Detailed information
Bioinformatically predicted
Overview
| Name | ccrA | Type | Machinery gene |
| Locus tag | RAM28_RS02055 | Genome accession | NZ_CP132362 |
| Coordinates | 441369..442718 (+) | Length | 449 a.a. |
| NCBI ID | WP_000815646.1 | Uniprot ID | Q9XB96 |
| Organism | Staphylococcus aureus strain UNC_SA55 | ||
| Function | promote SCCmec transfer (predicted from homology) Homologous recombination |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 405864..449589 | 441369..442718 | within | 0 |
| SCCmec | 441369..462734 | 441369..442718 | within | 0 |
Gene organization within MGE regions
Location: 405864..462734
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| RAM28_RS01895 (RAM28_01895) | - | 405864..409016 (-) | 3153 | WP_000080564.1 | ATP-binding protein | - |
| RAM28_RS01900 (RAM28_01900) | - | 409283..409885 (-) | 603 | WP_000908956.1 | hypothetical protein | - |
| RAM28_RS01905 (RAM28_01905) | - | 410093..410389 (-) | 297 | WP_000201644.1 | TfoX/Sxy family protein | - |
| RAM28_RS01910 (RAM28_01910) | - | 410438..410641 (-) | 204 | WP_000389759.1 | DUF6007 family protein | - |
| RAM28_RS01915 (RAM28_01915) | - | 410950..411936 (+) | 987 | WP_000662022.1 | tRNA-dihydrouridine synthase | - |
| RAM28_RS01920 | - | 412122..412336 (+) | 215 | Protein_377 | universal stress protein | - |
| RAM28_RS01925 (RAM28_01925) | sqr | 412603..413796 (-) | 1194 | WP_001033018.1 | type II sulfide:quinone oxidoreductase Sqr | - |
| RAM28_RS01930 (RAM28_01930) | cstB | 413815..415149 (-) | 1335 | WP_000465472.1 | persulfide dioxygenase-sulfurtransferase CstB | - |
| RAM28_RS01935 (RAM28_01935) | cstA | 415180..416244 (-) | 1065 | WP_000816133.1 | persulfide response sulfurtransferase CstA | - |
| RAM28_RS01940 (RAM28_01940) | cstR | 416381..416641 (+) | 261 | WP_001105088.1 | persulfide-sensing transcriptional repressor CstR | - |
| RAM28_RS01945 (RAM28_01945) | - | 416641..417396 (+) | 756 | WP_000355845.1 | sulfite exporter TauE/SafE family protein | - |
| RAM28_RS01950 (RAM28_01950) | - | 417494..417582 (+) | 89 | Protein_383 | hypothetical protein | - |
| RAM28_RS01955 (RAM28_01955) | - | 417887..418242 (+) | 356 | Protein_384 | tRNA-dihydrouridine synthase | - |
| RAM28_RS01960 (RAM28_01960) | - | 418340..420085 (-) | 1746 | WP_000700190.1 | DUF6119 family protein | - |
| RAM28_RS01965 (RAM28_01965) | - | 420232..420324 (-) | 93 | WP_001790000.1 | hypothetical protein | - |
| RAM28_RS01970 (RAM28_01970) | - | 420288..420422 (+) | 135 | WP_001790628.1 | hypothetical protein | - |
| RAM28_RS01975 (RAM28_01975) | - | 420672..422180 (-) | 1509 | WP_001001347.1 | protein kinase domain-containing protein | - |
| RAM28_RS01980 (RAM28_01980) | - | 422295..422921 (+) | 627 | WP_001176969.1 | hypothetical protein | - |
| RAM28_RS01985 (RAM28_01985) | - | 424040..424936 (+) | 897 | WP_000411461.1 | DUF927 domain-containing protein | - |
| RAM28_RS01990 (RAM28_01990) | - | 424946..425815 (+) | 870 | WP_000626133.1 | hypothetical protein | - |
| RAM28_RS01995 (RAM28_01995) | - | 426360..426917 (-) | 558 | WP_001193482.1 | K(+)-transporting ATPase subunit C | - |
| RAM28_RS02000 (RAM28_02000) | - | 426933..428954 (-) | 2022 | WP_000852430.1 | K(+)-transporting ATPase subunit B | - |
| RAM28_RS02005 (RAM28_02005) | kdpA | 428973..430649 (-) | 1677 | WP_000029430.1 | potassium-transporting ATPase subunit KdpA | - |
| RAM28_RS02010 | kdpF | 430670..430750 (-) | 81 | WP_000631574.1 | K(+)-transporting ATPase subunit F | - |
| RAM28_RS02015 (RAM28_02010) | - | 430917..433586 (+) | 2670 | WP_000446429.1 | sensor histidine kinase KdpD | - |
| RAM28_RS02020 (RAM28_02015) | - | 433561..434256 (+) | 696 | WP_000858967.1 | response regulator transcription factor | - |
| RAM28_RS02025 (RAM28_02020) | - | 434969..435904 (+) | 936 | Protein_398 | YfcC family protein | - |
| RAM28_RS02030 (RAM28_02025) | - | 436111..436245 (-) | 135 | WP_001792216.1 | hypothetical protein | - |
| RAM28_RS02035 (RAM28_02030) | - | 436415..437556 (+) | 1142 | Protein_400 | IS3-like element ISSau4 family transposase | - |
| RAM28_RS02040 (RAM28_02035) | - | 437807..438853 (+) | 1047 | WP_001060127.1 | hypothetical protein | - |
| RAM28_RS02045 (RAM28_02040) | ssb | 439046..439342 (+) | 297 | WP_000273824.1 | cassette chromosome ssDNA-binding protein | - |
| RAM28_RS02050 (RAM28_02045) | cch1 | 439342..441135 (+) | 1794 | WP_306216543.1 | cassette chromosome replicative helicase | - |
| RAM28_RS02055 (RAM28_02050) | ccrA | 441369..442718 (+) | 1350 | WP_000815646.1 | cassette chromosome recombinase CcrA | Machinery gene |
| RAM28_RS02060 (RAM28_02055) | ccrB | 442740..444368 (+) | 1629 | WP_001186602.1 | cassette chromosome recombinase CcrB | Machinery gene |
| RAM28_RS02065 (RAM28_02060) | - | 444886..445236 (+) | 351 | WP_000859155.1 | SAUGI family uracil-DNA glycosylase inhibitor | - |
| RAM28_RS02070 (RAM28_02065) | - | 445323..445634 (+) | 312 | WP_000700853.1 | DUF960 family protein | - |
| RAM28_RS02075 (RAM28_02070) | - | 445652..446158 (+) | 507 | WP_001092169.1 | DUF1643 domain-containing protein | - |
| RAM28_RS02080 (RAM28_02075) | - | 446179..446496 (+) | 318 | WP_000659050.1 | JAB domain-containing protein | - |
| RAM28_RS02085 (RAM28_02080) | - | 446615..447700 (+) | 1086 | WP_000868132.1 | tyrosine-type recombinase/integrase | - |
| RAM28_RS02090 (RAM28_02085) | - | 447697..449589 (+) | 1893 | WP_001557544.1 | site-specific integrase | - |
| RAM28_RS02095 (RAM28_02090) | - | 449596..449973 (+) | 378 | WP_000361059.1 | DUF6262 family protein | - |
| RAM28_RS02100 (RAM28_02095) | - | 450124..450906 (+) | 783 | WP_000067268.1 | aminoglycoside nucleotidyltransferase ANT(9)-Ia | - |
| RAM28_RS02105 (RAM28_02100) | erm(A) | 451032..451763 (-) | 732 | WP_001072201.1 | 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(A) | - |
| RAM28_RS14510 | - | 451846..451905 (-) | 60 | WP_010959190.1 | erythromycin resistance leader peptide | - |
| RAM28_RS02110 (RAM28_02105) | - | 452297..452959 (+) | 663 | WP_001092058.1 | class I SAM-dependent methyltransferase | - |
| RAM28_RS02115 (RAM28_02110) | - | 453304..453942 (-) | 639 | Protein_417 | sulfite exporter TauE/SafE family protein | - |
| RAM28_RS02120 (RAM28_02115) | cstR | 453942..454202 (-) | 261 | WP_000220507.1 | persulfide-sensing transcriptional repressor CstR | - |
| RAM28_RS02125 (RAM28_02120) | - | 454338..455402 (+) | 1065 | WP_000438836.1 | DsrE/DsrF/DrsH-like family protein | - |
| RAM28_RS02130 (RAM28_02125) | cstB | 455435..456769 (+) | 1335 | Protein_420 | persulfide dioxygenase-sulfurtransferase CstB | - |
| RAM28_RS02135 (RAM28_02130) | - | 456883..458013 (-) | 1131 | WP_010922808.1 | ROK family transcriptional regulator | - |
| RAM28_RS02140 (RAM28_02135) | psm-mec | 458347..458415 (+) | 69 | WP_014532405.1 | phenol-soluble modulin PSM-mec | - |
| RAM28_RS02145 (RAM28_02140) | mecI | 458500..458871 (-) | 372 | WP_000369214.1 | mecA-type methicillin resistance repressor MecI | - |
| RAM28_RS02150 (RAM28_02145) | mecR1 | 458871..460628 (-) | 1758 | WP_000952923.1 | beta-lactam sensor/signal transducer MecR1 | - |
| RAM28_RS02155 (RAM28_02150) | mecA | 460725..462734 (+) | 2010 | WP_001801873.1 | PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 52607.20 Da Isoelectric Point: 9.9585
>NTDB_id=868474 RAM28_RS02055 WP_000815646.1 441369..442718(+) (ccrA) [Staphylococcus aureus strain UNC_SA55]
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
MKQVIGYLRQSTMKQQSLAAQKQAIEAIAEKHHIQHINFYSDKQSGRKDNRSGYRQMTQLIQQGQCDILCCYRLNRLHRN
LKNALKLIKLCQTYHVHILSVHDGYFDMDQAFDRFKLNIFISLAELESDNIGEQVRNGLQEKAKQGRLITTHAPFGYEYH
NGAFIINQNESPTVKAVFNYYIKGHGYKKIAQLLEEDNTYINRQPYQVRNIIINPNYCGRVNNQYGQFDNMFPSIVSTSI
YEQAQRLRSQKQIKQTSSDNQLKQKIKCPCCNTTLTNMTVRKKNHTLRYYVCPKNMNASRFVCDFKGINAQTLEDKVLEV
CKDFYQNQRIYTKIKGAIDKRIKRQRNIEKHHTLTQEQLIEKLAQGIIDAETFREQTQSLRQQPQRTTSINGHQIQHTIQ
NIIQKRFTLNILYPYIETIHITKDKNLIGIYFKNEPLNIVNQTMQSSIA
Nucleotide
Download Length: 1350 bp
>NTDB_id=868474 RAM28_RS02055 WP_000815646.1 441369..442718(+) (ccrA) [Staphylococcus aureus strain UNC_SA55]
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
ATGAAACAAGTCATAGGCTATTTACGTCAAAGTACGATGAAACAACAATCTCTTGCAGCACAGAAACAGGCTATCGAAGC
AATAGCCGAAAAACATCATATTCAACATATCAACTTTTATAGCGACAAACAATCAGGACGCAAAGATAATCGTAGTGGGT
ATCGACAAATGACGCAATTAATTCAACAAGGGCAATGTGACATATTATGTTGTTATCGTCTTAATAGATTACATCGTAAT
CTGAAAAATGCATTAAAACTCATCAAATTATGTCAAACATACCATGTTCATATCTTAAGCGTACACGATGGTTACTTTGA
TATGGATCAAGCTTTCGACCGATTCAAGCTTAATATTTTTATCAGCTTGGCCGAACTTGAATCAGATAACATTGGAGAAC
AAGTCAGAAATGGGCTTCAAGAAAAAGCAAAGCAAGGTCGATTGATTACAACCCATGCGCCCTTTGGTTACGAATATCAC
AACGGAGCATTCATCATCAATCAAAATGAGTCACCAACGGTAAAGGCTGTATTCAATTATTACATTAAAGGTCATGGTTA
TAAGAAAATTGCACAGTTATTAGAAGAAGATAACACGTATATCAATCGACAACCCTATCAAGTTCGTAACATTATCATCA
ATCCTAATTATTGTGGTCGTGTCAACAATCAATATGGCCAATTCGACAATATGTTTCCTTCTATTGTTTCCACAAGTATA
TATGAGCAAGCGCAGAGACTTCGATCGCAAAAACAAATCAAACAGACATCTTCGGATAACCAACTAAAACAAAAAATCAA
ATGCCCATGTTGTAATACAACACTTACGAATATGACCGTTAGAAAAAAGAATCATACATTACGTTACTACGTCTGTCCTA
AAAACATGAATGCTTCTCGCTTTGTCTGTGATTTTAAAGGCATCAATGCACAAACACTTGAAGATAAAGTATTAGAAGTG
TGCAAAGACTTTTATCAAAATCAACGCATCTACACAAAAATTAAAGGTGCGATTGACAAACGCATCAAAAGACAAAGAAA
CATAGAAAAACATCACACATTGACTCAAGAACAACTGATAGAAAAGTTGGCACAAGGCATCATCGATGCAGAAACGTTCA
GAGAACAAACGCAATCATTACGTCAACAACCGCAACGCACTACATCTATCAATGGACATCAAATACAACACACCATTCAA
AATATTATTCAAAAACGTTTCACGTTAAACATATTGTACCCCTATATTGAAACCATTCACATTACGAAAGATAAAAATCT
TATAGGAATCTATTTCAAAAATGAACCACTCAATATCGTCAATCAAACCATGCAATCATCGATTGCATAA
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ccrA | Staphylococcus aureus N315 |
100 |
100 |
1 |
| ccrA | Staphylococcus aureus COL |
74.833 |
100 |
0.748 |