NTDB

Overview

Name	micA	Type	Regulator
Locus tag	RDV54_RS03185	Genome accession	NZ_CP133471
Coordinates	649269..649976 (-)	Length	235 a.a.
NCBI ID	WP_000722072.1	Uniprot ID	A0A3R9LLL2
Organism	Streptococcus mitis strain LMG 14557
Function	repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 644269..654976

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RDV54_RS03155 (RDV54_03155)	-	645422..645769 (+)	348	WP_000434630.1	thiol reductase thioredoxin	-
RDV54_RS03160 (RDV54_03160)	-	645807..646484 (-)	678	WP_000566125.1	potassium channel family protein	-
RDV54_RS03165 (RDV54_03165)	-	646527..646781 (-)	255	WP_004239453.1	type II toxin-antitoxin system RelE family toxin	-
RDV54_RS03170 (RDV54_03170)	relB	646783..647025 (-)	243	WP_000208079.1	type II toxin-antitoxin system RelB family antitoxin	-
RDV54_RS03175 (RDV54_03175)	vicX	647116..647925 (-)	810	WP_000004960.1	MBL fold metallo-hydrolase	Regulator
RDV54_RS03180 (RDV54_03180)	micB	647918..649276 (-)	1359	WP_000571163.1	cell wall metabolism sensor histidine kinase VicK	Regulator
RDV54_RS03185 (RDV54_03185)	micA	649269..649976 (-)	708	WP_000722072.1	response regulator YycF	Regulator
RDV54_RS03190 (RDV54_03190)	mutY	650032..651207 (-)	1176	WP_000886130.1	A/G-specific adenine glycosylase	-
RDV54_RS03195 (RDV54_03195)	pta	651396..652370 (-)	975	WP_000451571.1	phosphate acetyltransferase	-
RDV54_RS03200 (RDV54_03200)	-	652414..653310 (-)	897	WP_001209983.1	RluA family pseudouridine synthase	-
RDV54_RS03205 (RDV54_03205)	-	653307..654125 (-)	819	WP_000799056.1	NAD kinase	-
RDV54_RS03210 (RDV54_03210)	-	654109..654780 (-)	672	WP_000171692.1	GTP pyrophosphokinase	-

Sequence

Protein

Download Length: 235 a.a. Molecular weight: 27107.90 Da Isoelectric Point: 4.6177

                                >NTDB_id=874474 RDV54_RS03185 WP_000722072.1 649269..649976(-) (micA) [Streptococcus mitis strain LMG 14557]

MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA

KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDLVSVDNQESDEKKTQPLQIGDLEIVPDAYVAKKYGEELDL

THREFELLYHLASHIGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

Download Length: 708 bp

                                >NTDB_id=874474 RDV54_RS03185 WP_000722072.1 649269..649976(-) (micA) [Streptococcus mitis strain LMG 14557]

ATGAAAAAAATATTAATTGTAGATGATGAAAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA

GGTTGTAACTGCTTTTAATGGTCGTGAAGCACTAGAACAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA

TGCTTCCCGAAATTGATGGTTTAGAAGTTGCAAAGACTATTCGTAAGACGAGTAGTGTTCCTATTATCATGCTGTCAGCT

AAAGACAGCGAATTTGATAAGGTTATTGGTTTGGAGCTTGGAGCGGATGACTATGTGACAAAACCCTTCTCAAATCGTGA

GTTGCAGGCGCGTGTTAAAGCTCTTCTTCGTCGTACGGACTTGGTTTCTGTAGATAATCAAGAGTCAGATGAAAAGAAAA

CCCAACCTTTGCAAATTGGGGACTTGGAGATTGTACCAGATGCCTATGTGGCTAAAAAATATGGTGAAGAACTAGACTTG

ACCCACCGTGAATTTGAACTTTTGTACCACTTGGCTTCTCATATTGGTCAAGTGATTACCCGTGAACACTTGCTTGAAAC

GGTCTGGGGGTATGATTATTTCGGAGATGTTCGGACTGTTGACGTAACTATCAGACGTTTGCGTGAGAAGATTGAAGATA

CACCTAGTCGTCCAGAGTATATCCTAACACGTCGTGGTGTTGGTTATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(155-230)

Response regulator receiver domain (Response_reg)

(4-112)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A3R9LLL2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
micA	Streptococcus pneumoniae Cp1015	94.017	99.574	0.936
vicR	Streptococcus mutans UA159	77.447	100	0.774
covR	Streptococcus salivarius strain HSISS4	44.589	98.298	0.438
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.723	98.298	0.43
scnR	Streptococcus mutans UA159	38.034	99.574	0.379

Detailed information NTG0874474