Detailed information NTG0880234

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: RJW49_RS09290
• Genome accession: NZ_CP134477
• Coordinates: 1842000..1844453 (-)
• Length: 817 a.a.
• NCBI ID: WP_012027858.1
• Uniprot ID: A0A2K1SY42
• Organism: Streptococcus suis strain NLS40
• Function: degradation of ComW (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1838102..1859312	1842000..1844453	within	0

Gene organization within MGE regions

Location: 1838102..1859312

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RJW49_RS09270 (RJW49_09270)	dusB	1838102..1839106 (+)	1005	WP_002937787.1	tRNA dihydrouridine synthase DusB	-
RJW49_RS09275 (RJW49_09275)	-	1839252..1840025 (-)	774	WP_012027854.1	NUDIX domain-containing protein	-
RJW49_RS09280 (RJW49_09280)	pnuC	1840018..1840839 (-)	822	WP_012027855.1	nicotinamide riboside transporter PnuC	-
RJW49_RS09285 (RJW49_09285)	-	1840849..1841886 (-)	1038	WP_012028524.1	AAA family ATPase	-
RJW49_RS09290 (RJW49_09290)	clpC	1842000..1844453 (-)	2454	WP_012027858.1	ATP-dependent Clp protease ATP-binding subunit	Regulator
RJW49_RS09295 (RJW49_09295)	-	1844459..1844917 (-)	459	WP_012027859.1	CtsR family transcriptional regulator	-
RJW49_RS09300 (RJW49_09300)	-	1845067..1845405 (+)	339	WP_012027860.1	thioredoxin domain-containing protein	-
RJW49_RS09305 (RJW49_09305)	-	1845405..1846106 (+)	702	WP_012027861.1	hypothetical protein	-
RJW49_RS09310 (RJW49_09310)	tsf	1846260..1847300 (-)	1041	WP_014736447.1	translation elongation factor Ts	-
RJW49_RS09315 (RJW49_09315)	rpsB	1847454..1848230 (-)	777	WP_012775356.1	30S ribosomal protein S2	-
RJW49_RS09320 (RJW49_09320)	-	1848578..1849090 (-)	513	WP_014736448.1	adenylate kinase	-
RJW49_RS09330 (RJW49_09330)	-	1849744..1854813 (-)	5070	WP_074393573.1	S8 family serine peptidase	-
RJW49_RS09335 (RJW49_09335)	nusG	1854957..1855496 (-)	540	WP_074393572.1	transcription termination/antitermination protein NusG	-
RJW49_RS09340 (RJW49_09340)	secE	1855606..1855782 (-)	177	WP_002940255.1	preprotein translocase subunit SecE	-
RJW49_RS09345 (RJW49_09345)	rpmG	1855792..1855944 (-)	153	WP_002940258.1	50S ribosomal protein L33	-
RJW49_RS09350 (RJW49_09350)	pbp2a	1855978..1858191 (-)	2214	WP_014736451.1	penicillin-binding protein PBP2A	-
RJW49_RS09355 (RJW49_09355)	-	1858344..1859312 (+)	969	WP_074393571.1	NAD(P)/FAD-dependent oxidoreductase	-

Sequence

Protein

• Length: 817 a.a.
• Molecular weight: 90132.53 Da
• Isoelectric Point: 6.3138

>NTDB_id=880234 RJW49_RS09290 WP_012027858.1 1842000..1844453(-) (clpC) [Streptococcus suis strain NLS40]
MKISRGLQGVYEDAQLIAQRYSSDYLETWHLLLAFVINPDTVAGAILAEYPADVLDYERAVYMVMGRRYHEELESFFFLP
SSKRVKELQVFAEKIAEIVKSKGLGTEHIFMGMLLDKRSTASQILDQVGFHFEDSDDKVRFLDLRKNLEAKAGFTKEHLK
AIRTMTKGGKPKQATVGNMMGMTQSQSGGLEDYTRDLTALARSGQLEPVIGRDEEISRMLQILSRKTKNNPVLVGDAGVG
KTALALGLAQRIANGEVPASLVNMRILELDLMNVIAGTRFRGDFEERMNNIINDIEEDGRVILFIDELHTIMGSGSGIDS
ILDAANILKPALSRGTLRTVGATTQDEYQKHIEKDAALVRRFAKVTIEEPSVADSVAILQGLKPAYEAHHKVTISDQAVV
TAVAYAKRYLTSKNLPDSAIDLLDEASATVQNRAKGQVEEGGLTALDQALMAGKYKTVTQLLLKAQEAENQATSYSLEVT
EEDILATLSRLSGIPVTKLSQTDAKKYLNLEQELHKRVIGQEEAISAVSRAIRRNQSGIRTGHRPIGSFMFLGPTGVGKT
ELAKALAEILFDDESALIRFDMSEYMEKFAASRLNGAPPGYVGYEEGGELTEKVRNKPYSVLLFDEVEKAHPDIFNVLLQ
VLDDGVLTDRKGRKVDFSNTVIIMTSNLGATALRDDKTVGFGALDLSKSQEHVEKRIFEALKKAYRPEFINRIDEKVVFH
SLTEADMQDVVKVMVKPLIAVAASKGITLKLQASALKLLAKEGYDPEMGARPLRRLLQTKLEDPLAEMLLRGELPAGVTL
KVGVKAEQLKFDSVKAG

Nucleotide

• Length: 2454 bp

>NTDB_id=880234 RJW49_RS09290 WP_012027858.1 1842000..1844453(-) (clpC) [Streptococcus suis strain NLS40]
ATGAAGATTTCAAGAGGGTTACAGGGTGTCTATGAAGATGCTCAATTGATTGCACAGCGTTATAGTAGTGACTATTTGGA
GACCTGGCACTTGTTGTTAGCCTTTGTCATCAATCCAGATACCGTTGCGGGAGCTATTTTAGCAGAATATCCTGCGGATG
TATTGGACTATGAACGTGCAGTTTATATGGTGATGGGGCGGCGTTACCATGAAGAGTTAGAGAGCTTTTTCTTTCTTCCA
TCGTCCAAGCGGGTGAAGGAATTGCAGGTCTTTGCCGAGAAGATTGCGGAGATTGTCAAGAGTAAGGGGCTAGGAACGGA
GCATATTTTCATGGGAATGCTCTTGGACAAGCGTTCGACTGCCTCACAAATTCTGGATCAGGTCGGTTTTCACTTTGAGG
ATTCGGATGATAAGGTTCGTTTTCTGGATTTGCGGAAAAATCTGGAAGCCAAGGCTGGCTTTACCAAGGAGCATCTGAAG
GCTATCCGCACCATGACGAAAGGTGGCAAGCCCAAGCAGGCAACGGTTGGCAATATGATGGGCATGACCCAGTCACAAAG
TGGTGGCTTGGAAGACTATACACGTGATTTGACGGCTTTGGCCCGCTCAGGTCAGTTGGAGCCAGTCATCGGACGGGATG
AGGAAATTTCCCGTATGCTTCAGATTTTGTCGCGGAAAACCAAGAACAATCCTGTCTTGGTTGGAGATGCGGGTGTTGGG
AAAACAGCTCTGGCACTGGGTCTAGCCCAGCGGATTGCTAATGGAGAGGTGCCAGCTAGTCTTGTCAATATGCGGATCTT
GGAATTGGACTTGATGAATGTCATTGCGGGAACGCGTTTCCGTGGGGATTTTGAGGAGCGGATGAACAATATCATCAACG
ATATTGAAGAAGATGGTCGAGTGATTCTCTTCATTGATGAACTCCATACCATTATGGGATCGGGGTCAGGGATTGACTCG
ATCCTGGATGCTGCCAATATTTTGAAGCCTGCTCTGTCCCGTGGGACTTTGCGGACAGTTGGAGCAACGACTCAGGATGA
ATACCAGAAGCATATTGAAAAAGATGCTGCCTTGGTACGTCGATTTGCCAAGGTGACCATTGAGGAACCGAGTGTAGCAG
ACAGCGTAGCAATTTTGCAGGGGTTGAAGCCAGCCTATGAGGCTCACCACAAGGTGACCATTTCGGATCAGGCGGTGGTA
ACGGCGGTAGCCTATGCCAAACGCTATCTGACCAGTAAGAATTTGCCAGATTCGGCTATTGATTTGCTGGATGAAGCCAG
TGCGACGGTTCAAAATCGTGCCAAGGGACAGGTAGAAGAAGGTGGATTGACCGCTTTAGACCAAGCCTTGATGGCTGGGA
AATACAAGACGGTAACGCAGCTCTTGCTTAAGGCTCAAGAGGCGGAAAATCAGGCGACTAGCTATAGCTTGGAAGTCACA
GAAGAAGACATTTTGGCAACCCTCAGTCGCTTGTCAGGTATTCCTGTCACCAAACTGAGTCAGACAGATGCCAAGAAGTA
CCTTAATCTTGAACAGGAATTGCACAAGCGTGTTATCGGGCAGGAAGAGGCGATTTCAGCTGTCAGCCGGGCAATTCGCC
GCAACCAGTCAGGCATTCGCACTGGTCACAGACCGATTGGTTCCTTTATGTTCTTGGGGCCAACAGGTGTCGGTAAGACA
GAATTGGCCAAGGCCTTGGCGGAGATCCTCTTTGATGACGAATCTGCCTTGATTCGTTTTGATATGAGTGAGTATATGGA
GAAATTTGCGGCTAGTCGCCTCAACGGTGCTCCTCCAGGCTATGTTGGCTATGAAGAAGGGGGCGAGCTGACAGAAAAAG
TTCGCAACAAGCCATACTCTGTCCTACTTTTTGATGAGGTGGAGAAAGCACATCCAGATATTTTCAATGTTCTTTTGCAG
GTCTTGGATGACGGTGTCTTGACGGACAGAAAAGGTCGCAAGGTTGATTTCTCTAATACGGTCATCATTATGACGTCTAA
CTTAGGGGCAACCGCTTTACGTGATGATAAGACAGTTGGGTTTGGGGCTCTTGATTTGTCTAAGAGTCAGGAGCACGTTG
AAAAACGGATTTTTGAGGCGTTGAAGAAGGCCTATCGTCCTGAATTTATTAACCGGATTGATGAAAAAGTGGTCTTCCAT
AGCCTGACAGAAGCAGATATGCAGGATGTGGTCAAGGTCATGGTCAAACCATTGATTGCCGTGGCGGCCAGCAAGGGTAT
TACCCTCAAATTGCAGGCTTCTGCTCTTAAACTCTTGGCCAAAGAAGGCTACGATCCAGAAATGGGTGCCCGCCCACTTC
GTCGCCTCCTCCAAACCAAGTTGGAAGATCCATTGGCAGAAATGCTCTTACGTGGAGAACTGCCAGCTGGTGTGACCTTA
AAAGTAGGGGTCAAGGCCGAGCAGTTGAAGTTTGATAGTGTGAAAGCAGGTTAG

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (14-54)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (104-130)

• ATPase family associated with various cellular activities (AAA) (AAA) (232-364)

• AAA domain (Cdc48 subfamily) (AAA_2) (544-715)

• AAA lid domain (AAA_lid_9) (371-451)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (722-802)

3D structure

• AlphaFold DB: A0A2K1SY42

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Streptococcus pneumoniae TIGR4	71.464	99.51	0.711
clpC	Streptococcus pneumoniae Rx1	71.464	99.51	0.711
clpC	Streptococcus pneumoniae D39	71.464	99.51	0.711
clpC	Streptococcus mutans UA159	66.173	99.143	0.656
clpC	Streptococcus thermophilus LMG 18311	64.828	99.878	0.647
clpC	Streptococcus thermophilus LMD-9	64.706	99.878	0.646
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	48.086	100	0.492
clpC	Bacillus subtilis subsp. subtilis str. 168	44.403	99.51	0.442