Detailed information NTG0860195

Bioinformatically predicted

Overview

• Name: vraS
• Type: Regulator
• Locus tag: Q3V86_RS10040
• Genome accession: NZ_CP130547
• Coordinates: 1997531..1998574 (-)
• Length: 347 a.a.
• NCBI ID: WP_001017131.1
• Uniprot ID: A0A0D1IMN4
• Organism: Staphylococcus aureus strain SA04-SX
• Function: repress expression of competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 1992531..2003574

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
Q3V86_RS10010	-	1992952..1994208 (-)	1257	WP_001793428.1	aminopeptidase	-
Q3V86_RS10015	-	1994211..1994411 (-)	201	WP_000180460.1	DUF1128 family protein	-
Q3V86_RS10020	-	1994558..1995022 (+)	465	WP_000228666.1	low molecular weight protein-tyrosine-phosphatase	-
Q3V86_RS10025	-	1995029..1995304 (+)	276	WP_000428172.1	YtxH domain-containing protein	-
Q3V86_RS10030	-	1995582..1996799 (+)	1218	WP_000037081.1	YihY/virulence factor BrkB family protein	-
Q3V86_RS10035	vraR	1996912..1997541 (-)	630	WP_000153535.1	two-component system response regulator VraR	Regulator
Q3V86_RS10040	vraS	1997531..1998574 (-)	1044	WP_001017131.1	sensor histidine kinase	Regulator
Q3V86_RS10045	liaF	1998571..1999272 (-)	702	WP_000149064.1	cell wall-active antibiotics response protein LiaF	-
Q3V86_RS10050	-	1999287..1999673 (-)	387	WP_001110182.1	hypothetical protein	-
Q3V86_RS10055	map	1999890..2000648 (-)	759	WP_000636145.1	type I methionyl aminopeptidase	-
Q3V86_RS10060	-	2001122..2002108 (+)	987	WP_000999712.1	aromatic acid exporter family protein	-
Q3V86_RS10065	-	2002297..2002710 (-)	414	WP_025174370.1	hypothetical protein	-
Q3V86_RS10070	-	2002739..2002849 (-)	111	WP_014937049.1	hypothetical protein	-

Sequence

Protein

• Length: 347 a.a.
• Molecular weight: 40044.52 Da
• Isoelectric Point: 6.0577

>NTDB_id=860195 Q3V86_RS10040 WP_001017131.1 1997531..1998574(-) (vraS) [Staphylococcus aureus strain SA04-SX]
MNHYIRTIGSMLILVYSMLAAFLFIDKVFVNIIYFQGMFYTQIFGIPVFLFLNLIIILLCIIVGSVLAYKINQQNDWIKT
QIERSMEGETVGINDQNIEIYSETLDLYHTLVPLNQELHKLRLKTQNLTNENYNINDVKVKKIIEDERQRLARELHDSVS
QQLFAASMMLSAIKETKLEPPLDQQIPILEKMVQDSQLEMRALLLHLRPLGLKDKSLGEGIKDLVIDLQKKVPMKVVHEI
QDFKVPKGIEDHLFRITQEAISNTLRHSNGTKVTVELFNKDDYLLLRIQDNGKGFNVDEKLEQSYGLKNMRERALEIGAT
FHIVSLPDSGTRIEVKAPLNKEDSYDD

Nucleotide

• Length: 1044 bp

>NTDB_id=860195 Q3V86_RS10040 WP_001017131.1 1997531..1998574(-) (vraS) [Staphylococcus aureus strain SA04-SX]
ATGAACCACTACATTAGAACAATTGGTTCAATGCTCATCTTAGTATATAGCATGCTAGCTGCATTTCTGTTCATCGATAA
AGTTTTTGTAAATATCATCTATTTTCAAGGTATGTTTTATACACAAATATTCGGAATACCAGTCTTTTTATTTTTAAATC
TCATCATCATATTATTGTGTATTATTGTTGGTTCGGTTCTCGCTTACAAAATCAATCAGCAAAATGATTGGATTAAGACG
CAAATTGAGCGTTCAATGGAAGGCGAAACAGTTGGCATTAATGATCAAAATATAGAAATATATAGTGAAACGTTAGATTT
ATACCATACACTCGTACCTTTAAATCAAGAATTGCATAAATTGCGACTTAAAACTCAAAACTTAACCAATGAAAATTATA
ATATTAATGATGTGAAAGTTAAAAAGATTATTGAAGATGAACGTCAAAGACTAGCACGAGAACTTCACGATTCTGTTAGT
CAGCAACTTTTTGCGGCAAGTATGATGCTATCTGCTATCAAAGAAACGAAATTAGAACCACCATTAGACCAACAAATTCC
GATTTTAGAGAAAATGGTTCAAGATTCGCAGCTAGAAATGCGTGCTTTGCTGTTACATTTAAGACCGCTTGGTTTAAAAG
ACAAATCTTTAGGTGAGGGTATTAAAGATTTAGTTATTGATTTACAAAAAAAAGTGCCAATGAAAGTTGTGCATGAAATA
CAAGATTTTAAAGTGCCTAAAGGTATTGAAGATCATTTGTTCAGAATTACACAGGAAGCAATTTCGAATACATTGCGTCA
TTCAAACGGTACAAAAGTGACAGTAGAATTGTTTAATAAAGACGATTATTTATTGTTGAGAATTCAAGACAATGGTAAAG
GTTTTAATGTTGATGAAAAATTAGAACAAAGTTATGGACTTAAAAATATGCGTGAAAGAGCTTTGGAAATTGGTGCAACG
TTCCATATTGTATCATTGCCAGATTCAGGTACACGTATCGAGGTGAAAGCACCTTTAAATAAGGAGGATTCGTATGACGA
TTAA

Domains

Predicted by InterproScan.

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (249-340)

• Histidine kinase (HisKA_3) (147-210)

3D structure

• AlphaFold DB: A0A0D1IMN4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
vraS	Staphylococcus aureus N315	100	100	1