Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   R3H37_RS04305 Genome accession   NZ_CP136948
Coordinates   853110..853784 (+) Length   224 a.a.
NCBI ID   WP_002984519.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Spyo01     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 848110..858784
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS04290 (R3H37_04290) pstB 848542..849300 (+) 759 WP_002989690.1 phosphate ABC transporter ATP-binding protein PstB -
  R3H37_RS04295 (R3H37_04295) phoU 849368..850021 (+) 654 WP_002984514.1 phosphate signaling complex protein PhoU -
  R3H37_RS04300 (R3H37_04300) - 850226..852763 (+) 2538 WP_002989692.1 M1 family metallopeptidase -
  R3H37_RS04305 (R3H37_04305) ciaR 853110..853784 (+) 675 WP_002984519.1 response regulator transcription factor Regulator
  R3H37_RS04310 (R3H37_04310) ciaH 853777..855087 (+) 1311 WP_011054528.1 sensor histidine kinase Regulator
  R3H37_RS04315 (R3H37_04315) rpsT 855212..855460 (-) 249 WP_009881183.1 30S ribosomal protein S20 -
  R3H37_RS04320 (R3H37_04320) coaA 855514..856434 (-) 921 WP_023612940.1 type I pantothenate kinase -
  R3H37_RS04325 (R3H37_04325) - 856702..857295 (+) 594 WP_002989699.1 class I SAM-dependent methyltransferase -
  R3H37_RS04330 (R3H37_04330) - 857948..858337 (+) 390 WP_002984531.1 cytidine deaminase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25703.91 Da        Isoelectric Point: 4.7287

>NTDB_id=893607 R3H37_RS04305 WP_002984519.1 853110..853784(+) (ciaR) [Streptococcus pyogenes strain Spyo01]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTRFVNRLQTLRSVGYILKNNE

Nucleotide


Download         Length: 675 bp        

>NTDB_id=893607 R3H37_RS04305 WP_002984519.1 853110..853784(+) (ciaR) [Streptococcus pyogenes strain Spyo01]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTGTTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGTCACGGATTTGAATTAGGTGCTGATGATTATCTGACCAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCCGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGGTATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus mutans UA159

85.135

99.107

0.844
  ciaR Streptococcus pneumoniae D39

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae R6

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae TIGR4

84.685

99.107

0.839
  ciaR Streptococcus pneumoniae Rx1

84.685

99.107

0.839
  covR Lactococcus lactis subsp. lactis strain DGCC12653

39.111

100

0.393
  vicR Streptococcus mutans UA159

35.897

100

0.375
  micA Streptococcus pneumoniae Cp1015

35.47

100

0.371
  covR Streptococcus salivarius strain HSISS4

36.283

100

0.366