Detailed information NTG0905730

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SGQ79_RS10010
• Genome accession: NZ_CP138889
• Coordinates: 2012896..2013939 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 1221
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2007896..2018939

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGQ79_RS09980 (SGQ79_09975)	-	2008317..2009573 (-)	1257	WP_075583716.1	aminopeptidase	-
SGQ79_RS09985 (SGQ79_09980)	-	2009576..2009776 (-)	201	WP_000180460.1	DUF1128 family protein	-
SGQ79_RS09990 (SGQ79_09985)	-	2009923..2010387 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SGQ79_RS09995 (SGQ79_09990)	-	2010394..2010669 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SGQ79_RS10000 (SGQ79_09995)	-	2010947..2012164 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
SGQ79_RS10005 (SGQ79_10000)	vraR	2012277..2012906 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
SGQ79_RS10010 (SGQ79_10005)	vraS	2012896..2013939 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SGQ79_RS10015 (SGQ79_10010)	liaF	2013936..2014637 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SGQ79_RS10020 (SGQ79_10015)	-	2014652..2015038 (-)	387	WP_001110179.1	hypothetical protein	-
SGQ79_RS10025 (SGQ79_10020)	map	2015255..2016013 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SGQ79_RS10030 (SGQ79_10025)	-	2016484..2017470 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
SGQ79_RS10035 (SGQ79_10030)	-	2017901..2018314 (-)	414	WP_001670387.1	hypothetical protein	-
SGQ79_RS10040 (SGQ79_10035)	-	2018343..2018453 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=905730 SGQ79_RS10010 WP_001017131.1 2012896..2013939(-) (vraS) [Staphylococcus aureus strain 1221]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=905730 SGQ79_RS10010 WP_001017131.1 2012896..2013939(-) (vraS) [Staphylococcus aureus strain 1221]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1