Detailed information NTG0868548

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RAM34_RS06885
• Genome accession: NZ_CP132365
• Coordinates: 1397594..1398637 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UNC_SA54
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1392594..1403637

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RAM34_RS06855 (RAM34_06850)	-	1393015..1394271 (-)	1257	WP_001795108.1	aminopeptidase	-
RAM34_RS06860 (RAM34_06855)	-	1394274..1394474 (-)	201	WP_000180460.1	DUF1128 family protein	-
RAM34_RS06865 (RAM34_06860)	-	1394621..1395085 (+)	465	WP_306176504.1	low molecular weight protein-tyrosine-phosphatase	-
RAM34_RS06870 (RAM34_06865)	-	1395092..1395367 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
RAM34_RS06875 (RAM34_06870)	-	1395645..1396862 (+)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RAM34_RS06880 (RAM34_06875)	vraR	1396975..1397604 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RAM34_RS06885 (RAM34_06880)	vraS	1397594..1398637 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RAM34_RS06890 (RAM34_06885)	liaF	1398634..1399335 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RAM34_RS06895 (RAM34_06890)	-	1399350..1399736 (-)	387	WP_001110179.1	hypothetical protein	-
RAM34_RS06900 (RAM34_06895)	map	1399953..1400711 (-)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RAM34_RS06905 (RAM34_06900)	-	1401242..1402228 (+)	987	WP_000999717.1	aromatic acid exporter family protein	-
RAM34_RS06910 (RAM34_06905)	-	1402659..1403072 (-)	414	WP_001557448.1	hypothetical protein	-
RAM34_RS06915 (RAM34_06910)	-	1403101..1403211 (-)	111	WP_001790257.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=868548 RAM34_RS06885 WP_001017131.1 1397594..1398637(-) (vraS) [Staphylococcus aureus strain UNC_SA54]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=868548 RAM34_RS06885 WP_001017131.1 1397594..1398637(-) (vraS) [Staphylococcus aureus strain UNC_SA54]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1