Detailed information NTG0087749

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: OCX22_RS10025
• Genome accession: NZ_AP024723
• Coordinates: 2022659..2023702 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain 59458
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2017659..2028702

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
OCX22_RS09995 (SA59458_18960)	-	2018087..2019343 (-)	1257	WP_001793428.1	aminopeptidase	-
OCX22_RS10000 (SA59458_18970)	-	2019346..2019546 (-)	201	WP_000180460.1	DUF1128 family protein	-
OCX22_RS10005 (SA59458_18980)	-	2019693..2020157 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
OCX22_RS10010 (SA59458_18990)	-	2020164..2020439 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
OCX22_RS10015 (SA59458_19000)	-	2020717..2021928 (+)	1212	WP_000037091.1	YihY/virulence factor BrkB family protein	-
OCX22_RS10020 (SA59458_19010)	vraR	2022040..2022669 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
OCX22_RS10025 (SA59458_19020)	vraS	2022659..2023702 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
OCX22_RS10030 (SA59458_19030)	liaF	2023699..2024400 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
OCX22_RS10035 (SA59458_19040)	-	2024415..2024801 (-)	387	WP_001110179.1	hypothetical protein	-
OCX22_RS10040 (SA59458_19050)	map	2025018..2025776 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
OCX22_RS10045 (SA59458_19060)	-	2026306..2027292 (+)	987	WP_000999713.1	aromatic acid exporter family protein	-
OCX22_RS10050 (SA59458_19070)	-	2027782..2028195 (-)	414	WP_001837236.1	hypothetical protein	-
OCX22_RS10055	-	2028224..2028335 (-)	112	Protein_1945	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=87749 OCX22_RS10025 WP_001017131.1 2022659..2023702(-) (vraS) [Staphylococcus aureus strain 59458]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=87749 OCX22_RS10025 WP_001017131.1 2022659..2023702(-) (vraS) [Staphylococcus aureus strain 59458]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAATTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCGATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1