Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   R4711_RS05810 Genome accession   NZ_CP137107
Coordinates   1137525..1139957 (+) Length   810 a.a.
NCBI ID   WP_001109701.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 15H4024     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1132525..1144957
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4711_RS05780 cbpD 1132559..1133905 (+) 1347 WP_000698563.1 choline binding-anchored murein hydrolase CbpD -
  R4711_RS05785 - 1134161..1134451 (+) 291 WP_000647692.1 thiamine-binding protein -
  R4711_RS05790 - 1134414..1135172 (+) 759 WP_001813866.1 ABC transporter permease -
  R4711_RS05795 - 1135211..1136218 (+) 1008 WP_000754546.1 ABC transporter substrate-binding protein -
  R4711_RS05800 - 1136218..1136946 (+) 729 WP_000136224.1 ABC transporter ATP-binding protein -
  R4711_RS05805 - 1137065..1137523 (+) 459 WP_001211264.1 CtsR family transcriptional regulator -
  R4711_RS05810 clpC 1137525..1139957 (+) 2433 WP_001109701.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  R4711_RS05815 rr06 1140278..1140931 (+) 654 WP_001024075.1 two-component system response regulator RR06 -
  R4711_RS05820 hk06 1140928..1142268 (+) 1341 WP_000594659.1 two-component system sensor histidine kinase HK06 -
  R4711_RS05825 - 1142351..1142878 (+) 528 WP_000241929.1 isoprenylcysteine carboxyl methyltransferase family protein -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90179.92 Da        Isoelectric Point: 5.7851

>NTDB_id=895637 R4711_RS05810 WP_001109701.1 1137525..1139957(+) (clpC) [Streptococcus pneumoniae strain 15H4024]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SRRLQVLFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKAKYVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGSTLKIGV
KAGQLKFDIA

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=895637 R4711_RS05810 WP_001109701.1 1137525..1139957(+) (clpC) [Streptococcus pneumoniae strain 15H4024]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGACATTTTGGAGCTCGTTATCTAGA
GTCGTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTAGCAGGGGCAACTTTAAATGATTATCCGTATGAGA
TGGACCGTTTAGAAGAGGTGGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACCTTTACGGAATTGCCGTTC
TCCCGTCGTTTGCAGGTTCTTTTTGATGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTACTAGGGACAGAGCA
CGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCCCTTCGTCGAAATTTAGAAGAACGTGCAGGCTGGACTCGTGAAGATCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCCAATATGATGGGCATGCCGCAGACTCCTAGTGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATCGGTCGGGACAAGG
AAATCTCACGTATGATTCAAATCTTGAGCCGTAAGACTAAGAACAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA
ACAGCTCTGGCCCTTGGTCTTGCCCAGCGTATTGCTAGTGGTGACGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGA
ACTTGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAACGCATGAATAATATCATCAAGGATA
TTGAAGAAGATGGCCAAGTCATCCTCTTTATCGATGAACTCCACACCATCATGGGTTCTGGTAGCGGAATTGATTCGACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCCACCACTCAGGAAGAATA
TCAAAAACATATCGAAAAAGATGCGGCTCTTTCTCGTCGTTTCGCTAAAGTGACGATTGAAGAACCAAGTGTGGCAGATA
GTATGACTATTTTACAAGGTTTGAAGGCGACTTATGAGAAACATCACCGTGTACAAATCACAGATGAAGCGGTTGAAACA
GCGGTTAAGATGGCTCATCGTTATTTAACCAGTCGTCACTTGCCAGACTCTGCTATCGACCTCTTGGACGAAGCAGCAGC
AACAGTGCAAAATAAGGCAAAGTATGTAAAAGCAGACGATTCAGATTTGAGTCCAGCTGACAAGGCCCTGATGGATGGCA
AGTGGAAACAGGCAGCCCAGCTAATCGCAAAAGAAGAGGAAGTACCTGTCTACAAAGACTTGGTGACAGAGTCTGATATT
TTGACCACCTTGAGTCGCTTGTCAGGAATCCCAGTTCAAAAACTGACTCAGACTGACGCTAAGAAATATCTAAATCTTGA
AGCAGAACTCCATAAACGGGTTATCGGTCAAGATCAAGCTGTTTCAAGTATTAGTCGTGCGATTCGCCGTAATCAGTCAG
GAATTCGCAGTCACAAGCGTCCGATCGGTTCCTTTATGTTCCTAGGACCCACAGGTGTCGGTAAGACCGAGTTGGCCAAG
GCTTTGGCAGAAGTTCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTCGCAGC
CAGCCGTCTAAATGGAGCTCCTCCAGGCTATGTGGGTTACGAAGAAGGTGGGGAGTTGACAGAGAAGGTTCGCAATAAAC
CCTATTCCGTTCTCCTCTTTGATGAGGTAGAGAAGGCTCACCCAGATATCTTTAATGTTCTCTTGCAGGTTCTGGATGAC
GGTGTCTTGACAGATAGCAAGGGACGCAAGGTCGATTTTTCAAATACCATTATCATTATGACATCGAACCTAGGTGCGAC
TGCCCTTCGTGATGATAAGACTGTTGGTTTTGGGGCTAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAACTGAAAAAAGCTTATAGACCGGAATTCATCAACCGTATTGATGAGAAGGTGGTCTTCCATAGCCTATCTAGT
GACCATATGCAGGAAGTGGTGAAGATTATGGTCAAGCCTTTAGTGGCAAGTTTGGCTGAAAAAGGCATTGACTTGAAATT
ACAAGCTTCAGCTCTGAAATTGTTAGCAAATCAAGGATATGACCCAGAGATGGGAGCTCGCCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAGGACAAGTTGGCAGAACTTCTTCTCAAGGGAGATTTAGTGGCAGGCAGCACACTTAAGATTGGTGTC
AAAGCAGGCCAGTTAAAATTTGATATTGCATAA

Domains

Predicted by InterproScan.

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-139)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

AAA lid domain (AAA_lid_9)

(370-443)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae D39

99.63

100

0.996
  clpC Streptococcus pneumoniae TIGR4

99.63

100

0.996
  clpC Streptococcus pneumoniae Rx1

99.63

100

0.996
  clpC Streptococcus mutans UA159

66.913

100

0.672
  clpC Streptococcus thermophilus LMD-9

66.216

100

0.665
  clpC Streptococcus thermophilus LMG 18311

66.093

100

0.664
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.798

100

0.501
  clpC Bacillus subtilis subsp. subtilis str. 168

45.241

99.877

0.452
  clpE Streptococcus mutans UA159

49.355

76.543

0.378
  clpE Streptococcus pneumoniae Rx1

47.293

77.531

0.367
  clpE Streptococcus pneumoniae D39

47.293

77.531

0.367
  clpE Streptococcus pneumoniae R6

47.293

77.531

0.367
  clpE Streptococcus pneumoniae TIGR4

47.293

77.531

0.367
  clpC Lactococcus lactis subsp. cremoris KW2

46.955

77.037

0.362