Detailed information NTG0088095

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OCX51_RS10035
• Genome accession: NZ_AP024742
• Coordinates: 2027162..2028205 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 59736
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2022162..2033205

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OCX51_RS10005	-	2022590..2023846 (-)	1257	WP_001793428.1	aminopeptidase	-
OCX51_RS10010	-	2023849..2024049 (-)	201	WP_000180460.1	DUF1128 family protein	-
OCX51_RS10015	-	2024196..2024660 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OCX51_RS10020	-	2024667..2024942 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
OCX51_RS10025	-	2025220..2026431 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
OCX51_RS10030	vraR	2026543..2027172 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
OCX51_RS10035	vraS	2027162..2028205 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OCX51_RS10040	liaF	2028202..2028903 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OCX51_RS10045	-	2028918..2029304 (-)	387	WP_001110179.1	hypothetical protein	-
OCX51_RS10050	map	2029521..2030279 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OCX51_RS10055	-	2030810..2031796 (+)	987	WP_000999713.1	FUSC family protein	-
OCX51_RS10060	-	2032286..2032699 (-)	414	WP_001837236.1	hypothetical protein	-
OCX51_RS10065	-	2032728..2032839 (-)	112	Protein_1947	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=88095 OCX51_RS10035 WP_001017131.1 2027162..2028205(-) (vraS) [Staphylococcus aureus strain 59736]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=88095 OCX51_RS10035 WP_001017131.1 2027162..2028205(-) (vraS) [Staphylococcus aureus strain 59736]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1