Detailed information NTG0925006

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: VKP56_RS06215
• Genome accession: NZ_CP142350
• Coordinates: 1221123..1222160 (-)
• Length: 345 a.a.
• NCBI ID: WP_010922499.1
• Uniprot ID: A0A4U9I5V9
• Organism: Streptococcus pyogenes strain SS1445
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1216123..1227160

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP56_RS06190 (VKP56_06190)	-	1216127..1216654 (-)	528	WP_014635585.1	Dps family protein	-
VKP56_RS06195 (VKP56_06195)	-	1216882..1217508 (+)	627	WP_002989076.1	prepilin peptidase	-
VKP56_RS06200 (VKP56_06200)	rlmN	1217590..1218669 (-)	1080	WP_136267466.1	23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN	-
VKP56_RS06205 (VKP56_06205)	-	1218673..1219293 (-)	621	WP_326656713.1	YutD family protein	-
VKP56_RS06210 (VKP56_06210)	-	1219741..1220718 (-)	978	WP_002994809.1	LacI family DNA-binding transcriptional regulator	-
VKP56_RS06215 (VKP56_06215)	sepM	1221123..1222160 (-)	1038	WP_010922499.1	SepM family pheromone-processing serine protease	Regulator
VKP56_RS06220 (VKP56_06220)	coaD	1222147..1222638 (-)	492	WP_002983821.1	pantetheine-phosphate adenylyltransferase	-
VKP56_RS06225 (VKP56_06225)	rsmD	1222628..1223167 (-)	540	WP_002983819.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
VKP56_RS06230 (VKP56_06230)	asnA	1223290..1224282 (-)	993	WP_023611792.1	aspartate--ammonia ligase	-
VKP56_RS06235 (VKP56_06235)	arcC	1224595..1225545 (-)	951	WP_010922501.1	carbamate kinase	-
VKP56_RS06240 (VKP56_06240)	-	1225565..1226896 (-)	1332	WP_115224608.1	dipeptidase	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37541.24 Da
• Isoelectric Point: 9.6692

>NTDB_id=925006 VKP56_RS06215 WP_010922499.1 1221123..1222160(-) (sepM) [Streptococcus pyogenes strain SS1445]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide

• Length: 1038 bp

>NTDB_id=925006 VKP56_RS06215 WP_010922499.1 1221123..1222160(-) (sepM) [Streptococcus pyogenes strain SS1445]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCGCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGTTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCTAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (233-309)

• PDZ domain (PDZ_2) (129-192)

3D structure

• AlphaFold DB: A0A4U9I5V9

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	69.275	100	0.693