Detailed information    

insolico Bioinformatically predicted

Overview

Name   sepM   Type   Regulator
Locus tag   R3H37_RS02990 Genome accession   NZ_CP136948
Coordinates   592076..593113 (+) Length   345 a.a.
NCBI ID   WP_010922499.1    Uniprot ID   A0A4U9I5V9
Organism   Streptococcus pyogenes strain Spyo01     
Function   processing of CSP (predicted from homology)   
Competence regulation

Genomic Context

Location: 587076..598113
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS02965 (R3H37_02965) - 587340..588671 (+) 1332 WP_129284341.1 dipeptidase -
  R3H37_RS02970 (R3H37_02970) arcC 588691..589641 (+) 951 WP_009880962.1 carbamate kinase -
  R3H37_RS02975 (R3H37_02975) asnA 589954..590946 (+) 993 WP_129284342.1 aspartate--ammonia ligase -
  R3H37_RS02980 (R3H37_02980) rsmD 591069..591608 (+) 540 WP_002983819.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  R3H37_RS02985 (R3H37_02985) coaD 591598..592089 (+) 492 WP_014407698.1 pantetheine-phosphate adenylyltransferase -
  R3H37_RS02990 (R3H37_02990) sepM 592076..593113 (+) 1038 WP_010922499.1 SepM family pheromone-processing serine protease Regulator
  R3H37_RS02995 (R3H37_02995) - 593527..594504 (+) 978 WP_002994809.1 LacI family DNA-binding transcriptional regulator -
  R3H37_RS03000 (R3H37_03000) - 594952..595572 (+) 621 WP_038434166.1 YutD family protein -
  R3H37_RS03005 (R3H37_03005) rlmN 595576..596655 (+) 1080 WP_011184761.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  R3H37_RS03010 (R3H37_03010) - 596737..597363 (-) 627 WP_002983834.1 prepilin peptidase -

Sequence

Protein


Download         Length: 345 a.a.        Molecular weight: 37541.24 Da        Isoelectric Point: 9.6692

>NTDB_id=893602 R3H37_RS02990 WP_010922499.1 592076..593113(+) (sepM) [Streptococcus pyogenes strain Spyo01]
MKRLKKIKWWLVGLLALISLLLALFFPLPYYIEMPGGAYDIRTVLQVNGKEDKRKGAYQFVAVGISRASLAQLLYAWLTP
FTEISTAEDTTGGYSDADFLRINQFYMETSQNAAIYQALSLAGKPVTLDYKGVYVLDVNNESTFKGTLHLADTVTGVNGK
QFTSSAELIDYVSHLKLGDEVTVQFTSDNKPKKGVGRIIKLKNGKNGIGIALTDHTSVNSEDTVIFSTKGVGGPSAGLMF
TLDIYDQITKEDLRKGRTIAGTGTIGKDGEVGDIGGAGLKVVAAAEAGADIFFVPNNPVDKEIKKVNPNAISNYEEAKRA
AKRLKTKMKIVPVTTVQEALVYLRK

Nucleotide


Download         Length: 1038 bp        

>NTDB_id=893602 R3H37_RS02990 WP_010922499.1 592076..593113(+) (sepM) [Streptococcus pyogenes strain Spyo01]
ATGAAAAGACTTAAAAAAATCAAATGGTGGTTAGTGGGTCTGCTAGCTTTAATCTCTTTGTTGCTAGCGTTATTTTTTCC
GCTACCTTATTATATTGAAATGCCTGGAGGCGCTTACGATATTCGGACTGTCTTACAAGTCAATGGCAAAGAAGACAAAC
GAAAAGGAGCTTACCAGTTTGTTGCAGTGGGCATTAGTCGTGCCAGCCTCGCTCAGCTATTATATGCTTGGCTGACACCG
TTTACTGAAATTAGTACAGCAGAAGATACAACAGGCGGATACAGCGATGCTGATTTCCTTCGAATTAATCAATTTTACAT
GGAAACATCACAAAATGCAGCTATTTATCAAGCTTTATCCTTAGCTGGAAAACCAGTTACATTAGATTATAAAGGCGTAT
ATGTTTTAGACGTAAACAACGAATCTACTTTTAAAGGAACGCTACACTTAGCAGATACTGTAACAGGTGTAAATGGTAAA
CAGTTTACTAGTTCAGCAGAACTTATTGACTATGTTTCTCACCTAAAACTAGGGGATGAAGTTACGGTTCAGTTTACGAG
TGATAATAAGCCTAAAAAAGGAGTTGGCCGTATTATCAAACTGAAAAATGGGAAAAATGGGATTGGCATTGCCTTGACTG
ATCATACAAGTGTCAATTCAGAAGACACAGTGATCTTTAGTACTAAAGGAGTAGGAGGACCTAGTGCTGGTCTAATGTTT
ACTCTTGATATATATGATCAAATAACTAAAGAAGATTTACGCAAGGGCCGTACAATTGCAGGTACAGGAACTATTGGCAA
GGATGGCGAAGTAGGAGATATTGGTGGTGCAGGTCTTAAAGTAGTTGCAGCAGCTGAAGCTGGTGCAGATATATTTTTTG
TTCCGAATAATCCTGTTGATAAGGAAATTAAAAAAGTTAATCCAAATGCTATAAGTAATTACGAAGAAGCCAAACGGGCA
GCCAAACGACTAAAGACCAAAATGAAGATTGTTCCTGTTACGACTGTTCAAGAGGCACTGGTTTATCTTCGCAAATAA

Domains

Predicted by InterproScan.

Lon protease (S16) C-terminal proteolytic domain (Lon_C)

(233-309)

PDZ domain (PDZ_2)

(129-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A4U9I5V9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  sepM Streptococcus mutans UA159

69.275

100

0.693