Detailed information    

insolico Bioinformatically predicted

Overview

Name   cclA/cilC   Type   Machinery gene
Locus tag   R4704_RS03235 Genome accession   NZ_CP137109
Coordinates   632512..633171 (+) Length   219 a.a.
NCBI ID   WP_000565011.1    Uniprot ID   A0A2R2HSW7
Organism   Streptococcus pneumoniae strain 11012     
Function   processing and translocation of ComGC; assembly of the pseudopilus (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 627512..638171
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4704_RS03195 mgaSpn 627582..629063 (-) 1482 WP_001205281.1 virulence factor transcriptional regulator MgaSpn -
  R4704_RS03200 - 629592..629756 (+) 165 WP_001809002.1 GlsB/YeaQ/YmgE family stress response membrane protein -
  R4704_RS03205 amaP 629840..630406 (+) 567 WP_000030213.1 alkaline shock response membrane anchor protein AmaP -
  R4704_RS03210 - 630418..630588 (+) 171 WP_000455066.1 DUF2273 domain-containing protein -
  R4704_RS03215 - 630627..631235 (+) 609 WP_000064115.1 Asp23/Gls24 family envelope stress response protein -
  R4704_RS03220 - 631266..631469 (+) 204 WP_000109957.1 CsbD family protein -
  R4704_RS03225 - 631579..631872 (-) 294 WP_306423777.1 transposase -
  R4704_RS03230 - 631996..632442 (-) 447 WP_166735727.1 GNAT family N-acetyltransferase -
  R4704_RS03235 cclA/cilC 632512..633171 (+) 660 WP_000565011.1 A24 family peptidase Machinery gene
  R4704_RS03240 trpA 633143..633919 (-) 777 WP_033707940.1 tryptophan synthase subunit alpha -
  R4704_RS03245 trpB 633912..635135 (-) 1224 WP_000331292.1 tryptophan synthase subunit beta -
  R4704_RS03250 - 635113..635712 (-) 600 WP_033707938.1 phosphoribosylanthranilate isomerase -
  R4704_RS03255 trpC 635699..636466 (-) 768 WP_000076548.1 indole-3-glycerol phosphate synthase TrpC -
  R4704_RS03260 trpD 636463..637467 (-) 1005 WP_000658684.1 anthranilate phosphoribosyltransferase -
  R4704_RS03265 - 637478..638044 (-) 567 WP_000601927.1 aminodeoxychorismate/anthranilate synthase component II -

Sequence

Protein


Download         Length: 219 a.a.        Molecular weight: 24890.04 Da        Isoelectric Point: 7.5762

>NTDB_id=895772 R4704_RS03235 WP_000565011.1 632512..633171(+) (cclA/cilC) [Streptococcus pneumoniae strain 11012]
MIDFYFFLVGSILASFLGLVIDRFPEQSIISSASHCDSCQTRLRPLDLIPILSQVFNRFCCRYCKVRYPVWYALFELGLG
LLFLLYSWELLSLSQVILITAGLTLGIYDFRHQEYPLLVWMTFHLILIASSGWNLVMVSFLILGILAHFIDIRMGAGDFL
FLASCALVFSVTELLILIQFASATGILAFLLQKKKERLPFVPFLLLATCLIIFGKLLLV

Nucleotide


Download         Length: 660 bp        

>NTDB_id=895772 R4704_RS03235 WP_000565011.1 632512..633171(+) (cclA/cilC) [Streptococcus pneumoniae strain 11012]
ATGATTGATTTTTATTTTTTTCTCGTCGGGAGCATTCTAGCTTCCTTTCTTGGTTTGGTCATTGACCGTTTTCCAGAGCA
ATCCATTATCAGTTCAGCCAGTCACTGCGATTCCTGTCAGACTCGCTTGCGTCCCTTAGATTTGATTCCGATTCTCTCAC
AGGTCTTCAATCGCTTCTGCTGTCGCTACTGCAAGGTCCGCTATCCTGTCTGGTATGCCCTCTTTGAACTAGGCTTAGGA
CTCCTCTTTCTGCTTTACTCTTGGGAATTACTTTCCTTGAGTCAAGTCATCCTAATCACTGCTGGTTTGACCTTGGGCAT
CTACGACTTTCGCCATCAGGAATATCCCTTACTGGTCTGGATGACTTTCCACCTAATCCTAATAGCTTCCTCTGGCTGGA
ATCTGGTCATGGTCTCCTTCCTCATACTTGGAATTTTGGCTCATTTTATCGATATCCGCATGGGTGCAGGGGATTTCCTT
TTTTTAGCTTCTTGCGCTCTCGTCTTTAGCGTAACGGAGTTACTGATCTTGATTCAGTTCGCTTCTGCGACGGGTATCCT
AGCCTTTCTCCTGCAAAAGAAAAAGGAAAGACTTCCTTTCGTGCCTTTCCTCTTACTTGCTACTTGTTTGATTATTTTTG
GTAAGCTACTGCTTGTCTGA

Domains

Predicted by InterproScan.

Bacterial Peptidase A24 N-terminal domain (A24_N_bact)

(8-89)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2R2HSW7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cclA/cilC Streptococcus pneumoniae Rx1

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae D39

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae R6

99.087

100

0.991
  cclA/cilC Streptococcus pneumoniae TIGR4

95.89

100

0.959
  cclA/cilC Streptococcus mitis SK321

92.694

100

0.927
  cclA/cilC Streptococcus mitis NCTC 12261

86.758

100

0.868