Detailed information NTG0911518

Bioinformatically predicted

Overview

• Name: stkP
• Type: Regulator
• Locus tag: U0449_RS07840
• Genome accession: NZ_CP139862
• Coordinates: 1515658..1517637 (+)
• Length: 659 a.a.
• NCBI ID: WP_000614538.1
• Uniprot ID: A0A0B7L145
• Organism: Streptococcus pneumoniae strain 05H0020-2
• Function: require for competence development; phosphorylate ComE (predicted from homology) Competence regulation

Genomic Context

Location: 1510658..1522637

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0449_RS07825	fmt	1512665..1513600 (+)	936	WP_000163693.1	methionyl-tRNA formyltransferase	-
U0449_RS07830	rsmB	1513593..1514906 (+)	1314	WP_050218979.1	16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB	-
U0449_RS07835	-	1514921..1515661 (+)	741	WP_000406247.1	Stp1/IreP family PP2C-type Ser/Thr phosphatase	-
U0449_RS07840	stkP	1515658..1517637 (+)	1980	WP_000614538.1	serine/threonine-protein kinase StkP	Regulator
U0449_RS07845	-	1517752..1518510 (+)	759	WP_000392880.1	threonine/serine exporter ThrE family protein	-
U0449_RS07850	-	1518512..1518961 (+)	450	WP_000176924.1	threonine/serine exporter family protein	-
U0449_RS07855	-	1519023..1519607 (+)	585	Protein_1504	transposase family protein	-
U0449_RS07860	-	1519581..1519775 (+)	195	WP_370657074.1	hypothetical protein	-
U0449_RS07865	-	1519906..1521078 (+)	1173	WP_000151962.1	hydroxymethylglutaryl-CoA synthase	-
U0449_RS07870	-	1521078..1522352 (+)	1275	WP_000704388.1	hydroxymethylglutaryl-CoA reductase, degradative	-

Sequence

Protein

• Length: 659 a.a.
• Molecular weight: 72288.81 Da
• Isoelectric Point: 9.0945

>NTDB_id=911518 U0449_RS07840 WP_000614538.1 1515658..1517637(+) (stkP) [Streptococcus pneumoniae strain 05H0020-2]
MIQIGKIFAGRYRIVKQIGRGGMADVYLAKDLILDGEEVAVKVLRTNYQTDPIAVARFQREARAMADLDHPHIVRITDIG
EEDGQQYLAMEYVAGLDLKRYIKEHYPLSNEEAVRIMGQILLAMRLAHTRGIVHRDLKPQNILLTPDGTAKVTDFGIAVA
FAETSLTQTNSMLGSVHYLSPEQARGSKATVQSDIYAMGIIFYEMLTGHIPYDGDSAVTIALQHFQKPLPSVIAENPSVP
QALENVIIKATAKKLTNRYRSVSEMYVDLSSSLSYNRRNESKLIFDETSKADTKTLPKVSQSTLTSIPKVQAQTEHKSIK
NPSQAVTEETYQPQAPKKHRFKMRYLILLASLVLVAASLIWILSRTPATIAIPDVAGQTVAEAKATLKKANFEIGEEKTE
ASEKVEEGRIIRTDPGAGTGRKEGTKINLVVSSGKQSFQISNYVGRKSSDVIAELKEKKVPDNLIKIEEEESNESEAGTV
LKQSLPEGTTYDLSKATQIVLTVAKKATTIQLGNYIGRNSTEVISELKQKKVPENLIKIEEEESSESEPGTIMKQSPGAG
TTYDVSKPTQIVLTVAKKVTSVAMPSYIGSSLEFTKNNLIQIVGIKEANIEVVEVTTAPAGSAEGMVVEQSPRAGEKVDL
NKTRVKISIYKPKTTSATP

Nucleotide

• Length: 1980 bp

>NTDB_id=911518 U0449_RS07840 WP_000614538.1 1515658..1517637(+) (stkP) [Streptococcus pneumoniae strain 05H0020-2]
ATGATCCAAATCGGCAAGATTTTTGCCGGACGCTATCGGATTGTCAAACAGATTGGTCGAGGAGGCATGGCGGATGTCTA
CCTAGCCAAAGACTTAATCTTAGATGGGGAAGAAGTGGCAGTGAAGGTTCTGAGGACCAACTACCAGACGGACCCGATAG
CTGTAGCTCGTTTTCAGCGTGAAGCGAGAGCTATGGCAGATCTAGACCATCCTCATATCGTTCGGATAACAGATATTGGC
GAGGAAGACGGTCAACAGTACCTAGCTATGGAGTATGTGGCTGGACTGGACCTCAAACGCTATATCAAGGAACATTATCC
TCTTTCTAATGAAGAAGCAGTCCGTATCATGGGACAAATTCTCTTGGCTATGCGCTTGGCCCATACTCGAGGAATTGTTC
ACAGGGACTTGAAACCTCAAAATATCCTTTTGACACCAGATGGGACTGCCAAGGTCACAGACTTTGGGATTGCTGTAGCC
TTTGCAGAGACAAGTCTGACCCAGACTAACTCGATGTTGGGCTCAGTTCATTACTTGTCACCAGAGCAGGCGCGTGGTTC
GAAGGCGACTGTGCAGAGTGATATCTATGCCATGGGGATTATTTTCTATGAGATGTTGACAGGCCATATCCCTTATGACG
GGGATAGCGCGGTGACCATTGCCCTCCAGCATTTCCAGAAACCCCTGCCGTCCGTTATTGCAGAAAATCCATCTGTACCT
CAGGCTTTAGAAAATGTTATTATCAAGGCAACTGCTAAAAAGTTGACCAATCGCTACCGCTCGGTTTCAGAGATGTATGT
GGACTTGTCTAGTAGCTTGTCCTACAATCGTAGAAATGAAAGTAAGTTAATCTTTGATGAAACGAGCAAGGCAGATACCA
AGACCTTGCCGAAGGTTTCTCAGAGTACCTTGACATCTATTCCTAAGGTTCAAGCGCAGACAGAACACAAATCAATCAAA
AACCCAAGTCAGGCTGTGACAGAGGAAACTTACCAACCACAAGCACCGAAAAAACATAGATTTAAGATGCGTTACCTGAT
TTTGTTGGCCAGCCTTGTATTGGTGGCAGCTTCTCTTATTTGGATACTATCCAGAACTCCTGCAACCATTGCCATTCCAG
ATGTGGCAGGTCAGACAGTTGCAGAGGCCAAGGCAACGCTCAAAAAAGCCAATTTTGAGATTGGTGAGGAGAAGACAGAG
GCTAGTGAAAAGGTGGAAGAAGGGCGGATTATCCGTACAGATCCTGGCGCTGGAACTGGTCGAAAAGAAGGAACGAAAAT
CAATTTGGTTGTCTCATCAGGCAAACAATCCTTCCAAATTAGTAATTATGTCGGCCGGAAATCTTCTGATGTTATCGCGG
AATTAAAAGAGAAAAAAGTTCCAGATAATTTGATTAAAATTGAGGAAGAAGAGTCGAATGAGAGTGAGGCTGGAACGGTC
TTGAAGCAAAGTCTACCAGAAGGTACGACCTATGACTTGAGCAAGGCAACTCAAATTGTTTTGACAGTAGCTAAAAAAGC
TACGACGATTCAATTAGGGAACTATATTGGACGGAACTCTACAGAAGTAATCTCAGAACTTAAGCAGAAGAAGGTTCCTG
AGAATTTGATTAAGATAGAGGAAGAAGAGTCCAGCGAAAGCGAACCAGGAACGATTATGAAACAAAGTCCAGGTGCCGGA
ACGACTTATGATGTGAGTAAACCTACTCAAATTGTCTTGACAGTAGCTAAAAAAGTTACAAGTGTTGCCATGCCGAGTTA
CATTGGTTCCAGCTTGGAGTTTACTAAGAACAATTTGATTCAAATTGTTGGGATTAAGGAAGCTAATATAGAAGTTGTAG
AAGTGACGACAGCGCCTGCAGGTAGTGCAGAAGGCATGGTTGTTGAACAAAGTCCTAGAGCAGGTGAAAAGGTAGACCTC
AATAAGACTAGAGTCAAGATTTCAATCTACAAACCTAAAACAACTTCAGCTACTCCTTAA

Domains

Predicted by InterproScan.

• Protein kinase domain (Pkinase) (12-227)

• PASTA domain (PASTA) (440-505)

• PASTA domain (PASTA) (582-651)

• PASTA domain (PASTA) (513-577)

• PASTA domain (PASTA) (371-432)

3D structure

• AlphaFold DB: A0A0B7L145

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
stkP	Streptococcus pneumoniae TIGR4	100	100	1
stkP	Streptococcus pneumoniae D39	99.545	100	0.995
stkP	Streptococcus pneumoniae R6	99.545	100	0.995
stkP	Streptococcus pneumoniae Rx1	99.393	100	0.994
pknB	Streptococcus mutans UA159	52.65	88.771	0.467
stkP/pknB	Streptococcus salivarius strain HSISS4	51.807	88.164	0.457