Detailed information NTG0087974

Bioinformatically predicted

Overview

• Name: ccrA
• Type: Machinery gene
• Locus tag: OCX48_RS00205
• Genome accession: NZ_AP024736
• Coordinates: 48139..49488 (-)
• Length: 449 a.a.
• NCBI ID: WP_000815640.1
• Uniprot ID: -
• Organism: Staphylococcus aureus strain 59709
• Function: promote SCCmec transfer (predicted from homology) Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
SCCmec	39722..54985	48139..49488	within	0

Gene organization within MGE regions

Location: 39722..54985

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OCX48_RS00165	mecA	39722..41732 (-)	2011	Protein_30	PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA	-
OCX48_RS00170	-	41829..42815 (+)	987	WP_001549960.1	beta-lactam sensor/signal transducer MecR1	-
OCX48_RS00175	-	42805..43047 (+)	243	Protein_32	type I restriction enzyme endonuclease domain-containing protein	-
OCX48_RS00180	-	43038..44649 (-)	1612	Protein_33	IS1182 family transposase	-
OCX48_RS00185	-	44698..45204 (-)	507	WP_001092189.1	DUF1643 domain-containing protein	-
OCX48_RS00190	-	45219..45530 (-)	312	WP_000700851.1	DUF960 family protein	-
OCX48_RS00195	-	45617..45967 (-)	351	WP_000849672.1	SAUGI family uracil-DNA glycosylase inhibitor	-
OCX48_RS00200	ccrB	46489..48117 (-)	1629	WP_001186608.1	cassette chromosome recombinase CcrB	Machinery gene
OCX48_RS00205	ccrA	48139..49488 (-)	1350	WP_000815640.1	cassette chromosome recombinase CcrA	Machinery gene
OCX48_RS00210	cch1	49722..51509 (-)	1788	WP_000122620.1	cassette chromosome replicative helicase	-
OCX48_RS00215	ssb	51509..51799 (-)	291	WP_001036438.1	cassette chromosome ssDNA-binding protein	-
OCX48_RS00220	-	51938..52987 (+)	1050	WP_000613248.1	hypothetical protein	-
OCX48_RS00225	-	53495..54985 (+)	1491	WP_261921137.1	RNA-binding domain-containing protein	-

Sequence

Protein

• Length: 449 a.a.
• Molecular weight: 52663.34 Da
• Isoelectric Point: 9.9639

>NTDB_id=87974 OCX48_RS00205 WP_000815640.1 48139..49488(-) (ccrA) [Staphylococcus aureus strain 59709]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQITQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRLKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGTFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRLQKQTKQTPSDNQLKQKIKCPCCNATLTNMTIRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CRDFYQNQRIYTKIKSAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHIIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA

Nucleotide

• Length: 1350 bp

>NTDB_id=87974 OCX48_RS00205 WP_000815640.1 48139..49488(-) (ccrA) [Staphylococcus aureus strain 59709]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAAGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGTCGCAAAGATAATCGTAGTGGGT
ATCGACAAATAACACAATTAATTCAACAAGGACAGTGTGACATATTATGCTGTTATCGTCTTAATAGGTTGCATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACGTACCATGTTCATATCTTAAGCGTACATGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGACTCAAGCTTAATATCTTCATCAGTTTAGCCGAACTTGAATCGGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACACATGCACCTTTTGGTTACGAATATCAC
AACGGAACATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATTGCAAAAACAAACCAAACAGACACCTTCGGATAATCAACTCAAACAAAAAATCAA
ATGCCCATGTTGTAATGCAACACTTACAAATATGACCATTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCACGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCCGAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAAGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATTGATGCAGAAACGTTCA
GAGAGCAAACACAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGGCATCAAATACAACACATCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATTGTCAATCAAACCATGCAATCATCGATTGCATAA

Domains

Predicted by InterproScan.

• Resolvase, N terminal domain (Resolvase) (4-147)

• Recombinase zinc beta ribbon domain (Zn_ribbon_recom) (262-321)

• Recombinase (Recombinase) (169-248)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ccrA	Staphylococcus aureus N315	97.55	100	0.976
ccrA	Staphylococcus aureus COL	75.947	100	0.759