Detailed information NTG0087834

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OCX18_RS09705
• Genome accession: NZ_AP024728
• Coordinates: 1979472..1980515 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 59553
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1974472..1985515

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OCX18_RS09675	-	1974900..1976156 (-)	1257	WP_001793428.1	aminopeptidase	-
OCX18_RS09680	-	1976159..1976359 (-)	201	WP_000180460.1	DUF1128 family protein	-
OCX18_RS09685	-	1976506..1976970 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OCX18_RS09690	-	1976977..1977252 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
OCX18_RS09695	-	1977530..1978741 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
OCX18_RS09700	vraR	1978853..1979482 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
OCX18_RS09705	vraS	1979472..1980515 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OCX18_RS09710	liaF	1980512..1981213 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OCX18_RS09715	-	1981228..1981614 (-)	387	WP_001110179.1	hypothetical protein	-
OCX18_RS09720	map	1981831..1982589 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OCX18_RS09725	-	1983120..1984106 (+)	987	WP_000999713.1	FUSC family protein	-
OCX18_RS09730	-	1984596..1985009 (-)	414	WP_001837236.1	hypothetical protein	-
OCX18_RS09735	-	1985038..1985149 (-)	112	Protein_1883	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=87834 OCX18_RS09705 WP_001017131.1 1979472..1980515(-) (vraS) [Staphylococcus aureus strain 59553]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=87834 OCX18_RS09705 WP_001017131.1 1979472..1980515(-) (vraS) [Staphylococcus aureus strain 59553]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1