NTDB

Overview

Name	comEA/celA/cilE	Type	Machinery gene
Locus tag	Q7624_RS05950	Genome accession	NZ_CP131709
Coordinates	1170329..1170979 (-)	Length	216 a.a.
NCBI ID	WP_000387328.1	Uniprot ID	A0A4N9N7Z7
Organism	Streptococcus pneumoniae strain 2016S11-245
Function	dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1165329..1175979

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q7624_RS05930 (Q7624_05910)	-	1165934..1167115 (-)	1182	WP_000655951.1	membrane protein	-
Q7624_RS05935 (Q7624_05915)	-	1167119..1167706 (-)	588	WP_000939884.1	ABC transporter ATP-binding protein	-
Q7624_RS05940 (Q7624_05920)	-	1167739..1167963 (-)	225	WP_000583432.1	hypothetical protein	-
Q7624_RS05945 (Q7624_05925)	comEC/celB	1168105..1170345 (-)	2241	WP_000942392.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
Q7624_RS05950 (Q7624_05930)	comEA/celA/cilE	1170329..1170979 (-)	651	WP_000387328.1	ComEA family DNA-binding protein	Machinery gene
Q7624_RS05955 (Q7624_05935)	-	1171047..1171616 (-)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
Q7624_RS05960 (Q7624_05940)	ald	1171793..1172904 (+)	1112	Protein_1180	alanine dehydrogenase	-
Q7624_RS05965 (Q7624_05945)	-	1173205..1173531 (-)	327	Protein_1181	TfoX/Sxy family protein	-
Q7624_RS05970 (Q7624_05950)	-	1173534..1174034 (-)	501	WP_000566986.1	GNAT family N-acetyltransferase	-
Q7624_RS05975 (Q7624_05955)	-	1174227..1175195 (-)	969	WP_000658198.1	PhoH family protein	-
Q7624_RS05980 (Q7624_05960)	-	1175281..1175496 (-)	216	WP_001232081.1	YozE family protein	-

Sequence

Protein

Download Length: 216 a.a. Molecular weight: 23230.59 Da Isoelectric Point: 5.0667

                                >NTDB_id=864033 Q7624_RS05950 WP_000387328.1 1170329..1170979(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 2016S11-245]

MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEEEVNKEEKEEPLEQDLITVDVKG

AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA

SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

Download Length: 651 bp

                                >NTDB_id=864033 Q7624_RS05950 WP_000387328.1 1170329..1170979(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 2016S11-245]

ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT

TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT

TGGTATCCGAAGAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT

GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC

AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG

AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC

AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG

CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA

CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A4N9N7Z7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	89.815	100	0.898
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366

Detailed information NTG0864033