Detailed information NTG0088051

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OCX20_RS10020
• Genome accession: NZ_AP024738
• Coordinates: 2023957..2025000 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 59731
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2018957..2030000

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OCX20_RS09990	-	2019385..2020641 (-)	1257	WP_001793428.1	aminopeptidase	-
OCX20_RS09995	-	2020644..2020844 (-)	201	WP_000180460.1	DUF1128 family protein	-
OCX20_RS10000	-	2020991..2021455 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OCX20_RS10005	-	2021462..2021737 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
OCX20_RS10010	-	2022015..2023226 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
OCX20_RS10015	vraR	2023338..2023967 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
OCX20_RS10020	vraS	2023957..2025000 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OCX20_RS10025	liaF	2024997..2025698 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OCX20_RS10030	-	2025713..2026099 (-)	387	WP_001110179.1	hypothetical protein	-
OCX20_RS10035	map	2026316..2027074 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OCX20_RS10040	-	2027605..2028591 (+)	987	WP_000999713.1	FUSC family protein	-
OCX20_RS10045	-	2029081..2029494 (-)	414	WP_001837236.1	hypothetical protein	-
OCX20_RS10050	-	2029523..2029634 (-)	112	Protein_1946	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=88051 OCX20_RS10020 WP_001017131.1 2023957..2025000(-) (vraS) [Staphylococcus aureus strain 59731]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=88051 OCX20_RS10020 WP_001017131.1 2023957..2025000(-) (vraS) [Staphylococcus aureus strain 59731]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1