Detailed information NTG0904195

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SGW62_RS00515
• Genome accession: NZ_CP138662
• Coordinates: 92471..93514 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain DA70520
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 87471..98514

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SGW62_RS00485	-	87900..88010 (+)	111	WP_001790257.1	hypothetical protein	-
SGW62_RS00490	-	88039..88452 (+)	414	WP_025173836.1	hypothetical protein	-
SGW62_RS00495	-	88883..89869 (-)	987	WP_000999714.1	aromatic acid exporter family protein	-
SGW62_RS00500	map	90397..91155 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SGW62_RS00505	-	91372..91758 (+)	387	WP_001110179.1	hypothetical protein	-
SGW62_RS00510	liaF	91773..92474 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
SGW62_RS00515	vraS	92471..93514 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SGW62_RS00520	vraR	93504..94133 (+)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SGW62_RS00525	-	94245..95462 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
SGW62_RS00530	-	95740..96015 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
SGW62_RS00535	-	96022..96486 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SGW62_RS00540	-	96633..96833 (+)	201	WP_000180460.1	DUF1128 family protein	-
SGW62_RS00545	-	96836..98092 (+)	1257	WP_001789555.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=904195 SGW62_RS00515 WP_001017131.1 92471..93514(+) (vraS) [Staphylococcus aureus strain DA70520]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=904195 SGW62_RS00515 WP_001017131.1 92471..93514(+) (vraS) [Staphylococcus aureus strain DA70520]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1