Detailed information NTG0882454

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RL452_RS09440
• Genome accession: NZ_CP134620
• Coordinates: 1918597..1919640 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain Sa9
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1913597..1924640

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RL452_RS09410 (RL452_09400)	-	1914018..1915274 (-)	1257	WP_078062667.1	aminopeptidase	-
RL452_RS09415 (RL452_09405)	-	1915277..1915477 (-)	201	WP_011382336.1	DUF1128 family protein	-
RL452_RS09420 (RL452_09410)	-	1915624..1916088 (+)	465	WP_000228664.1	low molecular weight protein-tyrosine-phosphatase	-
RL452_RS09425 (RL452_09415)	-	1916095..1916370 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RL452_RS09430 (RL452_09420)	-	1916648..1917865 (+)	1218	WP_045158466.1	YihY/virulence factor BrkB family protein	-
RL452_RS09435 (RL452_09425)	vraR	1917978..1918607 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
RL452_RS09440 (RL452_09430)	vraS	1918597..1919640 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RL452_RS09445 (RL452_09435)	liaF	1919637..1920338 (-)	702	WP_000149062.1	cell wall-active antibiotics response protein LiaF	-
RL452_RS09450 (RL452_09440)	-	1920353..1920739 (-)	387	WP_001110179.1	hypothetical protein	-
RL452_RS09455 (RL452_09445)	map	1920956..1921714 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RL452_RS09460 (RL452_09450)	-	1922126..1923112 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
RL452_RS09465 (RL452_09455)	-	1923542..1923955 (-)	414	WP_011382337.1	hypothetical protein	-
RL452_RS09470 (RL452_09460)	-	1923984..1924094 (-)	111	WP_042852778.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=882454 RL452_RS09440 WP_001017131.1 1918597..1919640(-) (vraS) [Staphylococcus aureus strain Sa9]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=882454 RL452_RS09440 WP_001017131.1 1918597..1919640(-) (vraS) [Staphylococcus aureus strain Sa9]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTGTTTTTAAATC
TCATCATCATTTTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTACTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTGCAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1