Detailed information NTG0895523

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4699_RS10705
• Genome accession: NZ_CP137105
• Coordinates: 2112315..2113352 (+)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 16H2092
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 2107315..2118352

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4699_RS10670	yidC	2107350..2108276 (-)	927	WP_050104675.1	membrane protein insertase YidC	-
R4699_RS10675	-	2108354..2108632 (-)	279	WP_050104676.1	acylphosphatase	-
R4699_RS10680	-	2108666..2109406 (+)	741	WP_000152678.1	RNA methyltransferase	-
R4699_RS10685	-	2109462..2110145 (+)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4699_RS10690	asnA	2110257..2111249 (+)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4699_RS10695	rsmD	2111314..2111853 (+)	540	WP_050104677.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4699_RS10700	coaD	2111843..2112331 (+)	489	WP_050104678.1	pantetheine-phosphate adenylyltransferase	-
R4699_RS10705	sepM	2112315..2113352 (+)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4699_RS10710	-	2113410..2113640 (+)	231	WP_001809307.1	DUF1146 family protein	-
R4699_RS10715	murA	2113664..2114947 (+)	1284	WP_000358035.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4699_RS10720	-	2114940..2115128 (+)	189	WP_001813390.1	DNA-directed RNA polymerase subunit beta	-
R4699_RS10725	endA	2115167..2115991 (+)	825	WP_001036786.1	DNA-entry nuclease EndA	Machinery gene
R4699_RS10730	-	2116282..2117613 (+)	1332	WP_000390043.1	hemolysin family protein	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=895523 R4699_RS10705 WP_000727277.1 2112315..2113352(+) (sepM) [Streptococcus pneumoniae strain 16H2092]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895523 R4699_RS10705 WP_000727277.1 2112315..2113352(+) (sepM) [Streptococcus pneumoniae strain 16H2092]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCTACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACGGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGACTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGAAAAAATGGGATTGGAATCGGCTTGATTGATCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGCCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591