Detailed information NTG0864081

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: Q7624_RS10800
• Genome accession: NZ_CP131709
• Coordinates: 2085547..2086299 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 2016S11-245
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2080547..2091299

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7624_RS10775 (Q7624_10735)	-	2080926..2083478 (+)	2553	WP_000834680.1	YfhO family protein	-
Q7624_RS10780 (Q7624_10740)	-	2083508..2084655 (-)	1148	Protein_2085	YhgE/Pip family protein	-
Q7624_RS10785 (Q7624_10745)	-	2084762..2085304 (+)	543	WP_001158266.1	TetR/AcrR family transcriptional regulator	-
Q7624_RS10800 (Q7624_10760)	comE	2085547..2086299 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
Q7624_RS10805 (Q7624_10765)	comD/comD1	2086296..2087621 (-)	1326	WP_000362880.1	competence system sensor histidine kinase ComD	Regulator
Q7624_RS10810 (Q7624_10770)	comC/comC1	2087642..2087767 (-)	126	WP_000799689.1	competence-stimulating peptide ComC	Regulator
Q7624_RS10820 (Q7624_10780)	rlmH	2088049..2088528 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
Q7624_RS10825 (Q7624_10785)	htrA	2088711..2089892 (+)	1182	WP_000681597.1	trypsin-like peptidase domain-containing protein	Regulator
Q7624_RS10830 (Q7624_10790)	spo0J	2089950..2090708 (+)	759	WP_000410376.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=864081 Q7624_RS10800 WP_000866065.1 2085547..2086299(-) (comE) [Streptococcus pneumoniae strain 2016S11-245]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=864081 Q7624_RS10800 WP_000866065.1 2085547..2086299(-) (comE) [Streptococcus pneumoniae strain 2016S11-245]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTCTCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408