Detailed information NTG0878344

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RE424_RS10130
• Genome accession: NZ_CP134047
• Coordinates: 2021505..2022548 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 21SAU_AGRO3
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2016505..2027548

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RE424_RS10100	-	2016927..2018183 (-)	1257	WP_258415620.1	aminopeptidase	-
RE424_RS10105	-	2018186..2018386 (-)	201	WP_000180460.1	DUF1128 family protein	-
RE424_RS10110	-	2018533..2018997 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RE424_RS10115	-	2019004..2019279 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RE424_RS10120	-	2019557..2020774 (+)	1218	WP_000037078.1	YihY/virulence factor BrkB family protein	-
RE424_RS10125	vraR	2020886..2021515 (-)	630	WP_000153530.1	two-component system response regulator VraR	Regulator
RE424_RS10130	vraS	2021505..2022548 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RE424_RS10135	liaF	2022545..2023246 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RE424_RS10140	-	2023261..2023647 (-)	387	WP_001110179.1	hypothetical protein	-
RE424_RS10145	map	2023864..2024622 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RE424_RS10150	-	2025094..2026080 (+)	987	WP_023914846.1	aromatic acid exporter family protein	-
RE424_RS10155	-	2026511..2026924 (-)	414	Protein_1957	hypothetical protein	-
RE424_RS10160	-	2026953..2027064 (-)	112	Protein_1958	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=878344 RE424_RS10130 WP_001017131.1 2021505..2022548(-) (vraS) [Staphylococcus aureus strain 21SAU_AGRO3]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=878344 RE424_RS10130 WP_001017131.1 2021505..2022548(-) (vraS) [Staphylococcus aureus strain 21SAU_AGRO3]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
TATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1