Detailed information NTG0868485

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: RAM28_RS06615
• Genome accession: NZ_CP132362
• Coordinates: 1336573..1337616 (+)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain UNC_SA55
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1331573..1342616

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RAM28_RS06585 (RAM28_06570)	-	1331999..1332109 (+)	111	WP_001790257.1	hypothetical protein	-
RAM28_RS06590 (RAM28_06575)	-	1332138..1332551 (+)	414	WP_001557448.1	hypothetical protein	-
RAM28_RS06595 (RAM28_06580)	-	1332982..1333968 (-)	987	WP_000999717.1	aromatic acid exporter family protein	-
RAM28_RS06600 (RAM28_06585)	map	1334499..1335257 (+)	759	WP_000636142.1	type I methionyl aminopeptidase	-
RAM28_RS06605 (RAM28_06590)	-	1335474..1335860 (+)	387	WP_001110179.1	hypothetical protein	-
RAM28_RS06610 (RAM28_06595)	liaF	1335875..1336576 (+)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
RAM28_RS06615 (RAM28_06600)	vraS	1336573..1337616 (+)	1044	WP_001017131.1	sensor histidine kinase	Regulator
RAM28_RS06620 (RAM28_06605)	vraR	1337606..1338235 (+)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
RAM28_RS06625 (RAM28_06610)	-	1338348..1339565 (-)	1218	WP_000037075.1	YihY/virulence factor BrkB family protein	-
RAM28_RS06630 (RAM28_06615)	-	1339843..1340118 (-)	276	WP_000428172.1	YtxH domain-containing protein	-
RAM28_RS06635 (RAM28_06620)	-	1340125..1340589 (-)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
RAM28_RS06640 (RAM28_06625)	-	1340736..1340936 (+)	201	WP_000180460.1	DUF1128 family protein	-
RAM28_RS06645 (RAM28_06630)	-	1340939..1342195 (+)	1257	WP_001795108.1	aminopeptidase	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=868485 RAM28_RS06615 WP_001017131.1 1336573..1337616(+) (vraS) [Staphylococcus aureus strain UNC_SA55]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=868485 RAM28_RS06615 WP_001017131.1 1336573..1337616(+) (vraS) [Staphylococcus aureus strain UNC_SA55]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTATTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTACTCGCATACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAGTTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCTCGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTTTCTGCTATCAAAGAAACGAAGTTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGTTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGATAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1