Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   VKP38_RS00340 Genome accession   NZ_CP142352
Coordinates   55507..56418 (+) Length   303 a.a.
NCBI ID   WP_023611326.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 2907-97     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 50507..61418
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP38_RS00325 (VKP38_00325) - 52349..53461 (+) 1113 WP_032464126.1 DUF262 domain-containing protein -
  VKP38_RS00330 (VKP38_00330) - 53465..54106 (+) 642 WP_063629364.1 hypothetical protein -
  VKP38_RS00335 (VKP38_00335) purB 54081..55373 (+) 1293 WP_032464128.1 adenylosuccinate lyase -
  VKP38_RS00340 (VKP38_00340) comR 55507..56418 (+) 912 WP_023611326.1 transcriptional regulator Rgg4/ComR Regulator
  VKP38_RS09220 comS 56502..56597 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  VKP38_RS00345 (VKP38_00345) ruvB 56644..57642 (+) 999 WP_063629365.1 Holliday junction branch migration DNA helicase RuvB -
  VKP38_RS00350 (VKP38_00350) - 57780..58217 (+) 438 WP_063629366.1 low molecular weight protein-tyrosine-phosphatase -
  VKP38_RS00355 (VKP38_00355) - 58240..58641 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  VKP38_RS00360 (VKP38_00360) - 58638..60413 (+) 1776 WP_021733211.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35685.21 Da        Isoelectric Point: 4.5164

>NTDB_id=925076 VKP38_RS00340 WP_023611326.1 55507..56418(+) (comR) [Streptococcus pyogenes strain 2907-97]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSGQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=925076 VKP38_RS00340 WP_023611326.1 55507..56418(+) (comR) [Streptococcus pyogenes strain 2907-97]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGGACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.472

99.34

0.581
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.37

96.37

0.495
  comR Streptococcus mutans UA159

46.358

99.67

0.462