Detailed information    

insolico Bioinformatically predicted

Overview

Name   comYA   Type   Machinery gene
Locus tag   VKP35_RS00775 Genome accession   NZ_CP142349
Coordinates   118913..119851 (+) Length   312 a.a.
NCBI ID   WP_009880361.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 11RS100     
Function   dsDNA binding to the cell surface; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 113913..124851
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP35_RS00765 (VKP35_00765) rpoC 114662..118303 (+) 3642 WP_111713111.1 DNA-directed RNA polymerase subunit beta' -
  VKP35_RS00770 (VKP35_00770) - 118455..118820 (+) 366 WP_002986560.1 DUF1033 family protein -
  VKP35_RS00775 (VKP35_00775) comYA 118913..119851 (+) 939 WP_009880361.1 competence type IV pilus ATPase ComGA Machinery gene
  VKP35_RS00780 (VKP35_00780) comYB 119787..120821 (+) 1035 WP_011054115.1 competence type IV pilus assembly protein ComGB Machinery gene
  VKP35_RS00785 (VKP35_00785) comYC 120823..121149 (+) 327 WP_111713112.1 competence type IV pilus major pilin ComGC Machinery gene
  VKP35_RS00790 (VKP35_00790) comGD 121124..121552 (+) 429 WP_002986548.1 competence type IV pilus minor pilin ComGD -
  VKP35_RS00795 (VKP35_00795) comGE 121509..121793 (+) 285 WP_002987779.1 competence type IV pilus minor pilin ComGE -
  VKP35_RS00800 (VKP35_00800) comYF 121786..122220 (+) 435 WP_002986542.1 competence type IV pilus minor pilin ComGF Machinery gene
  VKP35_RS00805 (VKP35_00805) comGG 122204..122530 (+) 327 WP_002986539.1 competence type IV pilus minor pilin ComGG -
  VKP35_RS00810 (VKP35_00810) comYH 122628..123581 (+) 954 WP_032467307.1 class I SAM-dependent methyltransferase Machinery gene
  VKP35_RS00815 (VKP35_00815) - 123640..124836 (+) 1197 WP_002986533.1 acetate kinase -

Sequence

Protein


Download         Length: 312 a.a.        Molecular weight: 35017.21 Da        Isoelectric Point: 8.2452

>NTDB_id=924917 VKP35_RS00775 WP_009880361.1 118913..119851(+) (comYA) [Streptococcus pyogenes strain 11RS100]
MVQALAKAILAKAEQVQAQDIYILPRADQYDLFLRIGDERRLVDVYQSDRMAPLVSHFKFVAGMIVGEKRRCQVGSCDYK
LSKDKQLSLRLSSVGDYRGQESLVIRLLHHQNKSVHYWFDGLTKVANQVGGRGLYLFAGPVGSGKTTLMYQLISNYHQEA
QVISIEDPVEIKNHQILQLQVNDDIGMTYDNLIKLSLRHQPDILVIGEIRDSQTARAVIRASLTGAMVFSTVHAKSISGV
YARLLELGVTKAELSNCLALIAYQRLLNGGALIDSTQNEFEYYSSSNWNQQIDQLLEAGHLNPKQAKLEKII

Nucleotide


Download         Length: 939 bp        

>NTDB_id=924917 VKP35_RS00775 WP_009880361.1 118913..119851(+) (comYA) [Streptococcus pyogenes strain 11RS100]
ATGGTACAAGCATTAGCAAAAGCTATTCTAGCAAAAGCTGAACAGGTTCAGGCACAAGATATTTATATTTTGCCAAGAGC
AGATCAATATGATCTTTTTTTACGAATAGGAGATGAAAGGAGATTAGTTGATGTTTATCAGAGCGATCGGATGGCTCCTC
TTGTTAGTCACTTTAAATTCGTTGCAGGAATGATAGTTGGTGAAAAGAGACGTTGTCAGGTGGGTTCATGTGATTATAAG
CTCAGTAAAGATAAGCAGTTATCTTTGCGCTTATCTAGCGTGGGTGATTATCGCGGGCAAGAAAGCTTAGTGATTCGTCT
GCTTCATCATCAAAATAAAAGTGTACATTATTGGTTTGATGGATTGACAAAAGTAGCCAATCAGGTTGGCGGTAGAGGGT
TGTATTTATTTGCAGGACCAGTTGGGTCTGGGAAGACAACCTTGATGTACCAGCTGATTTCGAATTATCATCAAGAAGCA
CAGGTTATTAGTATAGAAGATCCTGTAGAAATTAAAAATCACCAGATTTTACAATTACAAGTGAATGATGATATTGGTAT
GACTTATGACAATTTGATCAAACTGTCTTTACGCCATCAACCAGATATTTTAGTTATTGGTGAGATTCGAGATAGTCAAA
CAGCAAGAGCCGTTATTAGGGCTAGTCTAACAGGTGCCATGGTTTTTTCAACGGTTCACGCTAAAAGTATCTCGGGTGTT
TATGCAAGATTGTTAGAACTTGGTGTAACGAAAGCAGAACTGTCTAATTGCTTAGCATTAATTGCTTACCAAAGGTTACT
TAATGGAGGAGCATTGATTGACTCTACTCAAAACGAATTTGAATATTATTCCTCATCGAACTGGAATCAACAAATTGATC
AGCTTCTTGAGGCAGGACATCTCAATCCCAAGCAAGCTAAGCTTGAAAAAATTATCTAG

Domains

Predicted by InterproScan.

Type II/IV secretion system protein (T2SSE)

(9-267)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comYA Streptococcus mutans UA159

61.093

99.679

0.609
  comYA Streptococcus mutans UA140

61.093

99.679

0.609
  comYA Streptococcus gordonii str. Challis substr. CH1

60.129

99.679

0.599
  comGA/cglA Streptococcus sobrinus strain NIDR 6715-7

60

99.359

0.596
  comGA/cglA/cilD Streptococcus mitis NCTC 12261

58.842

99.679

0.587
  comGA/cglA/cilD Streptococcus pneumoniae Rx1

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae D39

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae R6

58.199

99.679

0.58
  comGA/cglA/cilD Streptococcus pneumoniae TIGR4

58.199

99.679

0.58
  comGA Lactococcus lactis subsp. cremoris KW2

50.161

99.679

0.5
  comGA Latilactobacillus sakei subsp. sakei 23K

39.31

92.949

0.365