Detailed information    

insolico Bioinformatically predicted

Overview

Name   ccrA   Type   Machinery gene
Locus tag   Q7640_RS00360 Genome accession   NZ_CP131659
Coordinates   83731..85077 (-) Length   448 a.a.
NCBI ID   WP_000816499.1    Uniprot ID   Q9R3W9
Organism   Staphylococcus aureus strain 2010N21-057     
Function   promote SCCmec transfer (predicted from homology)   
Homologous recombination

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
SCCmec 40375..85077 83731..85077 within 0


Gene organization within MGE regions


Location: 40375..85077
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  Q7640_RS00165 (Q7640_00165) - 40375..42054 (+) 1680 WP_172412329.1 recombinase family protein -
  Q7640_RS00170 (Q7640_00170) - 42143..42481 (+) 339 WP_031796882.1 SAUGI family uracil-DNA glycosylase inhibitor -
  Q7640_RS00175 (Q7640_00175) - 42575..42886 (+) 312 WP_168754273.1 DUF960 family protein -
  Q7640_RS00180 (Q7640_00180) - 42904..43407 (+) 504 WP_341973686.1 DUF1643 domain-containing protein -
  Q7640_RS00185 (Q7640_00185) - 43421..43642 (+) 222 WP_168754275.1 hypothetical protein -
  Q7640_RS00190 (Q7640_00190) - 43721..45988 (-) 2268 WP_168754276.1 CDP-glycerol:glycerophosphate glycerophosphotransferase -
  Q7640_RS00195 (Q7640_00195) - 46245..46427 (+) 183 WP_031864945.1 hypothetical protein -
  Q7640_RS00200 (Q7640_00200) - 47469..47769 (-) 301 Protein_37 type I restriction-modification system subunit M N-terminal domain-containing protein -
  Q7640_RS00205 (Q7640_00205) - 47951..48820 (+) 870 WP_168754285.1 hypothetical protein -
  Q7640_RS00210 (Q7640_00210) - 49469..49702 (-) 234 WP_000400093.1 hypothetical protein -
  Q7640_RS00215 (Q7640_00215) pls 49948..54798 (+) 4851 WP_341973687.1 plasmin-sensitive LPXTG-anchored glycoprotein Pls -
  Q7640_RS00220 (Q7640_00220) - 54922..56538 (+) 1617 WP_000393941.1 hypothetical protein -
  Q7640_RS00225 (Q7640_00225) - 56698..58209 (-) 1512 WP_000640645.1 glycosyltransferase -
  Q7640_RS00230 (Q7640_00230) - 58232..59890 (-) 1659 WP_001621813.1 Mur ligase family protein -
  Q7640_RS00235 (Q7640_00235) - 59884..60282 (-) 399 WP_001621810.1 hypothetical protein -
  Q7640_RS00240 (Q7640_00240) - 60479..61153 (-) 675 WP_001106057.1 IS6-like element IS257 family transposase -
  Q7640_RS00245 (Q7640_00245) - 61237..61578 (+) 342 WP_001797647.1 hydroxymethylglutaryl-CoA synthase -
  Q7640_RS00250 (Q7640_00250) - 62655..63398 (+) 744 WP_000958858.1 glycerophosphoryl diester phosphodiesterase -
  Q7640_RS00255 (Q7640_00255) - 63495..63923 (+) 429 WP_000872606.1 MaoC family dehydratase -
  Q7640_RS00260 (Q7640_00260) mecA 63969..65978 (-) 2010 WP_078056052.1 PBP2a family beta-lactam-resistant peptidoglycan transpeptidase MecA -
  Q7640_RS00265 (Q7640_00265) mecR1 66075..67832 (+) 1758 WP_000952923.1 beta-lactam sensor/signal transducer MecR1 -
  Q7640_RS00270 (Q7640_00270) mecI 67832..68203 (+) 372 Protein_51 mecA-type methicillin resistance repressor MecI -
  Q7640_RS00275 (Q7640_00275) psm-mec 68288..68356 (-) 69 WP_014532405.1 phenol-soluble modulin PSM-mec -
  Q7640_RS00280 (Q7640_00280) - 68676..69824 (+) 1149 WP_000427807.1 ROK family transcriptional regulator -
  Q7640_RS00285 (Q7640_00285) cstB 69938..71272 (-) 1335 Protein_54 persulfide dioxygenase-sulfurtransferase CstB -
  Q7640_RS00290 (Q7640_00290) - 71304..72368 (-) 1065 WP_341973688.1 DsrE/DsrF/DrsH-like family protein -
  Q7640_RS00295 (Q7640_00295) cstR 72504..72764 (+) 261 WP_000220507.1 persulfide-sensing transcriptional repressor CstR -
  Q7640_RS00300 (Q7640_00300) - 72764..73402 (+) 639 Protein_57 sulfite exporter TauE/SafE family protein -
  Q7640_RS00305 (Q7640_00305) - 73676..74293 (-) 618 WP_000562107.1 CadD family cadmium resistance transporter -
  Q7640_RS00310 (Q7640_00310) - 74374..76788 (-) 2415 WP_000378485.1 cadmium-translocating P-type ATPase CadA -
  Q7640_RS00315 (Q7640_00315) - 76781..77146 (-) 366 WP_000159127.1 metalloregulator ArsR/SmtB family transcription factor -
  Q7640_RS00320 (Q7640_00320) - 77332..77709 (-) 378 WP_001041908.1 DUF6262 family protein -
  Q7640_RS00325 (Q7640_00325) - 77716..79608 (-) 1893 WP_014532403.1 site-specific integrase -
  Q7640_RS00330 (Q7640_00330) - 79803..80126 (-) 324 WP_000088091.1 JAB domain-containing protein -
  Q7640_RS00335 (Q7640_00335) - 80119..80324 (-) 206 Protein_64 hypothetical protein -
  Q7640_RS00340 (Q7640_00340) - 80326..80847 (-) 522 WP_000836008.1 DUF1643 domain-containing protein -
  Q7640_RS00345 (Q7640_00345) - 80866..81177 (-) 312 WP_000833212.1 DUF960 family protein -
  Q7640_RS00350 (Q7640_00350) - 81262..81612 (-) 351 WP_000171449.1 SAUGI family uracil-DNA glycosylase inhibitor -
  Q7640_RS00355 (Q7640_00355) ccrB 82082..83710 (-) 1629 WP_001186596.1 recombinase family protein Machinery gene
  Q7640_RS00360 (Q7640_00360) ccrA 83731..85077 (-) 1347 WP_000816499.1 recombinase family protein Machinery gene

Sequence

Protein


Download         Length: 448 a.a.        Molecular weight: 52138.19 Da        Isoelectric Point: 10.1760

>NTDB_id=863373 Q7640_RS00360 WP_000816499.1 83731..85077(-) (ccrA) [Staphylococcus aureus strain 2010N21-057]
MKRAIGYLRQSTTKQQSLPAQKQAIELLAPKHNIQNIQYISDKQSGRTDNRTGYQQVTERIQQRQCDVLCCYRLNRLHRN
LKNALKLMKLCQKYHVHILSVHDGYFDMDKAFDRLKLNIFMSLAELESDNIGEQVKNGLREKAKQGKLITTHAPFGYHYQ
NGTFIINNDESPTVKAVFNYYLQGYGYKKIAQYLEDDNKLITRKPYQVRNIIMNPNYCGRVINQYGQYNNMVPPIVSATK
YEHAQAIRNKKQLHCIPSENQLKQKIKCPCCDSTLTNMTIRKKHTLRYYICPKNMNESRFVCSFKGINAQKLEVQVLATC
QNFFQNQQLYSKINNAIHQRLKKQRVIEAKSTLTQEQLIDKLAKGMIDAESFRKQTHLMNQKHKTISSISDNQLQTSLQK
VIQKSFTLNMLHPYIDEIRITKNKALVGIYFKNEPLNIVNQTSQSSIA

Nucleotide


Download         Length: 1347 bp        

>NTDB_id=863373 Q7640_RS00360 WP_000816499.1 83731..85077(-) (ccrA) [Staphylococcus aureus strain 2010N21-057]
ATGAAACGAGCCATTGGTTATTTGCGCCAAAGTACAACGAAACAACAATCACTCCCAGCTCAAAAGCAAGCAATAGAATT
ATTAGCTCCAAAGCACAATATTCAAAATATCCAATACATTAGTGATAAGCAATCAGGCAGAACAGATAATCGAACAGGCT
ATCAACAAGTCACCGAACGCATCCAACAAAGACAATGTGACGTATTATGTTGTTATCGCTTGAATCGACTTCATCGCAAC
TTGAAAAATGCATTAAAACTCATGAAACTCTGTCAAAAATATCATGTTCATATTCTAAGTGTTCATGATGGCTATTTTGA
TATGGATAAAGCGTTTGATCGCCTAAAACTCAATATATTCATGAGTCTGGCTGAACTTGAATCCGATAATATTGGAGAAC
AAGTCAAAAATGGACTTAGAGAAAAGGCAAAACAAGGTAAACTCATAACGACCCATGCGCCTTTCGGTTATCACTATCAA
AATGGTACTTTCATCATTAATAATGATGAATCACCTACCGTCAAAGCTGTATTCAATTATTATCTTCAAGGATATGGCTA
CAAGAAGATTGCACAATATTTAGAAGACGATAATAAACTTATTACCCGCAAGCCTTATCAGGTACGAAATATAATTATGA
ACCCAAATTATTGTGGTCGTGTCATCAATCAATATGGTCAATATAACAATATGGTACCACCTATTGTTTCGGCAACGAAA
TATGAACATGCTCAAGCAATCCGTAATAAGAAGCAACTTCACTGTATACCTTCAGAGAATCAGCTGAAACAAAAGATCAA
ATGTCCTTGTTGTGACTCAACACTGACAAATATGACAATAAGAAAAAAACATACATTGCGATATTATATTTGTCCTAAAA
ATATGAATGAATCTCGCTTTGTCTGTTCATTCAAAGGAATAAATGCACAAAAATTAGAAGTTCAAGTCTTAGCTACATGT
CAGAACTTCTTTCAAAACCAACAGCTCTATTCAAAAATTAATAATGCAATTCATCAACGCCTCAAAAAACAAAGAGTGAT
AGAAGCTAAAAGTACGCTAACTCAAGAACAACTGATAGATAAACTTGCCAAAGGTATGATTGATGCTGAATCATTCAGAA
AACAGACTCATTTGATGAATCAAAAGCACAAAACCATATCCTCCATAAGTGATAATCAGTTACAAACATCACTACAAAAG
GTTATACAGAAAAGTTTCACGTTAAACATGCTGCATCCCTATATTGATGAAATTCGCATTACAAAAAATAAAGCCCTTGT
TGGGATCTATTTCAAAAATGAACCATTGAACATTGTGAACCAAACCTCGCAATCATCGATTGCTTAA

Domains

Predicted by InterproScan.

Recombinase (Recombinase)

(168-250)

Recombinase zinc beta ribbon domain (Zn_ribbon_recom)

(262-321)

Resolvase, N terminal domain (Resolvase)

(4-147)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9R3W9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ccrA Staphylococcus aureus COL

78.174

100

0.783
  ccrA Staphylococcus aureus N315

72.383

100

0.725