Detailed information NTG0895013

Bioinformatically predicted

Overview

• Name: sepM
• Type: Regulator
• Locus tag: R4714_RS03820
• Genome accession: NZ_CP137099
• Coordinates: 720413..721450 (-)
• Length: 345 a.a.
• NCBI ID: WP_000727277.1
• Uniprot ID: A0A0B7LHQ0
• Organism: Streptococcus pneumoniae strain 20824-4
• Function: processing of CSP (predicted from homology) Competence regulation

Genomic Context

Location: 715413..726450

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4714_RS03795	-	716152..717483 (-)	1332	WP_000390042.1	hemolysin family protein	-
R4714_RS03800	endA	717774..718598 (-)	825	WP_001036781.1	DNA-entry nuclease EndA	Machinery gene
R4714_RS03805	-	718637..718825 (-)	189	WP_001036519.1	DNA-directed RNA polymerase subunit beta	-
R4714_RS03810	murA	718818..720101 (-)	1284	WP_000358028.1	UDP-N-acetylglucosamine 1-carboxyvinyltransferase	-
R4714_RS03815	-	720125..720355 (-)	231	WP_000250384.1	DUF1146 family protein	-
R4714_RS03820	sepM	720413..721450 (-)	1038	WP_000727277.1	SepM family pheromone-processing serine protease	Regulator
R4714_RS03825	coaD	721434..721922 (-)	489	WP_001280769.1	pantetheine-phosphate adenylyltransferase	-
R4714_RS03830	rsmD	721912..722451 (-)	540	WP_001819515.1	16S rRNA (guanine(966)-N(2))-methyltransferase RsmD	-
R4714_RS03835	asnA	722516..723508 (-)	993	WP_000747993.1	aspartate--ammonia ligase	-
R4714_RS03840	-	723620..724303 (-)	684	WP_001016917.1	Bax inhibitor-1/YccA family protein	-
R4714_RS03845	-	724359..725099 (-)	741	WP_000152678.1	RNA methyltransferase	-
R4714_RS03850	-	725133..725411 (+)	279	WP_001174613.1	acylphosphatase	-
R4714_RS03855	yidC	725489..726415 (+)	927	WP_000835941.1	membrane protein insertase YidC	-

Sequence

Protein

• Length: 345 a.a.
• Molecular weight: 37537.57 Da
• Isoelectric Point: 5.0724

>NTDB_id=895013 R4714_RS03820 WP_000727277.1 720413..721450(-) (sepM) [Streptococcus pneumoniae strain 20824-4]
MKKKIRWPLYVIAALIVTFLAFVVPLPYYIEVPGGSEDIRQVLKVNDTEDKEAGAYQFVTVGVQHATLAHMIYAWLTPFT
DIRSAQETTGGSSDVEFMRINQFYMQTSQNMAKYQGLKTAGKDIELKYFGVYVLNVTDNSTFKGILNISDTVTAVNDQTF
DSSKDLIDYVSSQKLGDSVKVTYEEDGQTKSAEGKIITLENGKNGIGIGLIDRTEVISNVPISFSTAGIGGPSAGLMFSL
AIYTQIAHPDLRNGRIVAGTGTIDRDGNVGDIGGIDKKVVASARAGAAIFFAPDNPVSEEEQKAHPDAKNNYQTALEAAK
TIKTDMKIVPVKTLQDAIDYLKNNP

Nucleotide

• Length: 1038 bp

>NTDB_id=895013 R4714_RS03820 WP_000727277.1 720413..721450(-) (sepM) [Streptococcus pneumoniae strain 20824-4]
ATGAAAAAAAAGATTAGATGGCCCTTATACGTCATTGCGGCCTTGATTGTGACTTTCTTGGCATTTGTAGTGCCCTTGCC
TTATTATATAGAGGTTCCAGGTGGTTCGGAAGATATTCGCCAAGTCCTTAAAGTAAATGACACAGAAGATAAGGAAGCTG
GTGCCTATCAATTCGTTACGGTTGGTGTTCAACATGCCACTTTAGCTCATATGATTTATGCTTGGTTGACACCTTTTACA
GATATTCGTAGTGCTCAGGAGACTACAGGTGGTTCTTCCGATGTTGAATTTATGCGAATCAATCAATTCTACATGCAAAC
ATCGCAAAATATGGCCAAGTATCAAGGACTAAAAACAGCTGGTAAGGATATCGAACTCAAGTACTTTGGAGTTTATGTTT
TGAATGTGACGGATAATTCAACCTTTAAAGGGATTCTCAATATCTCTGATACAGTCACAGCAGTCAATGATCAGACCTTT
GATAGTTCCAAAGACTTGATTGATTACGTCAGTTCTCAAAAATTAGGGGATTCCGTCAAGGTCACCTATGAAGAGGATGG
GCAAACCAAGTCTGCAGAAGGAAAAATCATCACCTTGGAAAATGGCAAAAATGGAATTGGAATCGGCTTGATTGACCGTA
CAGAGGTAATCAGCAATGTCCCAATTAGCTTTTCAACAGCTGGTATTGGCGGTCCAAGTGCTGGTCTCATGTTTAGTCTA
GCTATCTATACTCAAATAGCTCACCCAGATCTTCGTAATGGTCGTATTGTTGCCGGTACAGGTACCATTGACCGCGATGG
TAATGTGGGAGACATTGGAGGTATTGATAAGAAGGTTGTAGCTTCGGCTAGGGCAGGTGCTGCTATTTTCTTTGCTCCTG
ATAACCCTGTTAGCGAAGAAGAACAAAAGGCGCATCCGGACGCGAAAAACAACTACCAAACAGCCCTAGAAGCGGCTAAA
ACAATCAAGACGGATATGAAAATCGTGCCCGTTAAAACCCTACAAGATGCGATTGATTACTTGAAAAACAATCCCTAA

Domains

Predicted by InterproScan.

• PDZ domain (PDZ_2) (130-193)

• Lon protease (S16) C-terminal proteolytic domain (Lon_C) (230-296)

3D structure

• AlphaFold DB: A0A0B7LHQ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
sepM	Streptococcus mutans UA159	59.649	99.13	0.591