Detailed information NTG0911637

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: U0320_RS07330
• Genome accession: NZ_CP139868
• Coordinates: 1450792..1451835 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain GP11
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1445792..1456835

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0320_RS07300 (U0320_07295)	-	1446214..1447470 (-)	1257	WP_001793428.1	aminopeptidase	-
U0320_RS07305 (U0320_07300)	-	1447473..1447673 (-)	201	WP_000180460.1	DUF1128 family protein	-
U0320_RS07310 (U0320_07305)	-	1447820..1448284 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
U0320_RS07315 (U0320_07310)	-	1448291..1448566 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
U0320_RS07320 (U0320_07315)	-	1448844..1450061 (+)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
U0320_RS07325 (U0320_07320)	vraR	1450173..1450802 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
U0320_RS07330 (U0320_07325)	vraS	1450792..1451835 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
U0320_RS07335 (U0320_07330)	liaF	1451832..1452533 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
U0320_RS07340 (U0320_07335)	-	1452548..1452934 (-)	387	WP_001110179.1	hypothetical protein	-
U0320_RS07345 (U0320_07340)	map	1453151..1453909 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
U0320_RS07350 (U0320_07345)	-	1454439..1455425 (+)	987	WP_000999716.1	FUSC family protein	-
U0320_RS07355 (U0320_07350)	-	1455856..1456269 (-)	414	WP_001670387.1	hypothetical protein	-
U0320_RS07360 (U0320_07355)	-	1456298..1456408 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=911637 U0320_RS07330 WP_001017131.1 1450792..1451835(-) (vraS) [Staphylococcus aureus strain GP11]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=911637 U0320_RS07330 WP_001017131.1 1450792..1451835(-) (vraS) [Staphylococcus aureus strain GP11]
ATGAACCATTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1