Detailed information    

insolico Bioinformatically predicted

Overview

Name   uvrA   Type   Machinery gene
Locus tag   ACB348_RS02280 Genome accession   NZ_CP167002
Coordinates   395945..398773 (+) Length   942 a.a.
NCBI ID   WP_111704924.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Isolate 30     
Function   homologous recombination (predicted from homology)   
Homologous recombination

Genomic Context

Location: 390945..403773
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACB348_RS02235 (ACB348_02235) - 391192..392394 (+) 1203 WP_023611747.1 glucosaminidase domain-containing protein -
  ACB348_RS02240 (ACB348_02240) - 392581..392820 (-) 240 WP_003055855.1 hypothetical protein -
  ACB348_RS02245 (ACB348_02245) - 392889..393104 (-) 216 WP_023611751.1 hypothetical protein -
  ACB348_RS02250 (ACB348_02250) - 393106..393708 (-) 603 WP_023611748.1 AP endonuclease -
  ACB348_RS02255 (ACB348_02255) acrIIA3 393708..394082 (-) 375 WP_023611744.1 anti-CRISPR protein AcrIIA3 -
  ACB348_RS02260 (ACB348_02260) - 394215..394571 (-) 357 WP_003055891.1 hypothetical protein -
  ACB348_RS02265 (ACB348_02265) - 394573..395046 (-) 474 WP_076634523.1 hypothetical protein -
  ACB348_RS02270 (ACB348_02270) - 395086..395325 (-) 240 WP_136076189.1 hypothetical protein -
  ACB348_RS02275 (ACB348_02275) prx 395536..395718 (+) 183 WP_002986897.1 hypothetical protein Regulator
  ACB348_RS02280 (ACB348_02280) uvrA 395945..398773 (+) 2829 WP_111704924.1 excinuclease ABC subunit UvrA Machinery gene
  ACB348_RS02285 (ACB348_02285) - 398889..399962 (+) 1074 WP_111704925.1 Xaa-Pro peptidase family protein -
  ACB348_RS02290 (ACB348_02290) - 399997..400458 (+) 462 WP_002988493.1 deaminase -
  ACB348_RS02295 (ACB348_02295) efp 400554..401111 (+) 558 WP_002988496.1 elongation factor P -
  ACB348_RS02300 (ACB348_02300) - 401157..401546 (+) 390 WP_002983163.1 Asp23/Gls24 family envelope stress response protein -
  ACB348_RS02305 (ACB348_02305) nusB 401539..401991 (+) 453 WP_002988501.1 transcription antitermination factor NusB -
  ACB348_RS02310 (ACB348_02310) - 402132..403097 (-) 966 WP_014635676.1 LacI family DNA-binding transcriptional regulator -

Sequence

Protein


Download         Length: 942 a.a.        Molecular weight: 104064.23 Da        Isoelectric Point: 5.9996

>NTDB_id=929756 ACB348_RS02280 WP_111704924.1 395945..398773(+) (uvrA) [Streptococcus pyogenes strain Isolate 30]
MQDKLIIHGARAHNLKNIDVEIPRDKLVVVTGLSGSGKSSLAFDTIYAEGQRRYVESLSAYARQFLGNMEKPDVDSIDGL
SPAISIDQKTTSKNPRSTVGTVTEINDYLRLLYARVGTPYCINGHGAITASSVEQIVEQVLALPERTRMQILAPVVRRKK
GQHKTVFEKIQKDGYVRVRVDGDIFDVTEVPELSKSKMHNIEVVIDRLVNKDGIRSRLFDSIEAALRLGDGYVVIDTMDG
SELLFSEHYSCPVCGFTVPELEPRLFSFNAPFGSCPTCDGLGIKLEVDLDLVVPDPSKSLREGALAPWNPISSNYYPTML
EQAMASFGVDMDTPFEALTEEERDLVLYGSGDREFHFHYVNDFGGERNIDIPFEGVVTNVNRRYHETNSDYTRNVMRGYM
NELTCATCHGYRLNDQALCVHVGGEEGPHIGQISELSIADHLQLLEELELTENESTIAKPIVKEIHDRLTFLNNVGLNYL
ALSRAAGTLSGGESQRIRLATQIGSNLSGVLYILDEPSIGLHQRDNDRLIESLKKMRDLGNTLIVVEHDEDTMMQADWLI
DVGPGAGEFGGEIIASGTPKQVTKNKKSITGQYLSGKKFIPVPLERRSGNGRFIEIKGAAQNNLQSLDVRFPLGKFIAVT
GVSGSGKSTLVNSILKKAVAQKLNRNADKPGKYHSIFGIEHIERLIDIDQSPIGRTPRSNPATYTGVFDDIRDLFAQTNE
AKIRGYKKGRFSFNVKGGRCEACSGDGIIKIEMHFLPDVYVPCEVCHGRRYNSETLEVHYKEKNIAEVLDMTVDDALVFF
SAIPKIARKIQTIKDVGLGYVTLGQPATTLSGGEAQRMKLASELHKRSTGKSLYILDEPTTGLHTDDIARLLKVLERFVD
DGNTVLVIEHNLDVIKSADHIIDLGPEGGVGGGQIVATGTPEEVAQVKESYTGHYLKVKLQQ

Nucleotide


Download         Length: 2829 bp        

>NTDB_id=929756 ACB348_RS02280 WP_111704924.1 395945..398773(+) (uvrA) [Streptococcus pyogenes strain Isolate 30]
ATGCAAGATAAATTAATTATTCATGGGGCAAGAGCCCACAATTTAAAAAATATTGACGTGGAAATTCCACGAGACAAATT
AGTTGTCGTGACAGGGTTATCAGGTTCAGGAAAATCTAGTCTAGCCTTTGATACTATCTATGCGGAAGGACAACGTCGTT
ACGTAGAAAGTTTATCAGCTTACGCTAGGCAATTCCTGGGTAATATGGAAAAACCAGATGTGGATTCCATTGACGGTCTT
AGCCCTGCTATTTCCATTGACCAAAAAACCACCAGTAAGAACCCTCGCTCAACGGTTGGTACGGTGACTGAAATCAATGA
TTATTTACGTCTACTATATGCGCGTGTGGGCACACCTTACTGTATCAATGGGCATGGTGCTATCACGGCGTCTTCTGTGG
AGCAAATTGTTGAACAGGTCTTGGCCCTCCCTGAACGGACTCGAATGCAGATTTTAGCTCCTGTTGTTCGTCGGAAGAAG
GGGCAACACAAAACAGTTTTTGAGAAAATTCAAAAAGACGGCTATGTCCGTGTGCGCGTTGACGGGGATATTTTTGACGT
GACAGAAGTGCCAGAGTTGTCCAAAAGTAAGATGCACAACATTGAGGTGGTTATTGACCGTCTGGTTAATAAGGATGGTA
TTCGCAGTCGATTATTTGATTCCATTGAAGCAGCTTTAAGGCTGGGAGATGGTTATGTCGTCATTGATACTATGGATGGC
AGTGAATTGCTCTTTTCTGAGCATTATTCTTGTCCTGTCTGTGGATTTACGGTTCCTGAATTGGAGCCAAGACTCTTCTC
CTTTAATGCGCCGTTCGGTTCTTGTCCAACCTGTGATGGGCTGGGTATTAAGCTAGAAGTGGATTTGGACTTGGTTGTTC
CTGACCCAAGTAAGTCTTTGAGAGAGGGAGCTTTGGCGCCTTGGAATCCTATTTCCTCCAATTATTACCCAACCATGCTT
GAGCAAGCTATGGCAAGTTTTGGGGTGGATATGGATACACCTTTTGAGGCCTTGACTGAGGAAGAAAGAGATTTAGTGCT
TTATGGTTCAGGGGATAGAGAATTTCATTTTCACTATGTGAATGATTTTGGTGGTGAGCGTAACATTGACATTCCTTTTG
AAGGTGTTGTGACCAATGTTAATCGCCGTTACCACGAAACTAATAGTGATTATACGCGCAATGTGATGCGTGGTTATATG
AACGAATTGACCTGTGCTACTTGTCATGGTTACCGTTTGAATGACCAAGCCTTGTGTGTGCATGTGGGTGGCGAGGAAGG
ACCTCATATTGGTCAAATTTCAGAATTATCGATTGCCGACCACTTGCAGTTGTTGGAAGAATTAGAACTCACAGAAAATG
AAAGTACCATTGCTAAACCGATTGTCAAAGAAATCCATGACCGCCTGACCTTCTTAAATAATGTGGGACTGAATTATCTG
GCCTTGTCACGGGCTGCTGGGACTTTATCAGGTGGTGAAAGTCAACGAATCAGGTTAGCAACACAAATTGGTTCTAACCT
ATCAGGGGTGCTCTATATCTTGGATGAGCCTTCTATTGGATTGCATCAAAGAGACAATGACCGTTTGATCGAGAGCCTGA
AAAAAATGCGTGATTTGGGTAATACGTTAATTGTGGTAGAACACGATGAAGACACCATGATGCAGGCAGACTGGTTGATT
GATGTGGGGCCTGGGGCAGGTGAGTTCGGTGGAGAAATTATTGCCTCTGGAACGCCGAAACAAGTGACTAAGAATAAAAA
ATCCATCACGGGTCAATATTTGTCTGGTAAAAAATTCATTCCAGTGCCATTAGAGCGTCGTTCTGGTAATGGGCGATTCA
TTGAAATAAAAGGAGCAGCGCAGAATAATCTTCAAAGCCTCGACGTGAGATTCCCACTGGGTAAATTTATTGCGGTCACA
GGGGTATCAGGCTCAGGGAAATCAACCTTGGTTAATAGTATTTTGAAAAAGGCTGTCGCCCAAAAATTAAACCGTAATGC
TGATAAGCCTGGTAAATATCACTCTATTTTTGGTATTGAACATATTGAACGCTTGATTGACATTGACCAAAGTCCGATTG
GAAGGACGCCACGGTCAAATCCAGCCACCTATACGGGTGTCTTTGATGATATTCGAGACTTGTTTGCCCAAACCAACGAA
GCTAAGATTCGTGGCTACAAAAAAGGCCGTTTCTCTTTTAATGTCAAAGGTGGCCGTTGTGAGGCTTGTTCAGGTGATGG
GATTATCAAAATCGAAATGCACTTTTTGCCAGATGTTTATGTGCCTTGTGAGGTTTGCCACGGCAGACGGTATAATTCTG
AGACGCTTGAGGTGCATTATAAAGAAAAAAATATTGCTGAAGTGCTTGACATGACTGTCGATGATGCCTTGGTATTTTTC
TCTGCTATCCCTAAAATTGCCCGAAAAATTCAAACCATTAAGGATGTTGGTTTGGGTTATGTGACCTTAGGTCAACCAGC
TACCACCCTCTCTGGGGGAGAAGCTCAACGGATGAAGTTGGCTAGTGAATTGCACAAACGCTCGACAGGTAAGAGCTTGT
ATATCCTAGATGAGCCAACGACTGGTTTACACACAGATGATATTGCAAGGCTATTAAAAGTTTTGGAACGCTTTGTAGAC
GATGGTAATACGGTTCTTGTGATTGAGCATAATTTGGACGTTATCAAATCTGCTGACCATATTATTGACTTAGGACCAGA
AGGTGGTGTCGGAGGTGGTCAGATTGTTGCCACGGGGACACCAGAAGAGGTAGCTCAAGTTAAAGAAAGCTATACTGGTC
ATTATTTGAAAGTAAAACTACAACAATAG

Domains

Predicted by InterProScan.

UvrA interaction domain (UvrA_inter)

(132-238)

ABC transporter (ABC_tran)

(624-860)

UvrA DNA-binding domain (UvrA_DNA-bind)

(288-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  uvrA Streptococcus pneumoniae R6

85.35

100

0.854
  uvrA Streptococcus pneumoniae TIGR4

85.35

100

0.854
  uvrA Streptococcus pneumoniae D39

85.35

100

0.854