Detailed information NTG0895092

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4703_RS04095
• Genome accession: NZ_CP137100
• Coordinates: 758535..759572 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727268.1
• Uniprot ID: A0A0U0L8C3
• Organism: Streptococcus pneumoniae strain LYP
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 753535..764572

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4703_RS04070	-	754336..755667 (-)	1332	WP_000390048.1	hemolysin family protein	-
R4703_RS04075	endA	755896..756720 (-)	825	WP_001036779.1	DNA-entry nuclease EndA	Machinery gene
R4703_RS04080	-	756759..756947 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
R4703_RS04085	murA	756940..758223 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4703_RS04090	-	758247..758477 (-)	231	WP_000250393.1	DUF1146 family protein	-
R4703_RS04095	sepM	758535..759572 (-)	1038	WP_000727268.1	SepM family pheromone-processing serine protease	Regulator
R4703_RS04100	coaD	759556..760044 (-)	489	WP_001280740.1	pantetheine-phosphate adenylyltransferase	-
R4703_RS04105	rsmD	760034..760573 (-)	540	WP_000706963.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4703_RS04110	asnA	760638..761630 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4703_RS04115	-	761742..762425 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4703_RS04120	-	762481..763221 (-)	741	WP_000152679.1	RNA methyltransferase	-
R4703_RS04125	-	763255..763533 (+)	279	WP_001174613.1	acylphosphatase	-
R4703_RS04130	yidC	763611..764537 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37551.60 Da
• Isoelectric Point: 5.0724

>NTDB_id=895092 R4703_RS04095 WP_000727268.1 758535..759572(-) (sepM) [Streptococcus pneumoniae strain LYP]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKINDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895092 R4703_RS04095 WP_000727268.1 758535..759572(-) (sepM) [Streptococcus pneumoniae strain LYP]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAATAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAGATTATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

• PDZ domain (PDZ_2) (130-193)

3D structure

• AlphaFold DB: A0A0U0L8C3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.357	99.13	0.588