Detailed information NTG0896096

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4707_RS04230
• Genome accession: NZ_CP137113
• Coordinates: 791623..792660 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain ZGX
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 786623..797660

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4707_RS04205	-	787362..788693 (-)	1332	WP_016398203.1	hemolysin family protein	-
R4707_RS04210	endA	788984..789808 (-)	825	WP_001036784.1	DNA-entry nuclease EndA	Machinery gene
R4707_RS04215	-	789847..790035 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
R4707_RS04220	murA	790028..791311 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4707_RS04225	-	791335..791565 (-)	231	WP_000250384.1	DUF1146 family protein	-
R4707_RS04230	sepM	791623..792660 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4707_RS04235	coaD	792644..793132 (-)	489	WP_001280753.1	pantetheine-phosphate adenylyltransferase	-
R4707_RS04240	rsmD	793122..793661 (-)	540	WP_001819515.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4707_RS04245	asnA	793726..794718 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4707_RS04250	-	794830..795513 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4707_RS04255	-	795569..796309 (-)	741	WP_000152678.1	RNA methyltransferase	-
R4707_RS04260	-	796343..796621 (+)	279	WP_081542916.1	acylphosphatase	-
R4707_RS04265	yidC	796699..797625 (+)	927	WP_081542918.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=896096 R4707_RS04230 WP_000727277.1 791623..792660(-) (sepM) [Streptococcus pneumoniae strain ZGX]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=896096 R4707_RS04230 WP_000727277.1 791623..792660(-) (sepM) [Streptococcus pneumoniae strain ZGX]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591