Detailed information NTG0925171

Bioinformatically predicted

Overview

• Name: clpE
• Type: Regulator
• Locus tag: VKP39_RS05740
• Genome accession: NZ_CP142353
• Coordinates: 1138508..1140790 (+)
• Length: 760 a.a.
• NCBI ID: WP_326623729.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain D641
• Function: repress competence development (at the early growth phase) (predicted from homology) Competence regulation

Genomic Context

Location: 1133508..1145790

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP39_RS05720 (VKP39_05720)	-	1134875..1136284 (-)	1410	WP_030126972.1	cryptochrome/photolyase family protein	-
VKP39_RS05725 (VKP39_05725)	-	1136433..1137167 (-)	735	WP_009880900.1	amino acid ABC transporter ATP-binding protein	-
VKP39_RS05730 (VKP39_05730)	-	1137167..1137853 (-)	687	WP_011054708.1	amino acid ABC transporter permease	-
VKP39_RS05735 (VKP39_05735)	-	1137980..1138210 (-)	231	WP_002983885.1	YkuJ family protein	-
VKP39_RS05740 (VKP39_05740)	clpE	1138508..1140790 (+)	2283	WP_326623729.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
VKP39_RS05745 (VKP39_05745)	-	1140918..1141373 (+)	456	WP_002993341.1	NUDIX hydrolase	-
VKP39_RS05750 (VKP39_05750)	-	1141424..1141726 (+)	303	WP_002983878.1	DUF1827 family protein	-
VKP39_RS05755 (VKP39_05755)	ileS	1141991..1144792 (-)	2802	WP_326623731.1	isoleucine--tRNA ligase	-

Sequence

Protein

• Length: 760 a.a.
• Molecular weight: 84692.85 Da
• Isoelectric Point: 4.9697

>NTDB_id=925171 VKP39_RS05740 WP_326623729.1 1138508..1140790(+) (clpE) [Streptococcus pyogenes strain D641]
MLCQNCNLNESTIHLYTSVNGKQRQVDLCQNCYQIMKSDPANSILNGLTPGYRAQDRSTSPFFDDFFGDLNNFRAFGNLP
NTPPTQAGQNGNGGGRYGGNYNGQRPAQPQTPNQQAKGLLEEFGINVTDIARNGNIDPVIGRDEEITRVIEILNRRTKNN
PVLIGEPGVGKTAVVEGLAQKIIDGTVPQKLQGKQVIRLDVVNLVQGTGIRGQFEERMQKLMEEIRNRKDVILFIDEIHE
IVGAGSAGDGNMDAGNILKPALACGELQLVGATTLNEYRIIEKDAALERRMQPVKVDEPSVEETITILKGIQPKYEDYHH
VKYSPAAIEAAAHLSNRYIQDRFLPDKAIDLLDEAGSKMNLTLNFVDPKEIDKRLIEAENLKAQATRDEDYERAAYFRDQ
ITKYKEMQAQKVDEQDIPIITEKTIEAIVEQKTNIPVGDLKEKEQSQLVNLANDLKAHVIGQDDAVDKIAKAIRRNRVGL
GTPNRPIGSFLFVGPTGVGKTELSKQLAIELFGSTNNMIRFDMSEYMEKHAVAKLVGAPPGYVGYEEAGQLTEQVRRNPY
SLILLDEVEKAHPDVMHMFLQVLDDGRLTDGQGRTVSFKDTIIIMTSNAGTGKSEASVGFGAAREGRTSSVLGELSNFFS
PEFMNRFDGIIEFKALSKEHLLHIVDLMLEDVNERLGYNGIHLDVTQKVKEKLVDLGYDPKMGARPLRRTIQDYIEDAIT
DYYLEHPTEKQLRALMTNSENITIKAVKEGDSFLNEESLD

Nucleotide

• Length: 2283 bp

>NTDB_id=925171 VKP39_RS05740 WP_326623729.1 1138508..1140790(+) (clpE) [Streptococcus pyogenes strain D641]
ATGCTGTGTCAAAATTGTAATTTAAACGAATCTACTATTCATCTTTATACAAGTGTTAATGGAAAACAAAGACAGGTTGA
TCTCTGTCAAAATTGTTATCAAATCATGAAATCCGATCCTGCCAATTCTATTTTAAATGGCCTAACCCCAGGATATAGAG
CACAAGATAGATCCACAAGTCCTTTCTTTGATGACTTTTTTGGTGATTTGAATAATTTTAGAGCTTTTGGTAATCTTCCA
AATACCCCACCTACTCAGGCAGGGCAAAATGGAAATGGCGGAGGACGCTATGGTGGTAACTACAACGGACAACGACCTGC
TCAGCCACAAACACCAAATCAGCAAGCAAAGGGCTTATTAGAAGAGTTTGGGATTAATGTCACAGATATTGCAAGAAATG
GTAATATTGATCCTGTTATTGGTCGTGACGAAGAGATTACACGCGTTATCGAGATCCTCAACCGCCGTACTAAAAATAAT
CCTGTGCTAATTGGTGAGCCTGGAGTTGGTAAAACTGCTGTTGTAGAAGGTTTGGCTCAAAAAATTATTGATGGTACTGT
TCCTCAAAAACTCCAAGGCAAGCAAGTGATTCGTCTTGATGTGGTTAACCTCGTTCAGGGAACAGGTATCCGTGGTCAGT
TTGAAGAGCGCATGCAAAAATTAATGGAAGAAATTCGCAATCGCAAGGATGTGATTCTCTTTATTGATGAAATTCATGAG
ATTGTCGGTGCTGGTTCTGCAGGAGACGGCAATATGGATGCTGGTAATATTTTAAAACCAGCCTTGGCCTGTGGTGAGTT
GCAACTCGTTGGTGCTACTACATTAAATGAATACCGTATTATTGAAAAAGACGCTGCCTTAGAACGACGTATGCAACCCG
TTAAAGTTGATGAACCTTCTGTTGAGGAAACCATCACGATTTTAAAAGGTATCCAACCGAAATACGAAGACTATCATCAT
GTCAAATATAGCCCAGCCGCTATTGAAGCTGCCGCTCATTTATCTAACCGCTATATTCAAGACCGTTTTCTTCCTGATAA
GGCTATTGATCTTCTGGACGAAGCTGGTTCCAAAATGAATCTAACCCTCAACTTTGTTGATCCTAAAGAAATTGACAAAC
GTCTTATTGAAGCTGAGAATCTCAAGGCGCAAGCTACTCGAGACGAAGACTATGAACGCGCAGCTTATTTCCGCGATCAA
ATTACAAAATACAAAGAAATGCAGGCTCAAAAAGTCGATGAGCAAGATATTCCCATCATTACTGAAAAAACCATTGAAGC
TATTGTAGAGCAAAAAACTAATATTCCAGTTGGGGACTTAAAAGAAAAGGAACAGTCTCAACTCGTAAACTTAGCCAATG
ATCTGAAAGCACACGTGATCGGGCAAGACGATGCTGTTGATAAAATCGCTAAGGCTATTCGTCGTAACCGTGTGGGATTA
GGAACTCCAAATCGCCCTATTGGTTCTTTCTTATTCGTTGGACCGACTGGGGTTGGTAAAACTGAATTGTCTAAACAACT
AGCCATTGAACTCTTTGGTTCGACAAACAATATGATTCGCTTTGACATGTCCGAATACATGGAAAAACACGCTGTCGCCA
AATTAGTCGGGGCTCCTCCAGGTTATGTCGGCTATGAAGAAGCTGGACAGCTAACCGAACAAGTTCGTCGCAATCCATAT
TCACTTATTCTCTTAGATGAGGTGGAAAAAGCCCATCCTGACGTCATGCACATGTTCTTACAAGTTCTTGATGATGGCCG
TTTAACAGATGGTCAAGGACGAACAGTCAGCTTCAAGGACACCATTATTATCATGACCTCTAATGCCGGAACAGGTAAAA
GCGAAGCTTCTGTCGGATTTGGTGCTGCTAGAGAAGGACGGACAAGTTCTGTCCTTGGTGAATTAAGCAACTTCTTCAGC
CCAGAGTTTATGAATCGTTTCGATGGTATTATTGAATTCAAAGCTTTATCTAAAGAGCATTTGCTGCATATCGTTGATTT
AATGCTGGAAGATGTTAATGAGCGCTTAGGCTATAATGGGATTCATCTTGATGTGACACAAAAGGTCAAAGAAAAATTAG
TAGATTTAGGCTATGATCCTAAAATGGGCGCTCGGCCGCTCCGTCGTACTATCCAAGATTATATAGAAGATGCCATTACA
GACTATTATTTAGAGCACCCAACTGAAAAACAGTTACGTGCACTGATGACAAACAGTGAAAATATCACGATTAAAGCTGT
TAAAGAGGGAGATTCTTTTCTTAACGAAGAGTCTCTCGATTAA

Domains

Predicted by InterproScan.

• AAA domain (Cdc48 subfamily) (AAA_2) (485-648)

• AAA lid domain (AAA_lid_9) (300-397)

• ATPase family associated with various cellular activities (AAA) (AAA) (162-264)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (656-729)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpE	Streptococcus mutans UA159	84.492	98.421	0.832
clpE	Streptococcus pneumoniae Rx1	82.423	98.816	0.814
clpE	Streptococcus pneumoniae D39	82.423	98.816	0.814
clpE	Streptococcus pneumoniae R6	82.423	98.816	0.814
clpE	Streptococcus pneumoniae TIGR4	82.29	98.816	0.813
clpC	Lactococcus lactis subsp. cremoris KW2	74.901	100	0.75
clpC	Bacillus subtilis subsp. subtilis str. 168	51.442	86.711	0.446
clpC	Streptococcus pneumoniae D39	47.84	82.237	0.393
clpC	Streptococcus pneumoniae Rx1	47.84	82.237	0.393
clpC	Streptococcus pneumoniae TIGR4	47.84	82.237	0.393
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	45.846	85.526	0.392
clpC	Streptococcus thermophilus LMD-9	46.795	82.105	0.384
clpC	Streptococcus mutans UA159	47.249	81.316	0.384
clpC	Streptococcus thermophilus LMG 18311	46.474	82.105	0.382