Detailed information NTG0895574

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4702_RS06955
• Genome accession: NZ_CP137106
• Coordinates: 1356361..1357398 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 16P4028
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 1351361..1362398

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4702_RS06920	yidC	1351396..1352322 (-)	927	WP_317809550.1	membrane protein insertase YidC	-
R4702_RS06925	-	1352400..1352678 (-)	279	WP_001174613.1	acylphosphatase	-
R4702_RS06930	-	1352712..1353452 (+)	741	WP_000152674.1	RNA methyltransferase	-
R4702_RS06935	-	1353508..1354191 (+)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4702_RS06940	asnA	1354303..1355295 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4702_RS06945	rsmD	1355360..1355899 (+)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4702_RS06950	coaD	1355889..1356377 (+)	489	WP_044811672.1	pantetheine-phosphate adenylyltransferase	-
R4702_RS06955	sepM	1356361..1357398 (+)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4702_RS06960	-	1357456..1357686 (+)	231	WP_317809551.1	DUF1146 family protein	-
R4702_RS06965	murA	1357710..1358993 (+)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4702_RS06970	-	1358986..1359174 (+)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
R4702_RS06975	endA	1359213..1360037 (+)	825	WP_001036790.1	DNA-entry nuclease EndA	Machinery gene
R4702_RS06980	-	1360328..1361659 (+)	1332	WP_000390042.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=895574 R4702_RS06955 WP_000727277.1 1356361..1357398(+) (sepM) [Streptococcus pneumoniae strain 16P4028]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895574 R4702_RS06955 WP_000727277.1 1356361..1357398(+) (sepM) [Streptococcus pneumoniae strain 16P4028]
ATGAAAAAAAAGATTAGATGGCCCTTGTATGTCATTGCGGCCTTGATTGTGACCTTCTTGGCATTTGTGGTGCCTTTGCC
CTACTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591