Detailed information NTG0090707

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: IDSSA_RS10565
• Genome accession: NZ_AP025249
• Coordinates: 2096727..2097770 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain IDSA1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2091727..2102770

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
IDSSA_RS10535 (IDSSA_0120440)	-	2092145..2093401 (-)	1257	WP_001795438.1	aminopeptidase	-
IDSSA_RS10540 (IDSSA_0120450)	-	2093404..2093604 (-)	201	WP_000180461.1	DUF1128 family protein	-
IDSSA_RS10545 (IDSSA_0120460)	-	2093751..2094215 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
IDSSA_RS10550 (IDSSA_0120470)	-	2094222..2094497 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
IDSSA_RS10555 (IDSSA_0120480)	-	2094775..2095992 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
IDSSA_RS10560 (IDSSA_0120490)	vraR	2096108..2096737 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
IDSSA_RS10565 (IDSSA_0120500)	vraS	2096727..2097770 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
IDSSA_RS10570 (IDSSA_0120510)	liaF	2097767..2098468 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
IDSSA_RS10575 (IDSSA_0120520)	-	2098483..2098869 (-)	387	WP_001110179.1	hypothetical protein	-
IDSSA_RS10580 (IDSSA_0120530)	map	2099086..2099844 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
IDSSA_RS10585 (IDSSA_0120540)	-	2100431..2101417 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
IDSSA_RS10590 (IDSSA_0120550)	-	2101848..2102261 (-)	414	WP_001549145.1	hypothetical protein	-
IDSSA_RS10595	-	2102290..2102400 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=90707 IDSSA_RS10565 WP_001017131.1 2096727..2097770(-) (vraS) [Staphylococcus aureus strain IDSA1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=90707 IDSSA_RS10565 WP_001017131.1 2096727..2097770(-) (vraS) [Staphylococcus aureus strain IDSA1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTTTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1