Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpC   Type   Regulator
Locus tag   R4709_RS05675 Genome accession   NZ_CP137102
Coordinates   1097537..1099969 (+) Length   810 a.a.
NCBI ID   WP_127245097.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16H3071-2     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1092537..1104969
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4709_RS05645 cbpD 1092570..1093916 (+) 1347 WP_000698571.1 choline binding-anchored murein hydrolase CbpD -
  R4709_RS05650 - 1094174..1094464 (+) 291 WP_000647661.1 thiamine-binding protein -
  R4709_RS05655 - 1094427..1095185 (+) 759 WP_001245130.1 ABC transporter permease -
  R4709_RS05660 - 1095223..1096230 (+) 1008 WP_054365717.1 ABC transporter substrate-binding protein -
  R4709_RS05665 - 1096230..1096958 (+) 729 WP_000136224.1 ABC transporter ATP-binding protein -
  R4709_RS05670 - 1097077..1097535 (+) 459 WP_001211274.1 CtsR family transcriptional regulator -
  R4709_RS05675 clpC 1097537..1099969 (+) 2433 WP_127245097.1 ATP-dependent Clp protease ATP-binding subunit Regulator
  R4709_RS05680 rr06 1100611..1101264 (+) 654 WP_001024077.1 two-component system response regulator RR06 -
  R4709_RS05685 hk06 1101261..1102592 (+) 1332 WP_277779618.1 two-component system sensor histidine kinase HK06 -
  R4709_RS05690 - 1102675..1103202 (+) 528 WP_000241935.1 isoprenylcysteine carboxyl methyltransferase family protein -

Sequence

Protein


Download         Length: 810 a.a.        Molecular weight: 90210.94 Da        Isoelectric Point: 5.8612

>NTDB_id=895254 R4709_RS05675 WP_127245097.1 1097537..1099969(+) (clpC) [Streptococcus pneumoniae strain 16H3071-2]
MNYSKALNECIESAYMVAGHFGARYLESWHLLIAMSNHSYSVAGATLNDYPYEMDRLEEVALELTETDYSQDETFTELPF
SRRLQILFDEAEYVASVVHAKVLGTEHVLYAILHDGNALATRILERAGFSYEDKKDQVKIAALRRNLEERAGWTREDLKA
LRQRHRTVADKQNSMANMMGMPQTPSGGLEDYTHDLTEQARSGKLEPVIGRDKEISRMIQILSRKTKNNPVLVGDAGVGK
TALALGLAQRIASGDVPAEMAKMRVLELDLMNVVAGTRFRGDFEERMNNIIKDIEEDGQVILFIDELHTIMGSGSGIDST
LDAANILKPALARGTLRTVGATTQEEYQKHIEKDAALSRRFAKVTIEEPSVADSMTILQGLKATYEKHHRVQITDEAVET
AVKMAHRYLTSRHLPDSAIDLLDEAAATVQNKSKHVKADDSDLSPADKALMDGKWKQAAQLIAKEEEVPVYKDLVTESDI
LTTLSRLSGIPVQKLTQTDAKKYLNLEAELHKRVIGQDQAVSSISRAIRRNQSGIRSHKRPIGSFMFLGPTGVGKTELAK
ALAEVLFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQVLDD
GVLTDSKGRKVDFSNTIIIMTSNLGATALRDDKTVGFGAKDIRFDQENMEKRMFEELKKAYRPEFINRIDEKVVFHSLSS
DHMQEVVKIMVKPLVASLAEKGIDLKLQASALKLLANQGYDPEMGARPLRRTLQTEVEDKLAELLLKGDLVAGNTLKIGV
KAGQLKFDIA

Nucleotide


Download         Length: 2433 bp        

>NTDB_id=895254 R4709_RS05675 WP_127245097.1 1097537..1099969(+) (clpC) [Streptococcus pneumoniae strain 16H3071-2]
ATGAACTATTCAAAAGCATTGAATGAATGTATCGAAAGTGCCTACATGGTTGCTGGACATTTTGGAGCTCGTTATCTAGA
GTCTTGGCACTTGTTGATTGCCATGTCTAATCACAGTTATAGTGTAGCAGGGGCAACTTTAAATGATTATCCGTATGAGA
TGGACCGTTTAGAAGAGGTGGCTTTGGAACTGACTGAAACGGACTATAGCCAGGATGAAACTTTTACGGAATTGCCGTTC
TCCCGTCGTTTGCAGATTCTTTTTGACGAAGCAGAGTATGTAGCGTCAGTGGTCCATGCTAAGGTGCTAGGGACAGAGCA
CGTCCTCTATGCGATTTTGCATGATGGCAATGCCTTGGCGACTCGTATCTTGGAGAGGGCTGGTTTTTCTTATGAAGACA
AGAAAGATCAGGTCAAGATTGCTGCTCTTCGTCGAAATTTAGAAGAACGGGCAGGCTGGACTCGTGAAGATCTCAAGGCT
TTACGCCAACGCCATCGTACAGTAGCTGACAAGCAAAATTCTATGGCCAATATGATGGGCATGCCGCAGACTCCTAGTGG
TGGTCTCGAGGACTATACGCATGATTTGACAGAGCAAGCGCGTTCTGGCAAGTTAGAACCAGTCATCGGTCGGGACAAGG
AAATCTCACGTATGATTCAAATCTTGAGCCGGAAGACTAAGAACAACCCTGTCTTGGTTGGGGATGCTGGTGTCGGGAAA
ACAGCTCTGGCCCTTGGTCTTGCTCAGCGTATTGCTAGTGGTGACGTGCCTGCGGAAATGGCTAAGATGCGCGTGTTAGA
ACTTGATTTGATGAATGTCGTTGCAGGGACACGCTTCCGTGGTGACTTTGAAGAACGCATGAATAATATCATCAAGGATA
TTGAAGAAGATGGCCAAGTCATCCTCTTTATCGATGAACTCCACACCATCATGGGTTCTGGTAGCGGGATTGATTCGACT
CTGGATGCGGCCAATATCTTGAAACCAGCCTTGGCGCGTGGAACTTTGAGAACGGTTGGTGCCACCACTCAGGAAGAATA
TCAAAAACATATCGAAAAAGATGCGGCACTTTCTCGTCGTTTCGCTAAAGTGACGATTGAAGAACCAAGTGTGGCAGATA
GTATGACTATTTTACAAGGTTTGAAGGCGACTTATGAGAAACATCACCGTGTACAAATCACAGATGAAGCGGTTGAAACA
GCGGTTAAGATGGCTCATCGTTATTTAACCAGTCGTCACTTGCCAGACTCTGCTATCGATCTCTTGGACGAAGCAGCAGC
AACAGTGCAAAATAAATCAAAGCATGTAAAAGCAGACGATTCTGACTTGAGTCCAGCTGACAAGGCCTTGATGGATGGCA
AGTGGAAACAGGCAGCCCAGCTAATCGCAAAAGAAGAGGAAGTACCTGTCTACAAAGACTTGGTGACAGAGTCTGATATT
TTGACCACCTTGAGTCGCTTGTCAGGAATCCCAGTTCAAAAACTGACTCAAACGGATGCTAAGAAGTATTTAAATCTTGA
AGCAGAACTCCATAAACGGGTTATCGGTCAAGATCAAGCTGTTTCAAGTATTAGTCGTGCGATTCGCCGTAATCAGTCAG
GAATTCGCAGTCACAAGCGTCCGATCGGTTCCTTTATGTTCCTAGGACCCACAGGTGTCGGTAAGACCGAGTTGGCCAAG
GCTTTGGCAGAAGTTCTCTTTGATGACGAATCAGCCCTTATCCGCTTTGATATGAGTGAGTATATGGAGAAATTCGCAGC
CAGCCGTCTAAATGGAGCTCCTCCAGGCTATGTGGGTTACGAAGAAGGTGGGGAGTTGACAGAGAAGGTTCGCAATAAAC
CCTATTCCGTTCTCCTCTTTGATGAGGTAGAGAAGGCCCACCCAGATATCTTTAATGTTCTCTTGCAGGTTCTGGATGAC
GGTGTCTTGACAGATAGCAAGGGACGCAAGGTCGATTTTTCAAATACCATTATCATTATGACATCGAACCTAGGTGCGAC
TGCCCTTCGTGATGATAAGACTGTTGGTTTTGGGGCTAAGGATATTCGTTTTGACCAGGAAAATATGGAAAAACGCATGT
TTGAAGAACTGAAAAAAGCTTATAGACCGGAATTCATCAACCGTATTGATGAGAAGGTGGTCTTCCATAGCCTATCTAGT
GACCATATGCAGGAAGTGGTGAAGATTATGGTCAAGCCTTTAGTGGCAAGTTTGGCTGAAAAAGGCATTGACTTGAAATT
ACAAGCTTCAGCTCTGAAATTGTTAGCAAATCAAGGATATGACCCAGAGATGGGAGCTCGCCCACTTCGCAGAACCCTGC
AAACAGAAGTGGAGGACAAGTTGGCAGAACTTCTTCTTAAGGGAGATTTAGTGGCAGGCAACACACTTAAGATTGGTGTC
AAAGCAGGCCAGTTAAAATTTGATATTGCATAA

Domains

Predicted by InterproScan.

AAA lid domain (AAA_lid_9)

(370-444)

C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small)

(718-797)

Clp amino terminal domain, pathogenicity island component (Clp_N)

(103-139)

ATPase family associated with various cellular activities (AAA) (AAA)

(231-362)

AAA domain (Cdc48 subfamily) (AAA_2)

(540-711)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpC Streptococcus pneumoniae D39

99.63

100

0.996
  clpC Streptococcus pneumoniae Rx1

99.63

100

0.996
  clpC Streptococcus pneumoniae TIGR4

99.383

100

0.994
  clpC Streptococcus mutans UA159

66.913

100

0.672
  clpC Streptococcus thermophilus LMD-9

66.216

100

0.665
  clpC Streptococcus thermophilus LMG 18311

66.093

100

0.664
  clpC Lactococcus lactis subsp. lactis strain DGCC12653

48.918

100

0.502
  clpC Bacillus subtilis subsp. subtilis str. 168

45.365

99.877

0.453
  clpE Streptococcus mutans UA159

49.355

76.543

0.378
  clpE Streptococcus pneumoniae Rx1

47.293

77.531

0.367
  clpE Streptococcus pneumoniae D39

47.293

77.531

0.367
  clpE Streptococcus pneumoniae R6

47.293

77.531

0.367
  clpE Streptococcus pneumoniae TIGR4

47.293

77.531

0.367
  clpC Lactococcus lactis subsp. cremoris KW2

46.955

77.037

0.362