Detailed information    

insolico Bioinformatically predicted

Overview

Name   hexB   Type   Machinery gene
Locus tag   ABC804_RS09955 Genome accession   NZ_CP155536
Coordinates   1895483..1897432 (-) Length   649 a.a.
NCBI ID   WP_000018169.1    Uniprot ID   P0A3R1
Organism   Streptococcus pneumoniae strain M264-3     
Function   DNA mismatch repair (predicted from homology)   
Homologous recombination

Genomic Context

Location: 1890483..1902432
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ABC804_RS09930 (ABC804_09940) ruvA 1890747..1891340 (-) 594 WP_000271493.1 Holliday junction branch migration protein RuvA Machinery gene
  ABC804_RS09935 (ABC804_09945) ribD 1891745..1892845 (+) 1101 WP_001284092.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -
  ABC804_RS09940 (ABC804_09950) ribE 1892830..1893465 (+) 636 WP_000493846.1 riboflavin synthase -
  ABC804_RS09945 (ABC804_09955) - 1893485..1894690 (+) 1206 WP_000456639.1 bifunctional 3,4-dihydroxy-2-butanone-4-phosphate synthase/GTP cyclohydrolase II -
  ABC804_RS09950 (ABC804_09960) ribE 1894691..1895158 (+) 468 WP_001099502.1 6,7-dimethyl-8-ribityllumazine synthase -
  ABC804_RS09955 (ABC804_09965) hexB 1895483..1897432 (-) 1950 WP_000018169.1 DNA mismatch repair endonuclease MutL Machinery gene
  ABC804_RS09960 (ABC804_09970) - 1897788..1898228 (+) 441 WP_000861955.1 LytTR family DNA-binding domain-containing protein -
  ABC804_RS09965 (ABC804_09975) - 1898225..1898683 (+) 459 WP_000745054.1 DUF3021 domain-containing protein -
  ABC804_RS09970 (ABC804_09980) - 1898993..1900255 (+) 1263 WP_000075797.1 NRAMP family divalent metal transporter -
  ABC804_RS09975 (ABC804_09985) nrdI 1900548..1901018 (-) 471 WP_000849617.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -
  ABC804_RS09980 (ABC804_09990) - 1901096..1901629 (-) 534 WP_000729029.1 hypothetical protein -

Sequence

Protein


Download         Length: 649 a.a.        Molecular weight: 73434.89 Da        Isoelectric Point: 5.3001

>NTDB_id=897233 ABC804_RS09955 WP_000018169.1 1895483..1897432(-) (hexB) [Streptococcus pneumoniae strain M264-3]
MSHIIELPEMLANQIAAGEVIERPASVVKELVENAIDAGSSQIIIEIEEAGLKKVQITDNGHGIAHDEVELALRRHATSK
IKNQADLFRIRTLGFRGEALPSIASVSVLTLLTAVDGASHGTKLVARGGEVEEVIPATSPVGTKVCVEDLFFNTPARLKY
MKSQQAELSHIIDIVNRLGLAHPEISFSLISDGKEMTRTAGTGQLRQAIAGIYGLVSAKKMIEIENSDLDFEISGFVSLP
ELTRANRNYISLFINGRYIKNFLLNRAILDGFGSKLMVGRFPLAVIHIHIDPYLADVNVHPTKQEVRISKEKELMTLVSE
AIANSLKEQTLIPDALENLAKSTVRNREKVEQTILPLKENTLYYEKTEPSRPSQTEVADYQVELTDEGQDLTLFAKETLD
RLTKPAKLHFAERKPANYDQLDHPELDLASIDKAYDKLEREEASSFPELEFFGQMHGTYLFAQGRDGLYIIDQHAAQERV
KYEEYRESIGNVDQSQQQLLVPYIFEFPADDALRLKERMPLLEEVGVFLAEYGENQFILREHPIWMAEEEIESGIYEMCD
MLLLTKEVSIKKYRAELAIMMSCKRSIKANHRIDDHSARQLLYQLSQCDNPYNCPHGRPVLVHFTKSDMEKMFRRIQENH
TSLRELGKY

Nucleotide


Download         Length: 1950 bp        

>NTDB_id=897233 ABC804_RS09955 WP_000018169.1 1895483..1897432(-) (hexB) [Streptococcus pneumoniae strain M264-3]
ATGTCTCATATTATTGAATTGCCAGAGATGCTGGCAAACCAAATCGCGGCTGGAGAGGTCATTGAACGTCCTGCCAGTGT
GGTCAAAGAGTTGGTAGAAAATGCCATTGACGCGGGCTCTAGTCAGATTATCATTGAGATTGAGGAAGCTGGTCTCAAGA
AGGTTCAAATCACGGATAACGGTCATGGAATTGCCCACGATGAGGTGGAGTTGGCCCTGCGTCGCCATGCGACCAGTAAG
ATAAAAAATCAAGCAGATCTCTTTCGGATTCGGACGCTTGGTTTTCGTGGTGAAGCCTTGCCTTCTATTGCGTCTGTTAG
TGTCTTGACTCTGTTAACGGCGGTGGATGGTGCTAGTCATGGAACCAAGTTAGTCGCGCGCGGGGGTGAAGTTGAGGAAG
TCATCCCAGCGACTAGTCCTGTGGGAACCAAGGTTTGTGTGGAGGATCTCTTTTTCAACACGCCTGCCCGTCTCAAGTAT
ATGAAGAGCCAGCAAGCGGAGTTGTCTCATATCATTGATATTGTCAACCGTCTGGGCTTGGCCCATCCTGAGATTTCTTT
TAGCTTGATTAGTGATGGCAAGGAAATGACGCGGACAGCAGGGACTGGTCAATTGCGCCAAGCAATCGCAGGGATTTACG
GTTTGGTCAGTGCCAAGAAGATGATTGAAATTGAGAACTCTGACCTAGATTTCGAAATTTCAGGTTTTGTGTCCTTACCT
GAGTTGACTCGGGCTAACCGCAATTATATCAGCCTCTTCATCAATGGCCGTTATATCAAGAACTTCCTGCTCAATCGTGC
TATTTTGGATGGTTTTGGAAGCAAGCTTATGGTTGGACGTTTTCCACTGGCTGTCATTCACATCCATATCGACCCTTATC
TAGCGGATGTCAATGTGCATCCAACTAAGCAAGAGGTGCGGATTTCCAAGGAAAAAGAACTGATGACTCTGGTTTCAGAA
GCTATTGCAAATAGTCTCAAGGAACAAACCTTGATTCCAGATGCCTTGGAAAATCTTGCCAAATCGACCGTGCGCAATCG
TGAGAAGGTGGAGCAAACTATTCTCCCACTCAAAGAAAATACGCTCTACTATGAGAAAACTGAGCCGTCAAGACCTAGTC
AAACTGAAGTAGCTGATTATCAGGTAGAATTGACTGATGAAGGGCAGGATTTGACCCTGTTTGCCAAGGAAACCTTGGAC
CGATTGACCAAGCCAGCAAAACTGCATTTTGCAGAGAGAAAGCCTGCTAACTACGACCAGCTAGACCATCCAGAGTTAGA
TCTTGCTAGCATCGATAAGGCTTATGACAAACTGGAGCGAGAAGAAGCATCCAGCTTCCCAGAGTTGGAGTTTTTCGGAC
AAATGCACGGGACTTATCTCTTTGCCCAAGGGCGAGATGGACTTTACATCATAGATCAGCACGCTGCTCAGGAACGGGTC
AAGTACGAGGAGTACCGTGAAAGCATTGGCAATGTTGACCAGAGCCAGCAGCAACTCCTAGTGCCCTATATCTTTGAATT
TCCTGCGGATGATGCCCTGCGTCTCAAGGAAAGAATGCCTCTCTTAGAGGAAGTGGGCGTCTTTCTAGCAGAGTACGGAG
AAAATCAATTTATTCTACGTGAACATCCTATTTGGATGGCAGAAGAAGAGATTGAATCAGGCATCTATGAGATGTGCGAC
ATGCTCCTTTTGACCAAGGAAGTTTCTATCAAGAAATACCGAGCAGAGCTGGCTATCATGATGTCTTGCAAGCGATCTAT
CAAGGCCAATCATCGTATTGATGATCATTCAGCTAGACAACTCCTCTATCAGCTTTCTCAATGTGACAATCCCTATAACT
GTCCTCACGGACGTCCTGTTTTGGTGCATTTTACCAAGTCGGATATGGAAAAGATGTTCCGACGTATTCAGGAAAATCAC
ACCAGTCTCCGTGAGTTGGGGAAATATTAA

Domains

Predicted by InterProScan.

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c_3)

(25-107)

MutL C terminal dimerisation domain (MutL_C)

(450-592)

DNA mismatch repair protein, C-terminal domain (DNA_mis_repair)

(209-326)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB P0A3R1

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  hexB Streptococcus pneumoniae R6

100

100

1