Detailed information NTG0086735

Bioinformatically predicted

Overview

• Name: clpC
• Type: Regulator
• Locus tag: K6J89_RS00575
• Genome accession: NZ_AP024621
• Coordinates: 103162..105594 (+)
• Length: 810 a.a.
• NCBI ID: WP_003235011.1
• Uniprot ID: P37571
• Organism: Bacillus subtilis strain BEST3095
• Function: degradation of ComK; degradation of DegU (predicted from homology) Competence regulation

Genomic Context

Location: 98162..110594

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
K6J89_RS00560 (BsBEST3095_00830)	ctsR	101039..101503 (+)	465	WP_003225724.1	transcriptional regulator CtsR	-
K6J89_RS00565 (BsBEST3095_00840)	mcsA	101517..102074 (+)	558	WP_009966297.1	protein-arginine kinase activator protein McsA	-
K6J89_RS00570 (BsBEST3095_00850)	mcsB	102074..103165 (+)	1092	WP_003235007.1	protein arginine kinase	-
K6J89_RS00575 (BsBEST3095_00860)	clpC	103162..105594 (+)	2433	WP_003235011.1	ATP-dependent protease ATP-binding subunit ClpC	Regulator
K6J89_RS00580 (BsBEST3095_00870)	radA	105686..107062 (+)	1377	WP_004399687.1	DNA repair protein RadA	Machinery gene
K6J89_RS00585 (BsBEST3095_00880)	disA	107066..108148 (+)	1083	WP_003225736.1	DNA integrity scanning diadenylate cyclase DisA	-
K6J89_RS00590 (BsBEST3095_00890)	yacL	108264..109364 (+)	1101	WP_003235014.1	PIN/TRAM domain-containing protein	-
K6J89_RS00595 (BsBEST3095_00900)	ispD	109379..110077 (+)	699	WP_003235019.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
K6J89_RS00600 (BsBEST3095_00910)	ispF	110070..110546 (+)	477	WP_003225745.1	2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase	-

Sequence

Protein

• Length: 810 a.a.
• Molecular weight: 90118.60 Da
• Isoelectric Point: 6.0257

>NTDB_id=86735 K6J89_RS00575 WP_003235011.1 103162..105594(+) (clpC) [Bacillus subtilis strain BEST3095]
MMFGRFTERAQKVLALAQEEALRLGHNNIGTEHILLGLVREGEGIAAKALQALGLGSEKIQKEVESLIGRGQEMSQTIHY
TPRAKKVIELSMDEARKLGHSYVGTEHILLGLIREGEGVAARVLNNLGVSLNKARQQVLQLLGSNETGSSAAGTNSNANT
PTLDSLARDLTAIAKEDSLDPVIGRSKEIQRVIEVLSRRTKNNPVLIGEPGVGKTAIAEGLAQQIINNEVPEILRDKRVM
TLDMGTVVAGTKYRGEFEDRLKKVMDEIRQAGNIILFIDELHTLIGAGGAEGAIDASNILKPSLARGELQCIGATTLDEY
RKYIEKDAALERRFQPIQVDQPSVDESIQILQGLRDRYEAHHRVSITDDAIEAAVKLSDRYISDRFLPDKAIDLIDEAGS
KVRLRSFTTPPNLKELEQKLDEVRKEKDAAVQSQEFEKAASLRDTEQRLREQVEDTKKSWKEKQGQENSEVTVDDIAMVV
SSWTGVPVSKIAQTETDKLLNMENILHSRVIGQDEAVVAVAKAVRRARAGLKDPKRPIGSFIFLGPTGVGKTELARALAE
SIFGDEESMIRIDMSEYMEKHSTSRLVGSPPGYVGYDEGGQLTEKVRRKPYSVVLLDEIEKAHPDVFNILLQVLEDGRLT
DSKGRTVDFRNTILIMTSNVGASELKRNKYVGFNVQDETQNHKDMKDKVMGELKRAFRPEFINRIDEIIVFHSLEKKHLT
EIVSLMSDQLTKRLKEQDLSIELTDAAKAKVAEEGVDLEYGARPLRRAIQKHVEDRLSEELLRGNIHKGQHIVLDVEDGE
FVVKTTAKTN

Nucleotide

• Length: 2433 bp

>NTDB_id=86735 K6J89_RS00575 WP_003235011.1 103162..105594(+) (clpC) [Bacillus subtilis strain BEST3095]
ATGATGTTTGGAAGATTTACAGAACGAGCTCAAAAAGTACTGGCGCTAGCACAGGAAGAAGCACTTCGGTTAGGTCATAA
TAACATTGGCACTGAGCATATTTTATTAGGACTGGTAAGAGAAGGAGAGGGCATTGCTGCTAAAGCTCTTCAAGCGCTTG
GACTCGGTTCAGAAAAAATTCAGAAAGAAGTAGAAAGTTTGATCGGGCGCGGGCAGGAAATGTCTCAAACGATTCATTAT
ACTCCTAGAGCTAAAAAAGTCATTGAGCTTTCAATGGATGAGGCAAGAAAACTCGGTCATTCTTATGTGGGAACAGAACA
TATTCTTCTTGGTCTGATTCGTGAAGGAGAAGGTGTTGCTGCGAGAGTTCTGAATAATCTCGGTGTCAGCTTAAATAAAG
CAAGACAGCAGGTGCTCCAGCTTCTAGGAAGTAATGAAACAGGATCATCAGCGGCAGGAACAAACAGCAATGCGAATACG
CCTACGCTTGACAGCTTGGCAAGAGACTTAACTGCTATTGCGAAGGAAGACAGCCTTGACCCTGTAATCGGCAGAAGCAA
GGAGATCCAGCGTGTCATTGAAGTGTTAAGCCGCAGAACGAAAAACAACCCTGTTCTCATTGGGGAACCAGGTGTAGGTA
AAACGGCTATCGCAGAAGGTTTGGCACAGCAAATTATCAATAATGAAGTACCCGAAATTTTGCGTGATAAACGTGTGATG
ACATTAGACATGGGAACAGTTGTTGCCGGCACAAAATACCGCGGAGAATTTGAGGATCGCCTGAAGAAGGTCATGGATGA
AATTCGCCAGGCAGGAAATATCATTCTATTCATCGATGAGCTCCATACATTAATCGGGGCAGGCGGAGCAGAAGGTGCTA
TTGATGCATCTAATATTTTAAAACCTTCACTTGCTCGTGGCGAACTCCAATGTATTGGTGCAACGACTCTTGATGAGTAC
CGTAAATATATTGAAAAAGATGCAGCACTGGAACGCCGTTTTCAGCCGATTCAGGTTGATCAGCCATCTGTAGATGAAAG
TATTCAAATTTTACAAGGTCTGCGTGACAGATACGAAGCCCACCACCGCGTTTCTATCACTGATGATGCCATTGAAGCTG
CGGTTAAGCTTTCTGACAGATATATTTCTGACCGCTTCCTTCCGGATAAAGCAATTGACTTGATCGATGAAGCGGGTTCA
AAGGTGAGACTGCGCTCATTTACAACGCCTCCTAACTTAAAAGAGCTTGAGCAGAAGCTTGATGAGGTTCGTAAAGAGAA
GGATGCGGCAGTGCAAAGCCAAGAGTTTGAAAAAGCTGCTTCCTTGCGTGATACTGAACAACGCCTGCGCGAGCAAGTAG
AGGATACGAAGAAATCATGGAAAGAGAAGCAAGGGCAGGAAAACTCAGAGGTTACTGTGGATGATATTGCGATGGTTGTA
TCCAGCTGGACCGGTGTGCCTGTATCTAAAATCGCCCAAACTGAAACTGATAAGCTTCTCAATATGGAAAACATTCTTCA
CTCCCGTGTCATCGGCCAGGATGAAGCAGTTGTAGCGGTTGCAAAAGCCGTCAGACGTGCAAGAGCAGGATTGAAAGATC
CTAAACGCCCAATCGGCTCATTCATTTTCTTAGGCCCTACAGGTGTAGGTAAAACAGAACTTGCACGAGCACTTGCTGAA
TCCATTTTTGGCGATGAAGAATCCATGATCAGAATTGATATGTCTGAATACATGGAAAAACATTCAACTTCAAGACTTGT
TGGTTCACCTCCGGGTTATGTGGGATATGATGAAGGCGGTCAATTGACAGAGAAAGTCAGAAGAAAACCTTACTCTGTCG
TGCTTCTTGATGAGATCGAGAAAGCGCACCCTGATGTCTTCAATATCCTTCTGCAAGTTCTTGAAGACGGACGATTGACT
GATTCTAAAGGACGCACAGTCGATTTCCGCAATACCATTCTGATCATGACATCAAACGTCGGAGCAAGTGAGCTAAAACG
CAATAAATATGTCGGCTTTAACGTTCAGGATGAAACTCAAAATCATAAAGACATGAAAGATAAAGTGATGGGTGAATTAA
AACGAGCGTTCAGACCTGAGTTCATCAACCGTATTGATGAAATCATTGTCTTCCATTCACTTGAGAAAAAACATCTCACT
GAGATTGTGTCATTAATGTCTGATCAATTAACGAAACGCCTGAAAGAACAAGATCTTTCTATCGAATTGACAGATGCTGC
AAAAGCGAAAGTCGCGGAAGAGGGCGTTGACCTGGAATACGGTGCCCGTCCGTTAAGAAGAGCGATCCAAAAACATGTCG
AGGATCGTTTATCTGAAGAACTCCTCAGAGGAAATATTCATAAAGGACAGCATATTGTTCTTGATGTAGAAGATGGCGAA
TTTGTCGTAAAAACGACTGCTAAAACGAATTAA

Domains

Predicted by InterproScan.

• Clp amino terminal domain, pathogenicity island component (Clp_N) (93-143)

• Clp amino terminal domain, pathogenicity island component (Clp_N) (17-69)

• AAA lid domain (AAA_lid_9) (343-444)

• ATPase family associated with various cellular activities (AAA) (AAA) (205-317)

• C-terminal, D2-small domain, of ClpB protein (ClpB_D2-small) (714-793)

• AAA domain (Cdc48 subfamily) (AAA_2) (536-708)

3D structure

• PDB: 2K77
• PDB: 2Y1Q
• PDB: 2Y1R
• PDB: 3J3R
• PDB: 3J3S
• PDB: 3J3T
• PDB: 3J3U
• PDB: 3PXG
• PDB: 3PXI
• PDB: 5HBN
• PDB: 7ABR
• PDB: 8B3S
• PDB: 8OTK

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
clpC	Bacillus subtilis subsp. subtilis str. 168	100	100	1
clpC	Lactococcus lactis subsp. lactis strain DGCC12653	50.499	99.012	0.5
clpC	Streptococcus thermophilus LMD-9	46.65	100	0.473
clpC	Streptococcus thermophilus LMG 18311	46.407	100	0.47
clpC	Streptococcus pneumoniae Rx1	45.241	99.877	0.452
clpC	Streptococcus pneumoniae D39	45.241	99.877	0.452
clpC	Streptococcus pneumoniae TIGR4	45.117	99.877	0.451
clpC	Streptococcus mutans UA159	43.584	100	0.444
clpE	Streptococcus mutans UA159	53.313	80.123	0.427
clpC	Lactococcus lactis subsp. cremoris KW2	48.664	87.778	0.427
clpE	Streptococcus pneumoniae TIGR4	52.388	80.123	0.42
clpE	Streptococcus pneumoniae Rx1	52.388	80.123	0.42
clpE	Streptococcus pneumoniae D39	52.388	80.123	0.42
clpE	Streptococcus pneumoniae R6	52.388	80.123	0.42