Detailed information    

insolico Bioinformatically predicted

Overview

Name   cinA   Type   Machinery gene
Locus tag   R3H37_RS08630 Genome accession   NZ_CP136948
Coordinates   1758605..1759876 (-) Length   423 a.a.
NCBI ID   WP_030126182.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Spyo01     
Function   require for competence (predicted from homology)   
Unclear

Genomic Context

Location: 1753605..1764876
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS08605 (R3H37_08610) - 1755574..1755879 (-) 306 WP_002982199.1 DUF1292 domain-containing protein -
  R3H37_RS08610 (R3H37_08615) ruvX 1755891..1756310 (-) 420 WP_002982196.1 Holliday junction resolvase RuvX -
  R3H37_RS08615 (R3H37_08620) - 1756307..1756576 (-) 270 WP_002982194.1 IreB family regulatory phosphoprotein -
  R3H37_RS08620 (R3H37_08625) spx 1756691..1757089 (-) 399 WP_002982188.1 transcriptional regulator Spx -
  R3H37_RS08625 (R3H37_08630) recA 1757380..1758516 (-) 1137 WP_002992179.1 recombinase RecA Machinery gene
  R3H37_RS08630 (R3H37_08635) cinA 1758605..1759876 (-) 1272 WP_030126182.1 competence/damage-inducible protein A Machinery gene
  R3H37_RS08635 (R3H37_08640) - 1759945..1760505 (-) 561 WP_011018314.1 DNA-3-methyladenine glycosylase I -
  R3H37_RS08640 (R3H37_08645) ruvA 1760515..1761111 (-) 597 WP_011285268.1 Holliday junction branch migration protein RuvA -
  R3H37_RS08645 (R3H37_08650) - 1761113..1762333 (-) 1221 WP_053308678.1 MDR family MFS transporter -
  R3H37_RS08650 (R3H37_08655) mutL 1762344..1764326 (-) 1983 WP_053308679.1 DNA mismatch repair endonuclease MutL -

Sequence

Protein


Download         Length: 423 a.a.        Molecular weight: 45989.79 Da        Isoelectric Point: 4.9844

>NTDB_id=893628 R3H37_RS08630 WP_030126182.1 1758605..1759876(-) (cinA) [Streptococcus pyogenes strain Spyo01]
MKAELIAVGTEILTGQIVNTNAQFLSEKMAELGIDVYFQTAVGDNEERLLSVITTASQRSDLVILCGGLGPTKDDLTKQT
LAKYLRKDLVYDKQACQKLDDFFAKRKPSSRTPNNERQAQVIEGSIPLPNKTGLAVGGFITVDGISYVVLPGPPSELKPM
VNEELVPLLSKQYSTLYSKVLRFFGIGESQLVTVLSDFIENQTDPTIAPYAKTGEVTLRLSTKTENQALADKKLGQLEAQ
LLSRKTLEGQPLADVFYGYGEDNSLARETFELLVKYDKTITAAESLTAGLFQSTLASFPGASQVFNGGFVTYSMEEKAKM
LGLPLEELKSHGVVSAYTAEGMAEQARLLTGADIGVSLTGVAGPDMLEEQPAGTVFIGLATQNKVESIKVLISGRSRLDV
RYIATLHAFNMVRKTLLKLENLL

Nucleotide


Download         Length: 1272 bp        

>NTDB_id=893628 R3H37_RS08630 WP_030126182.1 1758605..1759876(-) (cinA) [Streptococcus pyogenes strain Spyo01]
ATGAAAGCTGAACTGATTGCAGTAGGTACCGAAATTTTGACTGGTCAAATTGTGAATACCAATGCTCAATTTCTGTCGGA
AAAAATGGCAGAGCTAGGTATTGATGTCTATTTTCAAACGGCTGTTGGGGACAACGAGGAGCGTTTACTTTCAGTGATTA
CAACTGCTAGTCAGCGTAGTGACTTGGTCATTTTATGCGGTGGCCTTGGTCCAACGAAAGATGATTTAACCAAACAAACT
TTAGCAAAGTACCTTAGGAAAGACTTGGTTTATGATAAGCAAGCTTGTCAGAAACTAGATGACTTTTTTGCTAAGCGCAA
GCCTTCATCACGGACACCAAATAATGAGCGACAGGCACAAGTGATTGAAGGGTCAATCCCTTTGCCAAATAAAACTGGTC
TTGCGGTTGGTGGGTTCATCACAGTCGATGGTATTAGTTATGTTGTCTTACCGGGTCCTCCAAGTGAATTGAAGCCGATG
GTAAATGAAGAATTGGTACCACTTCTGTCAAAACAATACAGTACATTGTATTCAAAGGTACTACGCTTTTTTGGTATTGG
GGAAAGTCAGTTGGTAACAGTCTTGTCAGATTTTATTGAGAATCAAACTGATCCAACCATTGCTCCGTATGCTAAGACTG
GCGAAGTGACTCTTCGCTTATCAACAAAAACTGAAAACCAAGCTCTGGCAGATAAAAAGTTAGGTCAGCTAGAAGCGCAG
CTACTATCCCGAAAAACTCTTGAAGGTCAACCCTTAGCTGATGTCTTTTATGGCTATGGGGAGGATAATTCCTTAGCGCG
TGAGACATTTGAGCTCTTAGTAAAATATGATAAGACAATTACAGCAGCAGAAAGTCTAACCGCGGGATTATTTCAGTCAA
CTTTGGCGAGTTTTCCAGGAGCTTCTCAAGTATTCAATGGAGGCTTTGTGACTTATAGCATGGAAGAAAAAGCGAAAATG
CTAGGCCTTCCTTTAGAGGAGTTGAAATCGCATGGCGTTGTTAGTGCTTATACAGCCGAGGGGATGGCGGAGCAAGCAAG
GTTATTGACTGGTGCTGATATTGGGGTAAGTTTAACAGGTGTTGCCGGACCAGATATGTTGGAGGAACAGCCTGCAGGTA
CAGTTTTCATTGGTCTTGCCACTCAAAATAAGGTAGAATCAATAAAGGTTTTGATTAGCGGGCGAAGTCGTTTGGATGTG
CGCTATATCGCTACTTTACATGCCTTTAATATGGTCCGTAAAACTTTATTAAAACTTGAGAATTTGCTATAA

Domains

Predicted by InterproScan.

Competence-damaged protein (CinA)

(263-416)

Damage-inducible protein CinA KH domain (CinA_KH)

(178-243)

Probable molybdopterin binding domain (MoCF_biosynth)

(5-170)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  cinA Streptococcus mutans UA159

69.976

100

0.7
  cinA Streptococcus mitis SK321

70.024

98.582

0.69
  cinA Streptococcus mitis NCTC 12261

69.544

98.582

0.686
  cinA Streptococcus pneumoniae TIGR4

68.585

98.582

0.676
  cinA Streptococcus pneumoniae Rx1

68.585

98.582

0.676
  cinA Streptococcus pneumoniae R6

68.585

98.582

0.676
  cinA Streptococcus pneumoniae D39

68.345

98.582

0.674
  cinA Streptococcus suis isolate S10

52.885

98.345

0.52
  cinA Bacillus subtilis subsp. subtilis str. 168

46.651

98.818

0.461