Detailed information    

insolico Bioinformatically predicted

Overview

Name   prx   Type   Regulator
Locus tag   VKP56_RS05730 Genome accession   NZ_CP142350
Coordinates   1143695..1143877 (-) Length   60 a.a.
NCBI ID   WP_011017964.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain SS1445     
Function   Inhibit ComR activation (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 1143695..1181208 1143695..1143877 within 0


Gene organization within MGE regions


Location: 1143695..1181208
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP56_RS05730 (VKP56_05730) prx 1143695..1143877 (-) 183 WP_011017964.1 hypothetical protein Regulator
  VKP56_RS05740 (VKP56_05740) - 1144223..1144798 (-) 576 WP_011054727.1 hypothetical protein -
  VKP56_RS05745 (VKP56_05745) spek 1145274..1146053 (-) 780 WP_038432391.1 streptococcal pyrogenic exotoxin SpeK -
  VKP56_RS05750 (VKP56_05750) - 1146357..1147223 (-) 867 WP_011054729.1 DUF334 domain-containing protein -
  VKP56_RS05755 (VKP56_05755) - 1147211..1147735 (-) 525 WP_011017840.1 Panacea domain-containing protein -
  VKP56_RS05760 (VKP56_05760) - 1147875..1149080 (-) 1206 WP_326656676.1 glucosaminidase domain-containing protein -
  VKP56_RS05765 (VKP56_05765) - 1149196..1149423 (-) 228 WP_000609113.1 phage holin -
  VKP56_RS05770 (VKP56_05770) - 1149420..1149692 (-) 273 WP_011017397.1 hypothetical protein -
  VKP56_RS05775 (VKP56_05775) - 1149704..1150315 (-) 612 WP_032464454.1 DUF1366 domain-containing protein -
  VKP56_RS05780 (VKP56_05780) - 1150318..1150749 (-) 432 WP_136107654.1 DUF1617 family protein -
  VKP56_RS05785 (VKP56_05785) - 1150758..1152539 (-) 1782 WP_136110606.1 gp58-like family protein -
  VKP56_RS05790 (VKP56_05790) - 1152554..1153663 (-) 1110 WP_159330039.1 hyaluronoglucosaminidase -
  VKP56_RS05795 (VKP56_05795) - 1153663..1155621 (-) 1959 WP_053308476.1 phage tail spike protein -
  VKP56_RS05800 (VKP56_05800) - 1155618..1156313 (-) 696 WP_010922452.1 hypothetical protein -
  VKP56_RS05805 (VKP56_05805) - 1156310..1158667 (-) 2358 WP_159330037.1 hypothetical protein -
  VKP56_RS05810 (VKP56_05810) - 1158667..1159038 (-) 372 WP_011054678.1 DUF5361 domain-containing protein -
  VKP56_RS05815 (VKP56_05815) - 1159053..1159316 (-) 264 WP_010922455.1 hypothetical protein -
  VKP56_RS05820 (VKP56_05820) - 1159327..1159917 (-) 591 WP_053308478.1 hypothetical protein -
  VKP56_RS05825 (VKP56_05825) - 1159933..1160268 (-) 336 WP_326656677.1 hypothetical protein -
  VKP56_RS05830 (VKP56_05830) - 1160269..1160505 (-) 237 WP_053308479.1 hypothetical protein -
  VKP56_RS05835 (VKP56_05835) - 1160498..1160836 (-) 339 WP_011054681.1 hypothetical protein -
  VKP56_RS05840 (VKP56_05840) - 1160796..1161218 (-) 423 WP_109828577.1 phage Gp19/Gp15/Gp42 family protein -
  VKP56_RS05845 (VKP56_05845) - 1161239..1161367 (-) 129 WP_258296905.1 hypothetical protein -
  VKP56_RS05850 (VKP56_05850) - 1161369..1162262 (-) 894 WP_053308481.1 phage major capsid protein -
  VKP56_RS05855 (VKP56_05855) - 1162266..1162730 (-) 465 WP_053308482.1 DUF4355 domain-containing protein -
  VKP56_RS05860 (VKP56_05860) - 1162811..1164226 (-) 1416 WP_011054685.1 terminase -
  VKP56_RS05865 (VKP56_05865) - 1164308..1164544 (-) 237 WP_011888764.1 hypothetical protein -
  VKP56_RS05870 (VKP56_05870) - 1164546..1164812 (-) 267 WP_002986828.1 hypothetical protein -
  VKP56_RS05875 (VKP56_05875) - 1164805..1164984 (-) 180 WP_032461150.1 hypothetical protein -
  VKP56_RS05880 (VKP56_05880) - 1165034..1165258 (-) 225 WP_002994100.1 hypothetical protein -
  VKP56_RS05885 (VKP56_05885) - 1165264..1166757 (-) 1494 WP_011017978.1 hypothetical protein -
  VKP56_RS05890 (VKP56_05890) - 1166750..1168018 (-) 1269 WP_011017979.1 phage portal protein -
  VKP56_RS05895 (VKP56_05895) - 1168015..1168371 (-) 357 WP_002994106.1 hypothetical protein -
  VKP56_RS05900 (VKP56_05900) - 1168520..1168864 (-) 345 WP_063629033.1 HNH endonuclease signature motif containing protein -
  VKP56_RS05905 (VKP56_05905) - 1168971..1169390 (-) 420 WP_010922470.1 DUF1492 domain-containing protein -
  VKP56_RS05910 (VKP56_05910) - 1169657..1170292 (-) 636 WP_010922070.1 N-6 DNA methylase -
  VKP56_RS05915 (VKP56_05915) - 1170294..1170578 (-) 285 WP_063629032.1 hypothetical protein -
  VKP56_RS05920 (VKP56_05920) - 1170565..1170768 (-) 204 WP_326656683.1 hypothetical protein -
  VKP56_RS05925 (VKP56_05925) - 1170755..1171267 (-) 513 WP_029714370.1 hypothetical protein -
  VKP56_RS05930 (VKP56_05930) - 1171264..1171605 (-) 342 WP_030127594.1 hypothetical protein -
  VKP56_RS05935 (VKP56_05935) - 1171782..1172579 (-) 798 WP_020837672.1 PD-(D/E)XK nuclease-like domain-containing protein -
  VKP56_RS05940 (VKP56_05940) - 1172572..1172772 (-) 201 WP_010922473.1 hypothetical protein -
  VKP56_RS05945 (VKP56_05945) - 1172769..1173758 (-) 990 WP_010922474.1 recombinase RecT -
  VKP56_RS05950 (VKP56_05950) - 1173758..1174090 (-) 333 WP_010922475.1 hypothetical protein -
  VKP56_RS05955 (VKP56_05955) - 1174146..1174352 (-) 207 WP_002988357.1 hypothetical protein -
  VKP56_RS05960 (VKP56_05960) - 1174361..1174501 (-) 141 WP_002988354.1 hypothetical protein -
  VKP56_RS05965 (VKP56_05965) - 1174498..1174731 (-) 234 WP_010922205.1 hypothetical protein -
  VKP56_RS05970 (VKP56_05970) - 1174712..1175098 (-) 387 WP_002990076.1 DnaD domain-containing protein -
  VKP56_RS05975 (VKP56_05975) - 1175224..1175493 (-) 270 WP_011106700.1 replication protein -
  VKP56_RS05980 (VKP56_05980) - 1175587..1175772 (-) 186 WP_010922477.1 hypothetical protein -
  VKP56_RS05985 (VKP56_05985) - 1175774..1176085 (-) 312 WP_010922478.1 excisionase -
  VKP56_RS05990 (VKP56_05990) - 1176355..1176567 (-) 213 WP_010922479.1 helix-turn-helix domain-containing protein -
  VKP56_RS05995 (VKP56_05995) - 1176769..1177524 (+) 756 WP_010922480.1 helix-turn-helix domain-containing protein -
  VKP56_RS06000 (VKP56_06000) - 1177536..1178054 (+) 519 WP_010922481.1 HIRAN domain-containing protein -
  VKP56_RS06005 (VKP56_06005) - 1178178..1179320 (+) 1143 WP_003051793.1 tyrosine-type recombinase/integrase -
  VKP56_RS06010 (VKP56_06010) - 1179409..1179684 (-) 276 WP_111713725.1 HU family DNA-binding protein -
  VKP56_RS06015 (VKP56_06015) - 1179783..1180370 (-) 588 WP_002989129.1 YpmS family protein -
  VKP56_RS06020 (VKP56_06020) - 1180348..1181190 (-) 843 WP_002992620.1 SGNH/GDSL hydrolase family protein -

Sequence

Protein


Download         Length: 60 a.a.        Molecular weight: 6841.79 Da        Isoelectric Point: 4.5183

>NTDB_id=925004 VKP56_RS05730 WP_011017964.1 1143695..1143877(-) (prx) [Streptococcus pyogenes strain SS1445]
MLTYDEFKQAIDNGYIAGDTVAIVRKDGQIFDYVLPHEKVKNGEVVTKEKVEEVLVELSR

Nucleotide


Download         Length: 183 bp        

>NTDB_id=925004 VKP56_RS05730 WP_011017964.1 1143695..1143877(-) (prx) [Streptococcus pyogenes strain SS1445]
ATGCTAACATACGACGAGTTTAAGCAAGCGATTGACAATGGATATATCGCAGGCGATACAGTAGCGATCGTGCGTAAAGA
CGGACAGATTTTTGATTATGTGTTGCCACATGAGAAAGTAAAGAATGGAGAAGTTGTGACTAAGGAAAAAGTGGAAGAGG
TGCTGGTGGAGCTTTCGAGATAA

Domains


No domain identified.



Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  prx Streptococcus pyogenes MGAS8232

100

100

1
  prx Streptococcus pyogenes MGAS315

85

100

0.85
  prx Streptococcus pyogenes MGAS315

80

100

0.8
  prx Streptococcus pyogenes MGAS315

73.333

100

0.733
  prx Streptococcus pyogenes MGAS315

90.244

68.333

0.617
  prx Streptococcus pyogenes MGAS315

83.721

71.667

0.6
  prx Streptococcus pyogenes MGAS315

78.571

70

0.55