Detailed information NTG0884294

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RND68_RS04470
• Genome accession: NZ_CP134882
• Coordinates: 865967..867010 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 10-5-1
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 860967..872010

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RND68_RS04440 (RND68_04440)	-	861466..861576 (+)	111	WP_001790257.1	hypothetical protein	-
RND68_RS04445 (RND68_04445)	-	861605..862018 (+)	414	WP_001643743.1	hypothetical protein	-
RND68_RS04450 (RND68_04450)	-	862207..863193 (-)	987	WP_001014423.1	aromatic acid exporter family protein	-
RND68_RS04455 (RND68_04455)	map	863893..864651 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RND68_RS04460 (RND68_04460)	-	864868..865254 (+)	387	WP_001110178.1	hypothetical protein	-
RND68_RS04465 (RND68_04465)	liaF	865269..865970 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RND68_RS04470 (RND68_04470)	vraS	865967..867010 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RND68_RS04475 (RND68_04475)	vraR	867000..867629 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RND68_RS04480 (RND68_04480)	-	867742..868959 (-)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
RND68_RS04485 (RND68_04485)	-	869237..869512 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RND68_RS04490 (RND68_04490)	-	869519..869983 (-)	465	WP_000228670.1	low molecular weight protein-tyrosine-phosphatase	-
RND68_RS04495 (RND68_04495)	-	870130..870330 (+)	201	WP_000180460.1	DUF1128 family protein	-
RND68_RS04500 (RND68_04500)	-	870333..871589 (+)	1257	WP_001793983.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=884294 RND68_RS04470 WP_001017131.1 865967..867010(+) (vraS) [Staphylococcus aureus strain 10-5-1]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=884294 RND68_RS04470 WP_001017131.1 865967..867010(+) (vraS) [Staphylococcus aureus strain 10-5-1]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGACTT
ATACCATACACTTGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1