Detailed information NTG0930461

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: ACB352_RS06365
• Genome accession: NZ_CP167009
• Coordinates: 1214396..1216495 (+)
• Length: 699 a.a.
• NCBI ID: WP_011284703.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Isolate 22
• Function: degradation of ComX (predicted from homology) Competence regulation

Genomic Context

Location: 1209396..1221495

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACB352_RS06340 (ACB352_06340)	deoD	1209500..1210213 (-)	714	WP_030126547.1	purine-nucleoside phosphorylase	-
ACB352_RS06345 (ACB352_06345)	-	1210798..1211607 (-)	810	WP_003053715.1	purine-nucleoside phosphorylase	-
ACB352_RS06350 (ACB352_06350)	arsC	1211591..1212031 (-)	441	WP_002984932.1	arsenate reductase (glutaredoxin)	-
ACB352_RS06355 (ACB352_06355)	-	1212047..1213258 (-)	1212	WP_011284705.1	phosphopentomutase	-
ACB352_RS06360 (ACB352_06360)	rpiA	1213335..1214018 (-)	684	WP_011284704.1	ribose-5-phosphate isomerase RpiA	-
ACB352_RS06365 (ACB352_06365)	clpC	1214396..1216495 (+)	2100	WP_011284703.1	AAA family ATPase	Regulator
ACB352_RS06370 (ACB352_06370)	-	1216548..1217297 (-)	750	WP_023612039.1	hypothetical protein	-
ACB352_RS06375 (ACB352_06375)	yihA	1217445..1218044 (-)	600	WP_011284702.1	ribosome biogenesis GTP-binding protein YihA/YsxC	-
ACB352_RS06380 (ACB352_06380)	clpX	1218054..1219283 (-)	1230	WP_002984948.1	ATP-dependent Clp protease ATP-binding subunit ClpX	Regulator
ACB352_RS06385 (ACB352_06385)	-	1219603..1220100 (-)	498	WP_159316964.1	dihydrofolate reductase	-
ACB352_RS06390 (ACB352_06390)	-	1220180..1221019 (-)	840	WP_011017679.1	thymidylate synthase	-

Sequence

Protein

• Length: 699 a.a.
• Molecular weight: 77389.50 Da
• Isoelectric Point: 5.6670

>NTDB_id=930461 ACB352_RS06365 WP_011284703.1 1214396..1216495(+) (clpC) [Streptococcus pyogenes strain Isolate 22]
MTHFSGKDPFVNMDDIFNQLMANMGGYRSENPRYLVNGREITPEEFQHYRQTGQLPVATTKATTSQMLTPKADSVLTQLG
TNLTQEARQGHLDPVIGRNKEIQDTAEILARRTKNNPVLVGDAGVGKTAVIEGLAQAIVNGDVPAAIKNKEIVSIDISSL
EAGTQYRGSFEETIQNLIQEVKEAGNIILFFDEIHQIVGAGATSSDSGSKGLADILKPALSRGELTLIGATTQDEYRNTI
LKNAALARRFNEVKVNAPSAEDTFHILMGIRNLYEQHHHITLPDNVLKAAVDYSIQYIPQRSLPDKAIDLLDMTAAHLAA
QHPVTDLKTLETEIAKQKERQEKAVAKEDFEKALAAKTRIETLQKQIEQHNQSQNVTATVNDIAESVERLTGIPVSNMGT
NDLERLKGISSRLKSHVIGQDEAVAAVARAIRRNRAGFDDGNRPIGSFLFVGPTGVGKTELAKQLALDLFGSKDAIIRLD
MSEYNDRTAVSKLIGTTAGYVGYDDNNNTLTERVRRNPYAIVLLDEIEKADPQIITLLLQVLDDGRLTDGQGNTINFKNT
VIIATSNAGFGQQDTETSGFNIMDRIAPYFRPEFLNRFNSIIKFNHLQKENLEEIVDLMLAEVNQTTAKKGISLTIADDA
KAHLIDLGYNHAMGARPLRRIIEQEIRDRITDYYLDHPEVKKLQAILEEGQLVIRQKDQ

Nucleotide

• Length: 2100 bp

>NTDB_id=930461 ACB352_RS06365 WP_011284703.1 1214396..1216495(+) (clpC) [Streptococcus pyogenes strain Isolate 22]
ATGACACATTTTTCTGGTAAAGATCCTTTTGTAAATATGGATGATATTTTCAACCAATTAATGGCAAACATGGGTGGTTA
TCGTAGCGAAAATCCCCGCTATCTCGTTAACGGTCGCGAAATAACTCCCGAAGAATTCCAACACTATCGTCAAACAGGAC
AACTCCCTGTAGCGACAACCAAAGCAACAACTTCTCAAATGTTAACACCTAAAGCTGATAGTGTATTGACTCAACTCGGA
ACTAACTTAACACAAGAAGCTCGTCAAGGGCATCTTGACCCCGTCATTGGTCGTAACAAAGAAATTCAAGATACCGCTGA
AATCTTGGCACGACGAACTAAAAATAATCCTGTCCTTGTCGGAGATGCTGGTGTCGGTAAAACTGCAGTCATTGAAGGTT
TAGCTCAAGCCATTGTTAATGGAGATGTCCCAGCTGCTATTAAAAACAAGGAAATCGTATCAATTGATATTTCTAGTCTT
GAAGCTGGTACACAGTATCGTGGTTCCTTTGAAGAGACCATTCAAAACTTGATTCAAGAAGTAAAAGAAGCTGGGAATAT
CATCTTATTTTTTGATGAAATTCATCAAATAGTTGGTGCTGGTGCCACAAGCAGTGATTCAGGCTCAAAGGGACTTGCAG
ATATTCTTAAACCAGCCTTGTCACGAGGAGAATTAACACTGATTGGTGCTACTACTCAAGACGAATACCGCAATACTATT
TTAAAAAATGCTGCACTCGCTCGTCGCTTTAATGAAGTTAAAGTGAATGCACCATCAGCTGAAGATACTTTTCACATTTT
AATGGGTATTCGTAATCTTTATGAACAACACCACCATATTACCCTTCCTGATAATGTTCTAAAAGCTGCTGTTGATTATT
CTATTCAATACATCCCACAGCGTAGCCTGCCAGATAAAGCAATTGACTTACTGGATATGACAGCTGCTCATTTAGCTGCG
CAACACCCGGTCACTGACTTAAAAACACTCGAAACTGAAATAGCTAAACAAAAAGAGAGGCAAGAAAAAGCTGTCGCCAA
AGAAGACTTTGAAAAAGCTTTAGCAGCAAAAACACGGATTGAAACATTACAAAAGCAAATTGAGCAACATAACCAAAGCC
AAAATGTTACTGCTACAGTCAATGATATCGCAGAGTCTGTAGAGCGCTTAACTGGTATTCCCGTCTCTAACATGGGGACT
AATGATTTAGAAAGGCTCAAAGGAATTAGCAGCCGCTTAAAAAGCCATGTCATCGGACAAGATGAGGCTGTTGCAGCAGT
AGCACGTGCTATTCGACGAAATCGAGCAGGTTTTGATGATGGTAACCGTCCAATAGGTTCTTTCCTTTTTGTGGGTCCAA
CTGGTGTTGGTAAAACAGAGTTAGCTAAACAATTAGCACTTGATTTATTTGGTTCCAAAGATGCTATTATTCGACTTGAT
ATGTCCGAATATAACGATCGCACTGCTGTGTCAAAATTGATTGGGACAACGGCTGGTTATGTTGGCTACGATGATAATAA
TAATACCCTAACTGAGCGTGTTCGTCGTAACCCTTATGCTATTGTCTTACTAGATGAAATTGAAAAAGCTGATCCTCAAA
TCATTACACTTCTTCTACAAGTGTTAGATGATGGACGATTGACAGATGGACAAGGAAATACTATTAACTTTAAAAATACC
GTTATTATTGCTACATCAAATGCCGGTTTTGGCCAACAAGATACGGAAACTTCTGGGTTTAACATTATGGATCGCATTGC
ACCTTATTTCAGACCAGAGTTTTTGAACCGTTTTAATAGTATCATTAAATTTAATCATCTGCAAAAAGAAAATTTAGAAG
AAATTGTTGATTTAATGCTAGCTGAAGTAAATCAAACCACCGCAAAAAAAGGTATTAGTTTAACGATTGCTGATGACGCT
AAAGCTCATTTGATAGATTTAGGGTACAATCACGCTATGGGAGCTCGTCCATTACGACGTATTATCGAACAGGAAATTCG
TGACCGTATAACTGATTATTATCTTGACCATCCAGAAGTCAAAAAACTTCAGGCAATCCTAGAAGAAGGACAACTAGTGA
TTAGGCAAAAAGATCAGTAA

Domains

Predicted by InterProScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (443-600)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (607-678)

• AAA lid domain (AAA_lid_9) (259-353)

• ATPase family associated with various cellular activities (AAA) (AAA) (118-250)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Lactococcus lactis subsp. cremoris KW2	47.443	100	0.478
clpE	Streptococcus mutans UA159	46.601	100	0.471
clpE	Streptococcus pneumoniae TIGR4	49.92	89.413	0.446
clpE	Streptococcus pneumoniae Rx1	49.92	89.413	0.446
clpE	Streptococcus pneumoniae D39	49.92	89.413	0.446
clpE	Streptococcus pneumoniae R6	49.92	89.413	0.446
clpC	Bacillus subtilis subsp. subtilis str. 168	44.662	95.136	0.425
clpC	Streptococcus thermophilus LMD-9	43.103	91.273	0.393
clpC	Streptococcus thermophilus LMG 18311	42.947	91.273	0.392
clpC	Streptococcus pneumoniae D39	41.871	93.276	0.391
clpC	Streptococcus pneumoniae Rx1	41.871	93.276	0.391
clpC	Streptococcus pneumoniae TIGR4	41.718	93.276	0.389
clpC	Streptococcus mutans UA159	41.406	91.559	0.379
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	42.173	89.557	0.378