Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | RGC89_RS00280 | Genome accession | NZ_CP133663 |
| Coordinates | 61714..63060 (-) | Length | 448 a.a. |
| NCBI ID | WP_000816499.1 | Uniprot ID | Q9R3W9 |
| Organism | Staphylococcus epidermidis strain AR4072 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 34335..84117 | 61714..63060 | within | 0 |
| SCCmec | 41902..96866 | 61714..63060 | within | 0 |
Gene organization within MGE regions
Location: 34335..96866
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RGC89_RS00140 (RGC89_00140) | - | 34335..35009 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| RGC89_RS00145 (RGC89_00145) | mobV | 35259..36521 (-) | 1263 | WP_000119405.1 | MobV family relaxase | - |
| RGC89_RS00150 (RGC89_00150) | bleO | 37028..37432 (-) | 405 | WP_001242578.1 | bleomycin binding protein | - |
| RGC89_RS00155 (RGC89_00155) | aadD1 | 37649..38419 (-) | 771 | WP_001795128.1 | aminoglycoside O-nucleotidyltransferase ANT(4')-Ia | - |
| RGC89_RS00160 (RGC89_00160) | - | 38612..39286 (-) | 675 | WP_001106057.1 | IS6-like element IS257 family transposase | - |
| RGC89_RS00165 (RGC89_00165) | - | 39322..39711 (+) | 390 | WP_020444595.1 | hydroxymethylglutaryl-CoA synthase | - |
| RGC89_RS00170 (RGC89_00170) | - | 40588..41331 (+) | 744 | WP_000958858.1 | glycerophosphoryl diester phosphodiesterase | - |
| RGC89_RS00175 (RGC89_00175) | - | 41428..41856 (+) | 429 | WP_000872606.1 | MaoC family dehydratase | - |
| RGC89_RS00180 (RGC89_00180) | mecA | 41902..43911 (-) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
| RGC89_RS00185 (RGC89_00185) | mecR1 | 44008..45765 (+) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| RGC89_RS00190 (RGC89_00190) | mecI | 45765..46136 (+) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| RGC89_RS00195 (RGC89_00195) | psm-mec | 46221..46289 (-) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| RGC89_RS00200 (RGC89_00200) | - | 46623..47753 (+) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| RGC89_RS00205 (RGC89_00205) | cstB | 47867..49201 (-) | 1335 | Protein_38 | persulfide dioxygenase-sulfurtransferase CstB | - |
| RGC89_RS00210 (RGC89_00210) | - | 49234..50298 (-) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| RGC89_RS00215 (RGC89_00215) | cstR | 50434..50694 (+) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| RGC89_RS00220 (RGC89_00220) | - | 50694..51332 (+) | 639 | Protein_41 | sulfite exporter TauE/SafE family protein | - |
| RGC89_RS00225 (RGC89_00225) | - | 51606..52222 (-) | 617 | Protein_42 | CadD family cadmium resistance transporter | - |
| RGC89_RS00230 (RGC89_00230) | - | 52303..54717 (-) | 2415 | WP_000378485.1 | cadmium-translocating P-type ATPase CadA | - |
| RGC89_RS00235 (RGC89_00235) | - | 54710..55075 (-) | 366 | WP_000159127.1 | metalloregulator ArsR/SmtB family transcription factor | - |
| RGC89_RS00240 (RGC89_00240) | - | 55313..55690 (-) | 378 | WP_001041908.1 | DUF6262 family protein | - |
| RGC89_RS00245 (RGC89_00245) | - | 55697..57589 (-) | 1893 | WP_002485298.1 | site-specific integrase | - |
| RGC89_RS00250 (RGC89_00250) | - | 57784..58107 (-) | 324 | WP_000088091.1 | JAB domain-containing protein | - |
| RGC89_RS00255 (RGC89_00255) | - | 58100..58306 (-) | 207 | WP_001077283.1 | hypothetical protein | - |
| RGC89_RS00260 (RGC89_00260) | - | 58308..58829 (-) | 522 | WP_000836008.1 | DUF1643 domain-containing protein | - |
| RGC89_RS00265 (RGC89_00265) | - | 58848..59159 (-) | 312 | WP_000833212.1 | DUF960 family protein | - |
| RGC89_RS00270 (RGC89_00270) | - | 59244..59594 (-) | 351 | WP_000171449.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| RGC89_RS00275 (RGC89_00275) | ccrB | 60065..61693 (-) | 1629 | WP_001186596.1 | cassette chromosome recombinase CcrB | Machinery gene |
| RGC89_RS00280 (RGC89_00280) | ccrA | 61714..63060 (-) | 1347 | WP_000816499.1 | cassette chromosome recombinase CcrA | Machinery gene |
| RGC89_RS00285 (RGC89_00285) | - | 63253..63528 (-) | 276 | WP_001791132.1 | hypothetical protein | - |
| RGC89_RS00290 (RGC89_00290) | cch1 | 63618..65405 (-) | 1788 | WP_000181743.1 | cassette chromosome replicative helicase | - |
| RGC89_RS00295 (RGC89_00295) | ssb | 65405..65689 (-) | 285 | WP_000659554.1 | cassette chromosome ssDNA-binding protein | - |
| RGC89_RS00300 (RGC89_00300) | - | 65827..66876 (+) | 1050 | WP_000613217.1 | hypothetical protein | - |
| RGC89_RS00305 (RGC89_00305) | - | 66929..67501 (+) | 573 | WP_000489177.1 | ADP-ribosyltransferase | - |
| RGC89_RS00310 (RGC89_00310) | - | 67833..68159 (+) | 327 | WP_000624048.1 | helix-turn-helix domain-containing protein | - |
| RGC89_RS00315 (RGC89_00315) | - | 68196..69029 (+) | 834 | WP_000694291.1 | CPBP family intramembrane glutamic endopeptidase | - |
| RGC89_RS00320 (RGC89_00320) | - | 69234..69398 (+) | 165 | WP_001028954.1 | hypothetical protein | - |
| RGC89_RS00325 (RGC89_00325) | - | 69715..70488 (+) | 774 | WP_000998885.1 | hypothetical protein | - |
| RGC89_RS00330 (RGC89_00330) | - | 70726..71085 (-) | 360 | WP_000432280.1 | DUF4870 domain-containing protein | - |
| RGC89_RS00335 (RGC89_00335) | - | 71250..72320 (-) | 1071 | WP_001054882.1 | nitronate monooxygenase family protein | - |
| RGC89_RS00340 (RGC89_00340) | - | 72333..73199 (-) | 867 | WP_001052247.1 | LysR family transcriptional regulator | - |
| RGC89_RS00345 (RGC89_00345) | - | 73186..74376 (-) | 1191 | WP_000716034.1 | YbfB/YjiJ family MFS transporter | - |
| RGC89_RS00350 (RGC89_00350) | - | 74587..75261 (+) | 675 | Protein_67 | IS6 family transposase | - |
| RGC89_RS00355 (RGC89_00355) | - | 75321..75749 (-) | 429 | WP_000671997.1 | VOC family protein | - |
| RGC89_RS00360 (RGC89_00360) | - | 75830..76759 (+) | 930 | WP_002504713.1 | YafY family protein | - |
| RGC89_RS00365 (RGC89_00365) | - | 76921..78933 (+) | 2013 | WP_012088687.1 | hypothetical protein | - |
| RGC89_RS00370 (RGC89_00370) | - | 79103..80212 (+) | 1110 | WP_002437509.1 | DNA polymerase | - |
| RGC89_RS00375 (RGC89_00375) | - | 80205..80576 (+) | 372 | WP_002437511.1 | hypothetical protein | - |
| RGC89_RS00380 (RGC89_00380) | - | 80573..82216 (+) | 1644 | WP_002504708.1 | DUF5906 domain-containing protein | - |
| RGC89_RS00385 (RGC89_00385) | ccrC | 82441..84117 (+) | 1677 | WP_002504707.1 | cassette chromosome recombinase CcrC | - |
| RGC89_RS00390 (RGC89_00390) | - | 84223..84561 (+) | 339 | WP_000171557.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| RGC89_RS00395 (RGC89_00395) | - | 84657..84968 (+) | 312 | WP_001083108.1 | DUF960 family protein | - |
| RGC89_RS00400 (RGC89_00400) | - | 84984..85490 (+) | 507 | WP_000849085.1 | DUF1643 domain-containing protein | - |
| RGC89_RS00405 (RGC89_00405) | - | 85511..85957 (+) | 447 | WP_002504705.1 | RadC family protein | - |
| RGC89_RS00410 (RGC89_00410) | - | 86127..86999 (+) | 873 | WP_000373149.1 | HTH domain-containing protein | - |
| RGC89_RS00415 (RGC89_00415) | - | 87056..87346 (+) | 291 | WP_000065261.1 | hypothetical protein | - |
| RGC89_RS00420 (RGC89_00420) | - | 87362..87850 (+) | 489 | WP_000393586.1 | hypothetical protein | - |
| RGC89_RS00425 (RGC89_00425) | - | 87985..88512 (+) | 528 | WP_002504704.1 | hypothetical protein | - |
| RGC89_RS00430 (RGC89_00430) | - | 88574..89017 (+) | 444 | WP_000941333.1 | hypothetical protein | - |
| RGC89_RS00435 (RGC89_00435) | - | 88966..89187 (+) | 222 | WP_002504703.1 | hypothetical protein | - |
| RGC89_RS00440 (RGC89_00440) | - | 89581..89904 (+) | 324 | WP_001176049.1 | PepSY domain-containing protein | - |
| RGC89_RS00445 (RGC89_00445) | - | 89982..93101 (-) | 3120 | WP_002504702.1 | type I restriction endonuclease subunit R | - |
| RGC89_RS00450 (RGC89_00450) | - | 93085..94359 (-) | 1275 | WP_002504701.1 | restriction endonuclease subunit S | - |
| RGC89_RS00455 (RGC89_00455) | - | 94349..95863 (-) | 1515 | WP_309478141.1 | class I SAM-dependent DNA methyltransferase | - |
| RGC89_RS00460 (RGC89_00460) | - | 96054..96866 (+) | 813 | WP_002504699.1 | abortive infection system antitoxin AbiGi family protein | - |
Sequence
Protein
Download Length: 448 a.a. Molecular weight: 52138.19 Da Isoelectric Point: 10.1760
>NTDB_id=875709 RGC89_RS00280 WP_000816499.1 61714..63060(-) (ccrA) [Staphylococcus epidermidis strain AR4072]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA
Nucleotide
Download Length: 1347 bp
>NTDB_id=875709 RGC89_RS00280 WP_000816499.1 61714..63060(-) (ccrA) [Staphylococcus epidermidis strain AR4072]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus COL |
78.174 |
100 |
0.783 |
| ccrA | Staphylococcus aureus N315 |
72.383 |
100 |
0.725 |