Detailed information NTG0878661

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RI106_RS00470
• Genome accession: NZ_CP134071
• Coordinates: 83440..84483 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 4233
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 78440..89483

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RI106_RS00440 (RI106_00440)	-	78925..79035 (+)	111	WP_001790257.1	hypothetical protein	-
RI106_RS00445 (RI106_00445)	-	79064..79477 (+)	414	WP_001566709.1	hypothetical protein	-
RI106_RS00450 (RI106_00450)	-	79908..80894 (-)	987	WP_000999713.1	aromatic acid exporter family protein	-
RI106_RS00455 (RI106_00455)	map	81366..82124 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RI106_RS00460 (RI106_00460)	-	82341..82727 (+)	387	WP_001110179.1	hypothetical protein	-
RI106_RS00465 (RI106_00465)	liaF	82742..83443 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RI106_RS00470 (RI106_00470)	vraS	83440..84483 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RI106_RS00475 (RI106_00475)	vraR	84473..85102 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RI106_RS00480 (RI106_00480)	-	85214..86431 (-)	1218	WP_000037079.1	YihY/virulence factor BrkB family protein	-
RI106_RS00485 (RI106_00485)	-	86709..86984 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RI106_RS00490 (RI106_00490)	-	86991..87455 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RI106_RS00495 (RI106_00495)	-	87602..87802 (+)	201	WP_000180460.1	DUF1128 family protein	-
RI106_RS00500 (RI106_00500)	-	87805..89061 (+)	1257	WP_310745921.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=878661 RI106_RS00470 WP_001017131.1 83440..84483(+) (vraS) [Staphylococcus aureus strain 4233]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=878661 RI106_RS00470 WP_001017131.1 83440..84483(+) (vraS) [Staphylococcus aureus strain 4233]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACTCAAATATTTGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1