Detailed information NTG0902133

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: SE087_RS10115
• Genome accession: NZ_CP138360
• Coordinates: 2026859..2027902 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 17CS1042
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2021859..2032902

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SE087_RS10085 (SE087_10085)	-	2022280..2023536 (-)	1257	WP_233682404.1	aminopeptidase	-
SE087_RS10090 (SE087_10090)	-	2023539..2023739 (-)	201	WP_000180462.1	DUF1128 family protein	-
SE087_RS10095 (SE087_10095)	-	2023886..2024350 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
SE087_RS10100 (SE087_10100)	-	2024357..2024632 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
SE087_RS10105 (SE087_10105)	-	2024910..2026127 (+)	1218	WP_250737521.1	YihY/virulence factor BrkB family protein	-
SE087_RS10110 (SE087_10110)	vraR	2026240..2026869 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
SE087_RS10115 (SE087_10115)	vraS	2026859..2027902 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
SE087_RS10120 (SE087_10120)	liaF	2027899..2028600 (-)	702	WP_000149068.1	cell wall-active antibiotics response protein LiaF	-
SE087_RS10125 (SE087_10125)	-	2028615..2029001 (-)	387	WP_001110179.1	hypothetical protein	-
SE087_RS10130 (SE087_10130)	map	2029218..2029976 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
SE087_RS10135 (SE087_10135)	-	2030501..2031487 (+)	987	WP_000999713.1	FUSC family protein	-
SE087_RS10140 (SE087_10140)	-	2031676..2032089 (-)	414	WP_072491843.1	hypothetical protein	-
SE087_RS10145 (SE087_10145)	-	2032118..2032228 (-)	111	WP_042852778.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=902133 SE087_RS10115 WP_001017131.1 2026859..2027902(-) (vraS) [Staphylococcus aureus strain 17CS1042]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=902133 SE087_RS10115 WP_001017131.1 2026859..2027902(-) (vraS) [Staphylococcus aureus strain 17CS1042]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATTGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1