHVAKIAGLPKSLLKRADEVLTRLETQSRSTEIISVPSQV
ESSSAVRQGQLSLFGDEEKAHEIRQALEAIDVMNMTPLQAMTTLYELKKLL

Nucleotide


Download         Length: 2556 bp        

>NTDB_id=930489 ACB352_RS09420 WP_011285287.1 1853401..1855956(-) (hexA) [Streptococcus pyogenes strain Isolate 22]
ATGGCAAAAACTAACATTTCTCCTGGAATGCAACAGTATCTGGACATCAAAAAAGATTATCCAGATGCTTTTTTGCTTTT
TAGGATGGGTGACTTTTATGAATTATTTTACGAGGACGCTGTCAAAGCAGCACAACTCTTAGAAATTGGTTTGACCAGTC
GCAACAAGAATGCGGAAAATCCAATTCCTATGGCAGGCGTGCCACATCATTCTGCCCAACAATACATTGATGTGTTAATT
GAGTTGGGTTACAAGGTTGCTGTCGCAGAACAAATGGAAGACCCAAAGCAAGCTGTTGGGGTGGTGAAGCGTGAGGTCGT
TCAAGTCATAACTCCTGGAACGGTTGTGGATTCAGCTAAGCCAGATAGCGCCAATAACTTTTTGGTAGCTGTTGACTTTG
ATGGTTGCCGTTATGGATTGGCTTATATGGATGTGTCCACAGGTGAATTTTGCGTGACAGATTTGGCGGACTTTACGAGT
GTTCGTAGCGAAATCCAAAACCTCAAGGCAAAAGAAGTCTTACTAGGTTTTGATTTATCTGAAGAAGAACAGACGATTTT
GGTCAAGCAGATGAATTTGCTGCTTTCTTATGAAGAAACGGTCTATGAAGATAAATCTTTAATTGACGGCCAATTGACAA
CGGTAGAACTGACAGCGGCAGGAAAACTCTTGCAATACGTTCACAAAACACAAATGCGAGAACTCAGCCACTTGCAAGCA
TTGGTTCACTATGAGATCAAGGATTATTTGCAGATGTCGTATGCCACTAAGTCAAGTTTAGATTTGGTAGAAAATGCTAG
GACTAATAAAAAACATGGAAGTCTCTATTGGCTGTTAGATGAAACCAAGACAGCTATGGGGATGAGGCTTTTGCGCTCAT
GGATTGATCGACCTTTGGTTTCTAAAGAAGCTATTTTAGAGCGTCAAGAAATTATTCAAGTTTTTCTGAATGCTTTTATT
GAGCGAACCGATTTAAGCAATAGTTTAAAAGGTGTTTACGACATCGAACGCTTATCTAGTCGCGTGTCTTTTGGTAAGGC
AAATCCGAAAGATTTACTTCAATTGGGGCATACCTTAGCCCAAGTGCCTTATATCAAAGCTATCTTAGAGTCTTTTGACA
GTCCTTGTGTTGACAAACTTGTCAATGATATTGACAGTTTGCCTGAGTTGGAATACTTGATTAGAACAGCCATTGATCCA
GATGCACCAGCAACTATTAGTGAAGGCAGTATTATTCGTACTGGTTTTGATGAGCGCTTGGACCATTATCGTAAAGTGAT
GCGAGAAGGAACAGGTTGGATTGCGGATATTGAGGCTAAAGAGCGTCAAGCAAGCGGCATTAATAACCTAAAAATTGATT
ACAATAAAAAAGATGGTTATTATTTTCACGTTACGAATTCAAATCTTAGCTTAGTTCCCGAGCATTTTTTCAGAAAGGCA
ACTTTAAAAAATTCTGAGCGTTATGGAACAGCAGAATTGGCTAAGATTGAAGGTCAGATGTTAGAGGCTAGGGAAGAGTC
ATCTAGTTTAGAATACGATATTTTTATGTGTATTCGAGCTCAAGTTGAAACCTATATTAATCGTTTACAGAAACTGGCTA
AAATTTTGGCAACGGTAGATGTTTTGCAAAGTTTAGCAGTCGTTGCTGAAACCAATCATTATATCCGGCCGCAGTTCAAT
GATAATCATGTGATTACAATTCAAGAAGGTCGTCACGCGGTTGTTGAAAAGGTTATGGGAGTGCAGGAATACATTCCCAA
TAGTATCTCTTTTGACCAACAGACCAGTATTCAGCTGATTACAGGTCCAAATATGAGTGGTAAGTCGACTTATATGAGAC
AGCTGGCCTTAACGGTTATCATGGCCCAGATGGGTTCATTTGTGGCTGCTGACCATGTTGATTTACCTTTATTTGATGCG
ATTTTTACGCGTATTGGGGCTGCTGATGATTTGATTTCTGGGCAATCAACCTTTATGGTGGAGATGATGGAAGCAAACCA
AGCAATCAAACGCGCAAGTGACAACTCTCTTATTCTATTTGATGAACTGGGACGAGGTACGGCAACTTATGATGGTATGG
CTTTAGCCCAGGCAATTATTGAATATATCCATGATAGAGTTGGTGCTAAGACCATATTTGCAACGCATTATCATGAATTG
ACAGACTTGTCAACTAAGTTGACAAGTCTAGTCAATGTTCATGTAGCAACGCTTGAAAAAGATGGCGATGTTACCTTCCT
TCATAAGATTGCTGAGGGACCGGCGGATAAATCTTACGGTATTCATGTGGCAAAAATAGCAGGACTGCCAAAATCCCTAT
TAAAGAGAGCAGACGAAGTTCTGACCCGTTTAGAAACACAGTCACGATCTACTGAGATAATATCAGTCCCTTCACAAGTT
GAGTCAAGCAGCGCTGTTAGACAGGGGCAATTATCCCTTTTTGGTGATGAAGAGAAAGCTCATGAGATTAGGCAAGCACT
GGAAGCTATTGATGTCATGAACATGACCCCGCTTCAAGCAATGACAACCCTTTACGAATTGAAAAAGTTGTTATAG

Domains

Predicted by InterProScan.

MutS domain III (MutS_III)

(256-546)

MutS domain V (MutS_V)

(599-785)

MutS family domain IV (MutS_IV)

(415-506)

MutS domain I (MutS_I)

(8-118)

MutS domain II (MutS_II)

(126-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q48QT6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexA Streptococcus pneumoniae R6

71.563

100

0.716
  mutS Pseudomonas stutzeri strain ATCC 17587

37.383

100

0.376