Detailed information NTG0090334

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: CC22TP_RS09470
• Genome accession: NZ_AP025177
• Coordinates: 1935296..1936339 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain TPS6281
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1930296..1941339

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
CC22TP_RS09440 (TPS6281TP_17740)	-	1930717..1931973 (-)	1257	WP_075583716.1	aminopeptidase	-
CC22TP_RS09445 (TPS6281TP_17750)	-	1931976..1932176 (-)	201	WP_000180460.1	DUF1128 family protein	-
CC22TP_RS09450 (TPS6281TP_17760)	-	1932323..1932787 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
CC22TP_RS09455 (TPS6281TP_17770)	-	1932794..1933069 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
CC22TP_RS09460 (TPS6281TP_17780)	-	1933347..1934564 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
CC22TP_RS09465 (TPS6281TP_17790)	vraR	1934677..1935306 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
CC22TP_RS09470 (TPS6281TP_17800)	vraS	1935296..1936339 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
CC22TP_RS09475 (TPS6281TP_17810)	liaF	1936336..1937037 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
CC22TP_RS09480 (TPS6281TP_17820)	-	1937052..1937438 (-)	387	WP_001110179.1	hypothetical protein	-
CC22TP_RS09485 (TPS6281TP_17830)	map	1937655..1938413 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
CC22TP_RS09490 (TPS6281TP_17840)	-	1938942..1939928 (+)	987	WP_000999713.1	FUSC family protein	-
CC22TP_RS09495 (TPS6281TP_17850)	-	1940359..1940772 (-)	414	WP_001670387.1	hypothetical protein	-
CC22TP_RS09500	-	1940801..1940911 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=90334 CC22TP_RS09470 WP_001017131.1 1935296..1936339(-) (vraS) [Staphylococcus aureus strain TPS6281]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=90334 CC22TP_RS09470 WP_001017131.1 1935296..1936339(-) (vraS) [Staphylococcus aureus strain TPS6281]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1